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Participants with locally advanced or metastatic solid tumors with no standard therapeutic alternative in the United States were included in this cohort.","id":"EG000","otherNumAffected":5,"otherNumAtRisk":12,"seriousNumAffected":7,"seriousNumAtRisk":12,"title":"Western Safety Cohort"},{"deathsNumAffected":13,"deathsNumAtRisk":15,"description":"TAK-931 50 mg (2x25 mg or 5x10 mg), capsules, orally, QD for 14 days, followed by a 7-day washout period (14 days on and 7 days off study drug), in 21-day cycles until disease progression or unacceptable treatment-related toxicity up to 4 cycles. Participants with metastatic pancreatic cancer who had progressed after at least 1 line of standard chemotherapy were included in this cohort.","id":"EG001","otherNumAffected":8,"otherNumAtRisk":15,"seriousNumAffected":6,"seriousNumAtRisk":15,"title":"Pancreatic Cancer Cohort"},{"deathsNumAffected":17,"deathsNumAtRisk":35,"description":"TAK-931 50 mg (2x25 mg or 5x10 mg), capsules, orally, QD for 14 days, followed by a 7-day washout period (14 days on and 7 days off study drug), in 21-day cycles until disease progression or unacceptable treatment-related toxicity up to 12 cycles. Participants with metastatic CRC who had progressed after at least 2 lines of previous standard chemotherapy were included in this cohort.","id":"EG002","otherNumAffected":27,"otherNumAtRisk":35,"seriousNumAffected":8,"seriousNumAtRisk":35,"title":"Metastatic CRC Cohort"},{"deathsNumAffected":12,"deathsNumAtRisk":21,"description":"TAK-931 50 mg (2x25 mg or 5x10 mg), capsules, orally, QD for 14 days, followed by a 7-day washout period (14 days on and 7 days off study drug), in 21-day cycles until disease progression or unacceptable treatment-related toxicity up to 8 cycles. Participants with metastatic sqEC who had progressed after at least 1 line of standard chemotherapy were included in this cohort.","id":"EG003","otherNumAffected":14,"otherNumAtRisk":21,"seriousNumAffected":5,"seriousNumAtRisk":21,"title":"sqEC Cohort"},{"deathsNumAffected":8,"deathsNumAtRisk":18,"description":"TAK-931 50 mg (2x25 mg or 5x10 mg), capsules, orally, QD for 14 days, followed by a 7-day washout period (14 days on and 7 days off study drug), in 21-day cycles until disease progression or unacceptable treatment-related toxicity up to 18 cycles. Participants with metastatic sqNSCLC who had progressed after at least 2 lines of standard treatment were included in this cohort.","id":"EG004","otherNumAffected":14,"otherNumAtRisk":18,"seriousNumAffected":3,"seriousNumAtRisk":18,"title":"sqNSCLC Cohort"}],"frequencyThreshold":"5","otherEvents":[{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA 23.0","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":12},{"groupId":"EG001","numAffected":5,"numAtRisk":15},{"groupId":"EG002","numAffected":16,"numAtRisk":35},{"groupId":"EG003","numAffected":7,"numAtRisk":21},{"groupId":"EG004","numAffected":7,"numAtRisk":18}],"term":"Nausea"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA 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