{"denomUnitsSelected":"Participants","description":"Relevant individual PK parameters will be estimated using non-compartmental or compartmental PK methods with the software WinNonlin. The PK variables will be tabulated and descriptive statistics (e.g., geometric means and coefficients of variation) and compared across dose levels (if applicable) using nonparametric statistical testing techniques. PK parameters (i.e., steady state concentration \\[Css\\], clearance \\[Cl\\], and area under the curve \\[AUC\\]) will be correlated with pharmacodynamics effects using nonparametric statistical testing techniques.","reportingStatus":"NOT_POSTED","timeFrame":"Up to 5 years","title":"Pharmacokinetics (PK) Parameters Assessment for Ibrutinib, Doxorubicin Hydrochloride, Etoposide, and Vincristine Sulfate","type":"SECONDARY"}