{"analyses":[{"groupDescription":"Week 5","groupIds":["OG000","OG002"],"nonInferiorityType":"SUPERIORITY","pValue":"0.78","pValueComment":"One-sided significance level 0.05","statisticalMethod":"t-test, 1 sided"},{"groupDescription":"Week 5","groupIds":["OG001","OG002"],"nonInferiorityType":"SUPERIORITY","pValue":"0.51","pValueComment":"One-sided significance level 0.05","statisticalMethod":"t-test, 1 sided"},{"groupDescription":"Week 9","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY","pValue":"0.49","pValueComment":"One-sided significance level 0.05","statisticalMethod":"t-test, 1 sided"},{"groupDescription":"Week 9","groupIds":["OG001","OG002"],"nonInferiorityType":"SUPERIORITY","pValue":"0.50","pValueComment":"One-sided significance level 0.05","statisticalMethod":"t-test, 1 sided"}],"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"1.77","value":"-0.44"},{"groupId":"OG001","spread":"1.91","value":"-0.17"},{"groupId":"OG002","spread":"2.29","value":"-0.16"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"66"},{"groupId":"OG001","value":"60"},{"groupId":"OG002","value":"62"}],"units":"Participants"}],"title":"Week 5"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"1.68","value":"-0.42"},{"groupId":"OG001","spread":"1.86","value":"-0.43"},{"groupId":"OG002","spread":"2.39","value":"-0.43"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"65"},{"groupId":"OG001","value":"61"},{"groupId":"OG002","value":"63"}],"units":"Participants"}],"title":"Week 9"}],"denoms":[{"counts":[{"groupId":"OG000","value":"79"},{"groupId":"OG001","value":"74"},{"groupId":"OG002","value":"77"}],"units":"Participants"}],"description":"The PHQ-4 is a brief screening questionnaire for depression. Possible scores range from 0 to 12, with higher scores indicating more severe depression. Change score is calculated by subtracting baseline from later score, with a negative change score indicating decreased severity of depression. This measure is referred to as \"depressive mood\" in the protocol.","dispersionType":"Standard Error","groups":[{"description":"One Bupropion 150 mg XL capsule PO in a.m. daily for one week; one Bupropion 150 mg XL capsule and one placebo capsule PO in a.m. daily for 8 weeks; one placebo capsule daily PO in a.m. for one 1 week (titration off).","id":"OG000","title":"Bupropion 150 mg"},{"description":"One Bupropion 150 mg XL capsule PO in a.m. daily for one week; two Bupropion 150 mg XL capsules PO in a.m. daily for 8 weeks (300 mg target dose); one Bupropion 150 mg XL capsule PO in a.m. daily for 1 week (titration off)","id":"OG001","title":"Bupropion 300 mg"},{"description":"One placebo capsule PO in a.m. daily for 1 week; two placebo capsules PO in a.m. daily for 8 weeks; one placebo capsule PO in a.m. daily for 1 week (titration off)","id":"OG002","title":"Placebo"}],"paramType":"MEAN","populationDescription":"Eligible with baseline data","reportingStatus":"POSTED","timeFrame":"Baseline (prior to randomization) and 5 and 9 weeks from start of treatment (within 21 days of randomization)","title":"Change From Baseline in the Patient Health Questionnaire (PHQ)-4 Score (\"Depressive Mood\")","type":"SECONDARY","unitOfMeasure":"units on a scale"}