{"description":"All-cause mortality was assessed in eligible participants. Adverse events were assessed in eligible participants with adverse event data who started protocol treatment.","eventGroups":[{"deathsNumAffected":0,"deathsNumAtRisk":79,"description":"One Bupropion 150 mg XL capsule PO in a.m. daily for one week; one Bupropion 150 mg XL capsule and one placebo capsule PO in a.m. daily for 8 weeks; one placebo capsule daily PO in a.m. for one 1 week (titration off).","id":"EG000","otherNumAffected":53,"otherNumAtRisk":77,"seriousNumAffected":1,"seriousNumAtRisk":77,"title":"Bupropion 150 mg"},{"deathsNumAffected":0,"deathsNumAtRisk":74,"description":"One Bupropion 150 mg XL capsule PO in a.m. daily for one week; two Bupropion 150 mg XL capsules PO in a.m. daily for 8 weeks (300 mg target dose); one Bupropion 150 mg XL capsule PO in a.m. daily for 1 week (titration off)","id":"EG001","otherNumAffected":55,"otherNumAtRisk":73,"seriousNumAffected":0,"seriousNumAtRisk":73,"title":"Bupropion 300 mg"},{"deathsNumAffected":0,"deathsNumAtRisk":77,"description":"One placebo capsule PO in a.m. daily for 1 week; two placebo capsules PO in a.m. daily for 8 weeks; one placebo capsule PO in a.m. daily for 1 week (titration off)","id":"EG002","otherNumAffected":57,"otherNumAtRisk":76,"seriousNumAffected":0,"seriousNumAtRisk":76,"title":"Placebo"}],"frequencyThreshold":"5","otherEvents":[{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Ear and labyrinth disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":4,"numAtRisk":77},{"groupId":"EG001","numAffected":0,"numAtRisk":73},{"groupId":"EG002","numAffected":2,"numAtRisk":76}],"term":"Tinnitus"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":23,"numAtRisk":77},{"groupId":"EG001","numAffected":24,"numAtRisk":73},{"groupId":"EG002","numAffected":20,"numAtRisk":76}],"term":"Constipation"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":4,"numAtRisk":77},{"groupId":"EG001","numAffected":3,"numAtRisk":73},{"groupId":"EG002","numAffected":8,"numAtRisk":76}],"term":"Diarrhea"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":21,"numAtRisk":77},{"groupId":"EG001","numAffected":30,"numAtRisk":73},{"groupId":"EG002","numAffected":25,"numAtRisk":76}],"term":"Dry mouth"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":77},{"groupId":"EG001","numAffected":4,"numAtRisk":73},{"groupId":"EG002","numAffected":1,"numAtRisk":76}],"term":"Gastroesophageal reflux disease"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":12,"numAtRisk":77},{"groupId":"EG001","numAffected":14,"numAtRisk":73},{"groupId":"EG002","numAffected":22,"numAtRisk":76}],"term":"Nausea"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"General disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":5,"numAtRisk":77},{"groupId":"EG001","numAffected":6,"numAtRisk":73},{"groupId":"EG002","numAffected":5,"numAtRisk":76}],"term":"Fatigue"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"General disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":4,"numAtRisk":77},{"groupId":"EG001","numAffected":1,"numAtRisk":73},{"groupId":"EG002","numAffected":3,"numAtRisk":76}],"term":"Pain"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Metabolism and nutrition disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":13,"numAtRisk":77},{"groupId":"EG001","numAffected":15,"numAtRisk":73},{"groupId":"EG002","numAffected":20,"numAtRisk":76}],"term":"Anorexia"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Musculoskeletal and connective tissue disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":77},{"groupId":"EG001","numAffected":2,"numAtRisk":73},{"groupId":"EG002","numAffected":7,"numAtRisk":76}],"term":"Arthralgia"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Nervous system disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":9,"numAtRisk":77},{"groupId":"EG001","numAffected":13,"numAtRisk":73},{"groupId":"EG002","numAffected":14,"numAtRisk":76}],"term":"Dizziness"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Nervous system disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":23,"numAtRisk":77},{"groupId":"EG001","numAffected":36,"numAtRisk":73},{"groupId":"EG002","numAffected":30,"numAtRisk":76}],"term":"Headache"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Nervous system disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":4,"numAtRisk":77},{"groupId":"EG001","numAffected":4,"numAtRisk":73},{"groupId":"EG002","numAffected":6,"numAtRisk":76}],"term":"Tremor"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Psychiatric disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":4,"numAtRisk":77},{"groupId":"EG001","numAffected":5,"numAtRisk":73},{"groupId":"EG002","numAffected":3,"numAtRisk":76}],"term":"Anxiety"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Psychiatric disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":4,"numAtRisk":77},{"groupId":"EG001","numAffected":3,"numAtRisk":73},{"groupId":"EG002","numAffected":4,"numAtRisk":76}],"term":"Depression"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Psychiatric disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":24,"numAtRisk":77},{"groupId":"EG001","numAffected":27,"numAtRisk":73},{"groupId":"EG002","numAffected":29,"numAtRisk":76}],"term":"Insomnia"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Psychiatric disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":77},{"groupId":"EG001","numAffected":0,"numAtRisk":73},{"groupId":"EG002","numAffected":4,"numAtRisk":76}],"term":"Libido decreased"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Respiratory, thoracic and mediastinal disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":77},{"groupId":"EG001","numAffected":1,"numAtRisk":73},{"groupId":"EG002","numAffected":4,"numAtRisk":76}],"term":"Allergic rhinitis"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Respiratory, thoracic and mediastinal disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":11,"numAtRisk":77},{"groupId":"EG001","numAffected":9,"numAtRisk":73},{"groupId":"EG002","numAffected":14,"numAtRisk":76}],"term":"Nasal congestion"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Respiratory, thoracic and mediastinal disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":77},{"groupId":"EG001","numAffected":1,"numAtRisk":73},{"groupId":"EG002","numAffected":7,"numAtRisk":76}],"term":"Pharyngolaryngeal pain"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Respiratory, thoracic and mediastinal disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":5,"numAtRisk":77},{"groupId":"EG001","numAffected":2,"numAtRisk":73},{"groupId":"EG002","numAffected":4,"numAtRisk":76}],"term":"Sore throat"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Vascular disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":5,"numAtRisk":77},{"groupId":"EG001","numAffected":7,"numAtRisk":73},{"groupId":"EG002","numAffected":6,"numAtRisk":76}],"term":"Hot flashes"}],"seriousEvents":[{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Psychiatric disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":77},{"groupId":"EG001","numAffected":0,"numAtRisk":73},{"groupId":"EG002","numAffected":0,"numAtRisk":76}],"term":"Insomnia"}],"timeFrame":"1,2,5,7, and 9 weeks from start of study treatment (within 21 days of randomization).]"}