{"description":"Biopsy related AE reporting is collected routinely using case report forms. The SAE table reflects biopsy related CTCAEs submitted by the institution via expedited reporting (NCI AdEERs / CAeRs). All remaining biopsy related CTCAEs collected by means other than expedited reporting are non-serious and are reported in the \"AE Other\" table. Patients enrolled after Stage 1 (12/31/21) are excluded from AE reporting. All-Cause Mortality includes all deaths collected on the study for enrolled patients.","eventGroups":[{"deathsNumAffected":906,"deathsNumAtRisk":1377,"description":"Patients undergo biopsy along with tumor mutational screening of the biopsy material for specific, pre-defined mutations, amplifications, or translocations of interest via tumor sequencing and immunohistochemistry. Patients also undergo collection of blood samples for research purposes.","id":"EG000","otherNumAffected":1,"otherNumAtRisk":1343,"seriousNumAffected":2,"seriousNumAtRisk":1343,"title":"NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice) Screening Protocol"}],"frequencyThreshold":"0","otherEvents":[{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Nervous system disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":1343}],"term":"Headache"}],"seriousEvents":[{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":1343}],"term":"Infections and infestations - Other, specify"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":1343}],"term":"Meningitis"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Respiratory, thoracic and mediastinal disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":1343}],"term":"Laryngeal edema"}],"timeFrame":"The reporting timeframe includes adverse events occurring within 14 days following a biopsy performed after enrollment on this study. All-Cause Mortality monitored/assessed up to 5 years."}