{"eventGroups":[{"deathsNumAffected":9,"deathsNumAtRisk":20,"description":"Must be refractory or intolerant to at least one line of 5FU-based chemotherapy for metastatic disease and must not have clinically symptomatic malignant small bowel obstruction. Cobimetinib (60 mgorally once daily for days 1 - 21) and atezolizumab (840 mg intravenously every 2 weeks) every 28-day cycle.","id":"EG000","otherNumAffected":9,"otherNumAtRisk":20,"seriousNumAffected":0,"seriousNumAtRisk":20,"title":"Small Bowel Adenocarcinoma"}],"frequencyThreshold":"0","otherEvents":[{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":8,"numAtRisk":20}],"term":"Anemia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Ear and labyrinth disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":20}],"term":"Tinnitus"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Endocrine disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":20}],"term":"Hypothyroidism"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Eye disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":20}],"term":"Retinopathy"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":4,"numAtRisk":20}],"term":"Abdominal Pain"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":20}],"term":"Bloating"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":4,"numAtRisk":20}],"term":"Constipation"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":6,"numAtRisk":20}],"term":"Diarrhea"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":20}],"term":"Dry Mouth"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":20}],"term":"Gatroesophageal Disease"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":20}],"term":"Gastrointestinal Disease-Others (Sore Gums)"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":20}],"term":"Hemorrhoids"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":20}],"term":"Mucositis"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":5,"numAtRisk":20}],"term":"Nausea"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":4,"numAtRisk":20}],"term":"Vomiting"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"General disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":20}],"term":"Limb Edema"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"General disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":9,"numAtRisk":20}],"term":"Fatigue"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"General disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":20}],"term":"Fever"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"General disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":20}],"term":"Gait Disturbances"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":20}],"term":"UTI"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":20}],"term":"Infections and Infestations-Other (Influenza A and H1 2009"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Injury, poisoning and procedural complications","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":20}],"term":"Bruising"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":4,"numAtRisk":20}],"term":"Alanin aminotransferace increase"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":5,"numAtRisk":20}],"term":"Alkaline Phosphatase increase"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":5,"numAtRisk":20}],"term":"Aspartate aminotransferase Increase"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":20}],"term":"Total Bilirubin Increase"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":20}],"term":"Cholesterol High"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":6,"numAtRisk":20}],"term":"CPK Increased"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":20}],"term":"INR increased"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":20}],"term":"Platelet Count decrease"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":20}],"term":"White Blood Cell Count Increaese"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Metabolism and nutrition disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":20}],"term":"Hypomagnesemia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Metabolism and nutrition disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":20}],"term":"Anorexia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Metabolism and nutrition disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":20}],"term":"Hypernatremia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Metabolism and nutrition disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":20}],"term":"Hypokalemia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Metabolism and nutrition disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":20}],"term":"Hyperglycemia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Musculoskeletal and connective tissue disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":20}],"term":"Back Pain"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Musculoskeletal and connective tissue disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":20}],"term":"Myalgia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Musculoskeletal and connective tissue disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":20}],"term":"Flank Pain"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Musculoskeletal and connective tissue disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":20}],"term":"Generalized Muscle Weakness"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Nervous system disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":20}],"term":"Peripheral Neuropathy"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Nervous system disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":20}],"term":"Dizziness"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Nervous system disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":20}],"term":"Nervous System Disorders-others (Brain Metastasis)"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Psychiatric disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":5,"numAtRisk":20}],"term":"Insomnia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Psychiatric disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":20}],"term":"Anxiety"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Psychiatric disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":20}],"term":"Confusion"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Renal and urinary disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":20}],"term":"Hematuria"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Renal and urinary disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":20}],"term":"Urinary Frequency"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Renal and urinary disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":20}],"term":"Urinary Incontinence"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Reproductive system and breast disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":20}],"term":"Pelvic Pain"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Respiratory, thoracic and mediastinal disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":20}],"term":"Dyspnea"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Respiratory, thoracic and mediastinal disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":20}],"term":"Cough"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Respiratory, thoracic and mediastinal disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":20}],"term":"Pleuritic Pain"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Skin and subcutaneous tissue disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":20}],"term":"Nail Discoloration"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Skin and subcutaneous tissue disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":20}],"term":"Palmar-planter Erythrodysesthesia Syndrome"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Skin and subcutaneous tissue disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":20}],"term":"Periorbital Edema"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Skin and subcutaneous tissue disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":20}],"term":"Pruritus"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Skin and subcutaneous tissue disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":20}],"term":"Rash Acneiform"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Skin and subcutaneous tissue disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":20}],"term":"Rash Maculo-Papular"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Vascular disorders","sourceVocabulary":"CTCAE v4","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":20}],"term":"Hypertension"}],"timeFrame":"3 years"}