{"eventGroups":[{"deathsNumAffected":6,"deathsNumAtRisk":14,"description":"Reduced-intensity conditioning and transplantation of human leukocyte antigen (HLA) -haploidentical related donor stem cells for patients \\<55 years old with hematopoietic cell transplantation Comorbidity Index (HCT-CI) ≤2\n\nHaplo HCT \\<55 years old: - Fludarabine (Flu)\n\n* Cyclophosphamide (Cy)\n* Melphalan (Mel)\n* Total body irradiation (TBI)\n* Non-T-cell depleted donor bone marrow stem cell infusion Day 0\n\nGVHD Prophylaxis: - Cyclophosphamide (Cy)\n\n* Tacrolimus (Tac)\n* Mycophenolate mofetil (MMF)","id":"EG000","otherNumAffected":10,"otherNumAtRisk":14,"seriousNumAffected":6,"seriousNumAtRisk":14,"title":"Arm A: Haplo-HCT <55 Years Old"},{"deathsNumAffected":13,"deathsNumAtRisk":21,"description":"Reduced-intensity conditioning and transplantation of human leukocyte antigen (HLA) -haploidentical related donor stem cells for patients ≥55 years old or younger with hematopoietic cell transplantation Comorbidity Index (HCT-CI) ≥3.\n\nHaplo HCT ≥55 years old: - Fludarabine (Flu)\n\n* Cyclophosphamide (Cy)\n* Melphalan (Mel): Dose reduction by 30%\n* Total body irradiation (TBI)\n* Non-T-cell depleted donor bone marrow stem cell infusion\n\nGVHD Prophylaxis: - Cyclophosphamide (Cy)\n\n* Tacrolimus (Tac)\n* Mycophenolate mofetil (MMF)","id":"EG001","otherNumAffected":11,"otherNumAtRisk":21,"seriousNumAffected":9,"seriousNumAtRisk":21,"title":"CLOSED Arm B: Haplo-HCT ≥55 Years Old"},{"deathsNumAffected":5,"deathsNumAtRisk":8,"description":"Reduced-intensity conditioning and transplantation of human leukocyte antigen (HLA) -haploidentical related donor stem cells for patients with hematopoietic cell transplantation Comorbidity Index (HCT-CI) ≤2 aged ≥55 and \\< 65 years old.\n\nGVHD Prophylaxis: - Cyclophosphamide (Cy)\n\n* Tacrolimus (Tac)\n* Mycophenolate mofetil (MMF)\n\nHaplo HCT ≥55 and \\< 65 years old: - Fludarabine (Flu)\n\n* Cyclophosphamide (Cy)\n* Melphalan (Mel)\n* Total body irradiation (TBI)\n* non-T-cell depleted donor bone marrow stem cells","id":"EG002","otherNumAffected":6,"otherNumAtRisk":8,"seriousNumAffected":4,"seriousNumAtRisk":8,"title":"Arm C: Haplo-HCT HCT-CI ≤2 Aged ≥55 and < 65yo"},{"deathsNumAffected":18,"deathsNumAtRisk":35,"description":"Reduced-intensity conditioning and transplantation of human leukocyte antigen (HLA) -haploidentical related donor stem cells for patients patients ≥65 and ≤75 years old OR any age group with hematopoietic cell transplantation Comorbidity Index (HCT-CI) ≥3.\n\nGVHD Prophylaxis: - Cyclophosphamide (Cy)\n\n* Tacrolimus (Tac)\n* Mycophenolate mofetil (MMF)\n\nHaplo HCT ≥65 and ≤75 years old: - Fludarabine (Flu)\n\n* Cyclophosphamide (Cy)\n* Total body irradiation (TBI)","id":"EG003","otherNumAffected":15,"otherNumAtRisk":35,"seriousNumAffected":11,"seriousNumAtRisk":35,"title":"Arm D: Haplo-HCT Aged ≥65 and ≤75yo OR Any Age HCT-CI ≥3"}],"frequencyThreshold":"0","otherEvents":[{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"Fungal Infection","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":14,"numEvents":17},{"groupId":"EG001","numAffected":2,"numAtRisk":21,"numEvents":51},{"groupId":"EG002","numAffected":3,"numAtRisk":8,"numEvents":22},{"groupId":"EG003","numAffected":4,"numAtRisk":35,"numEvents":27}],"term":"Fungal Infection"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"Viral Infection","stats":[{"groupId":"EG000","numAffected":9,"numAtRisk":14,"numEvents":95},{"groupId":"EG001","numAffected":10,"numAtRisk":21,"numEvents":152},{"groupId":"EG002","numAffected":6,"numAtRisk":8,"numEvents":43},{"groupId":"EG003","numAffected":12,"numAtRisk":35,"numEvents":67}],"term":"Viral Infection"}],"seriousEvents":[{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","stats":[{"groupId":"EG000","numAffected":6,"numAtRisk":14,"numEvents":56},{"groupId":"EG001","numAffected":9,"numAtRisk":21,"numEvents":133},{"groupId":"EG002","numAffected":4,"numAtRisk":8,"numEvents":36},{"groupId":"EG003","numAffected":11,"numAtRisk":35,"numEvents":109}],"term":"Serious bacterial Infection"}],"timeFrame":"2 years"}