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Vaccine will be given every 3 weeks for the first 24 weeks, then if there is stable or improved disease, will be given every 6 weeks for a total treatment period of 96 weeks.","id":"EG000","otherNumAffected":19,"otherNumAtRisk":19,"seriousNumAffected":6,"seriousNumAtRisk":19,"title":"Stratum A: Newly Diagnosed DIPG"},{"deathsNumAffected":7,"deathsNumAtRisk":10,"description":"Newly diagnosed children with gliomas other than DIPG who are positive for HLA-A2 and the H3.3K27M mutation that underwent radiation therapy will receive the specific H3.3K27M peptide vaccine, combined with the tetanus toxoid peptide, emulsified in Montanide. Poly-ICLC, which is a synthetic nucleic acid, will be given concurrently to improve the therapeutic effects of the vaccine. Vaccine will be given every 3 weeks for the first 24 weeks, then if there is stable or improved disease, will be given every 6 weeks for a total treatment period of 96 weeks.","id":"EG001","otherNumAffected":10,"otherNumAtRisk":10,"seriousNumAffected":8,"seriousNumAtRisk":10,"title":"Stratum B: Newly Diagnosed Glioma (Non-DIPG)"},{"deathsNumAffected":20,"deathsNumAtRisk":21,"description":"Newly diagnosed children with DIPG or other midline gliomas (excluding primary spinal cord tumors) who are positive for HLA-A2 (02:01) and the H3.3K27M mutation that underwent radiation therapy will receive the specific H3.3K27M peptide vaccine, combined with the tetanus toxoid peptide, emulsified in Montanide. Poly-ICLC, which is a synthetic nucleic acid, will be given concurrently to improve the therapeutic effects of the vaccine. Nivolumab will also be given via IV. Vaccine will be given every 3 weeks for the first 24 weeks, then if there is stable or improved disease, will be given every 6 weeks for a total treatment period of 96 weeks. Nivolumab will continue to be given every 3 weeks throughout all of treatment.","id":"EG002","otherNumAffected":21,"otherNumAtRisk":21,"seriousNumAffected":13,"seriousNumAtRisk":21,"title":"Stratum C: Newly Diagnosed DIPG or Other Midline Glioma"}],"frequencyThreshold":"0","otherEvents":[{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"CTCAE (5.0)","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":19,"numEvents":3},{"groupId":"EG001","numAffected":2,"numAtRisk":10,"numEvents":10},{"groupId":"EG002","numAffected":4,"numAtRisk":21,"numEvents":7}],"term":"Anemia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"CTCAE 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