{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"966.2604","value":"1539.565"},{"groupId":"OG001","spread":"856.2478","value":"1605.002"},{"groupId":"OG002","spread":"1428.5691","value":"1639.357"},{"groupId":"OG003","spread":"1138.2119","value":"1286.998"},{"groupId":"OG004","spread":"748.3045","value":"1189.845"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"101"},{"groupId":"OG001","value":"48"},{"groupId":"OG002","value":"14"},{"groupId":"OG003","value":"5"},{"groupId":"OG004","value":"13"}],"units":"Participants"}],"title":"Day 29"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"1057.8049","value":"1578.353"},{"groupId":"OG001","spread":"1198.3899","value":"1600.380"},{"groupId":"OG002","spread":"806.4642","value":"1405.167"},{"groupId":"OG003","spread":"2106.3362","value":"1841.667"},{"groupId":"OG004","spread":"1672.7732","value":"1792.499"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"85"},{"groupId":"OG001","value":"38"},{"groupId":"OG002","value":"12"},{"groupId":"OG003","value":"3"},{"groupId":"OG004","value":"11"}],"units":"Participants"}],"title":"Day 57"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"693.6717","value":"1308.704"},{"groupId":"OG001","spread":"802.0812","value":"1505.400"},{"groupId":"OG002","spread":"991.9922","value":"1699.700"},{"groupId":"OG003","spread":"557.9073","value":"815.500"},{"groupId":"OG004","spread":"1831.9626","value":"2255.889"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"71"},{"groupId":"OG001","value":"30"},{"groupId":"OG002","value":"10"},{"groupId":"OG003","value":"2"},{"groupId":"OG004","value":"9"}],"units":"Participants"}],"title":"Day 85"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"889.6130","value":"1533.690"},{"groupId":"OG001","spread":"1291.8497","value":"1515.300"},{"groupId":"OG002","spread":"884.1374","value":"1520.700"},{"groupId":"OG003","spread":"469.5189","value":"728.000"},{"groupId":"OG004","spread":"637.4535","value":"1433.875"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"60"},{"groupId":"OG001","value":"22"},{"groupId":"OG002","value":"10"},{"groupId":"OG003","value":"2"},{"groupId":"OG004","value":"8"}],"units":"Participants"}],"title":"Day 113"}],"denoms":[{"counts":[{"groupId":"OG000","value":"101"},{"groupId":"OG001","value":"51"},{"groupId":"OG002","value":"14"},{"groupId":"OG003","value":"5"},{"groupId":"OG004","value":"13"}],"units":"Participants"}],"description":"Trough (Cmin) concentrations of rucaparib are summarized for all patients with at least one PK sample collected. The absolute values of rucaparib plasma concentration at each time point are presented by gene.","dispersionType":"Standard Deviation","groups":[{"description":"Patients with a deleterious BRCA (breast cancer susceptibility gene) mutation detected in their tumor.","id":"OG000","title":"BRCA Mutation"},{"description":"Patients with a deleterious ATM (ataxia telangiectasia mutated serine/threonine kinase) mutation detected in their tumor.","id":"OG001","title":"ATM Mutation"},{"description":"Patients with a deleterious CDK12 (Cyclin-dependent kinase 12) mutation detected in their tumor.","id":"OG002","title":"CDK12 Mutation"},{"description":"Patients with a deleterious CHEK2 (Checkpoint Kinase 2) mutation detected in their tumor.","id":"OG003","title":"CHEK2 Mutation"},{"description":"Patients with other deleterious HRR (homologous recombination repair) gene mutation detected in their tumor.","id":"OG004","title":"Other Gene Mutation"}],"paramType":"MEDIAN","populationDescription":"Safety population with at least one PK sample collected. The safety population consists of all patients who received at least 1 dose of protocol-specified treatment.","reportingStatus":"POSTED","timeFrame":"Participants were assessed at Study Day 29, Day 57, Day 85 and Day 113","title":"Steady State Trough (Cmin) Level Rucaparib Concentrations","type":"SECONDARY","unitOfMeasure":"ng/mL"}