{"analyses":[{"ciLowerLimit":"0.620","ciNumSides":"TWO_SIDED","ciPctValue":"90","ciUpperLimit":"1.363","groupDescription":"Fed versus Fasted","groupIds":["OG000"],"nonInferiorityType":"OTHER","pValue":"0.7050","paramType":"pairwise GMR","paramValue":"0.920","statisticalComment":"1-factor ANOVA of log-transformed, dose-normalized data (factor = food effect)","statisticalMethod":"ANOVA"},{"ciLowerLimit":"0.658","ciNumSides":"TWO_SIDED","ciPctValue":"90","ciUpperLimit":"1.310","groupDescription":"Fed versus Fasted","groupIds":["OG001"],"nonInferiorityType":"OTHER","pValue":"0.7030","paramType":"pairwise GMR","paramValue":"0.929","statisticalComment":"1-factor ANOVA of log-transformed, dose-normalized data (factor = food effect)","statisticalMethod":"ANOVA"},{"ciLowerLimit":"0.725","ciNumSides":"TWO_SIDED","ciPctValue":"90","ciUpperLimit":"1.377","groupDescription":"Fed versus Fasted","groupIds":["OG002"],"nonInferiorityType":"OTHER","pValue":"0.9952","paramType":"pairwise GMR","paramValue":"0.999","statisticalComment":"1-factor ANOVA of log-transformed, dose-normalized data (factor = food effect)","statisticalMethod":"ANOVA"},{"ciLowerLimit":"0.394","ciNumSides":"TWO_SIDED","ciPctValue":"90","ciUpperLimit":"1.397","groupDescription":"Fed versus Fasted","groupIds":["OG003"],"nonInferiorityType":"OTHER","pValue":"0.4012","paramType":"pairwise GMR","paramValue":"0.742","statisticalComment":"1-factor ANOVA of log-transformed, dose-normalized data (factor = food effect)","statisticalMethod":"ANOVA"}],"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.26","value":"6030"},{"groupId":"OG001","spread":"0.37","value":"11900"},{"groupId":"OG002","spread":"0.31","value":"13100"},{"groupId":"OG003","spread":"0.29","value":"22100"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"5"},{"groupId":"OG001","value":"5"},{"groupId":"OG002","value":"7"},{"groupId":"OG003","value":"6"}],"units":"Participants"}],"title":"Fasted"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.44","value":"55550"},{"groupId":"OG001","spread":"0.27","value":"11000"},{"groupId":"OG002","spread":"0.35","value":"13100"},{"groupId":"OG003","spread":"0.89","value":"16400"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"6"},{"groupId":"OG001","value":"6"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"3"}],"units":"Participants"}],"title":"Fed"}],"denoms":[{"counts":[{"groupId":"OG000","value":"6"},{"groupId":"OG001","value":"7"},{"groupId":"OG002","value":"7"},{"groupId":"OG003","value":"6"}],"units":"Participants"}],"description":"AUC was defined as the area under the concentration-time curve of INCB001158.","dispersionType":"Geometric Coefficient of Variation","groups":[{"description":"INCB001158 was administered orally at 50 milligrams (mg) twice daily (BID) in participants with advanced/metastatic solid tumors.","id":"OG000","title":"Part 1A: INCB001158 50 mg"},{"description":"INCB001158 was administered orally at 75 mg BID in participants with advanced/metastatic solid tumors.","id":"OG001","title":"Part 1A: INCB001158 75 mg"},{"description":"INCB001158 was administered orally at 100 mg BID in participants with advanced/metastatic solid tumors.","id":"OG002","title":"Part 1A: INCB001158 100 mg"},{"description":"INCB001158 was administered orally at 150 mg BID in participants with advanced/metastatic solid tumors.","id":"OG003","title":"Part 1A: INCB001158 150 mg"}],"paramType":"GEOMETRIC_MEAN","populationDescription":"PK Population. Only participants with available date were analyzed.","reportingStatus":"POSTED","timeFrame":"Fasted: Cycle 1 Day 15: predose; 0.5, 1, 2, 4, 6, 8, and 12 hours post-dose. Fed: Cycle 2 Day 8: predose; 0.5, 1, 2, 4, 6, and 8 hours post-dose","title":"AUC of INCB001158 in the Fed and Fasted States Following Multiple Doses for Part 1A to Assess the Effect of Food","type":"SECONDARY","unitOfMeasure":"hours x ng/mL"}