{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"1640","value":"3410"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"13"}],"units":"Participants"}],"description":"Pharmacokinetics profile of tazemetostat and its metabolite (plasma) assessing AUC(0-∞)","dispersionType":"Standard Deviation","groups":[{"description":"Subjects with relapsed or refractory malignant mesothelioma regardless of BAP1 status were to be treated and PK blood samples collected after a single tazemetostat 800 mg dose on Cycle 1 Day 1 and after repeated twice daily doses of tazemetostat 800 mg on Cycle 1 Day 15. Subjects were to receive a single oral 800 mg tazemetostat dose on Cycle 1 Day 1. Starting on Cycle 1 Day 2, tazemetostat was orally administered at a dose of 800 mg twice daily.","id":"OG000","title":"Part 1 (Pharmacokinetics)"}],"paramType":"MEAN","reportingStatus":"POSTED","timeFrame":"Cycle 1 Day 15: pre-dose, 0.5, 1, 2, 4, 6, 8, 10, and 12 post-dose","title":"Part 1: Pharmacokinetics Profile of Tazemetostat and Its Metabolite (Plasma): AUC(0-∞)","type":"PRIMARY","unitOfMeasure":"h*ng/mL"}