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Crossover Population included participants from 'Crizotinib 250 mg BID' who crossed over to brigatinib following BIRC-assessed PD.","eventGroups":[{"deathsNumAffected":41,"deathsNumAtRisk":137,"description":"Brigatinib 90 mg, tablets, orally, QD for first 7 days followed by 180 mg, orally, QD, in each 28-day cycle until PD, intolerable toxicity, consent withdrawal, or death (The median duration of exposure was 34.86 months).","id":"EG000","otherNumAffected":132,"otherNumAtRisk":136,"seriousNumAffected":56,"seriousNumAtRisk":136,"title":"Randomized Phase: Brigatinib 90 mg QD/180 QD"},{"deathsNumAffected":29,"deathsNumAtRisk":138,"description":"Crizotinib 250 mg, tablets, BID in each 28-day cycle until disease progression, intolerable toxicity, consent withdrawal, or death (The median duration of exposure was 9.26 months).","id":"EG001","otherNumAffected":135,"otherNumAtRisk":137,"seriousNumAffected":53,"seriousNumAtRisk":137,"title":"Randomized Phase: Crizotinib 250 mg BID"},{"deathsNumAffected":22,"deathsNumAtRisk":65,"description":"Participants who experienced PD as assessed by the BIRC or received radiotherapy to the brain while on 'Crizotinib 250 mg BID' therapy in Randomized Phase were crossed over. Following 10-day washout period, crossover participants received brigatinib 90 mg, tablets, orally, QD for first 7 days followed by 180 mg, tablets, orally, QD in each 28-day cycle up to end of the study (The median duration of exposure was 17.25 months).","id":"EG002","otherNumAffected":63,"otherNumAtRisk":65,"seriousNumAffected":24,"seriousNumAtRisk":65,"title":"Crossover Phase: Brigatinib 90 mg QD/180 mg QD"}],"frequencyThreshold":"5","otherEvents":[{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"MedDRA 23.0","stats":[{"groupId":"EG000","numAffected":18,"numAtRisk":136},{"groupId":"EG001","numAffected":12,"numAtRisk":137},{"groupId":"EG002","numAffected":6,"numAtRisk":65}],"term":"Upper Respiratory Tract Infection"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"MedDRA 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