{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"44","value":"2880"},{"groupId":"OG001","spread":"22","value":"2678"},{"groupId":"OG002","spread":"35","value":"2649"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"6"},{"groupId":"OG001","value":"4"},{"groupId":"OG002","value":"9"}],"units":"Participants"}],"description":"Cmax is maximum plasma concentration of paclitaxel. The LLQ of paclitaxel was 10.0 ng/mL.","dispersionType":"Geometric Coefficient of Variation","groups":[{"description":"In chemotherapy phase, participants received paclitaxel once every three weeks (Q3W) (or once weekly \\[QW\\] on Days 1, 8 and 15), followed by carboplatin Q3W on Day 1 of each 21 day cycle for 6 cycles. During the maintenance phase, participants received avelumab once every 2 weeks (Q2W) on Days 1, 15 and 29 of each 42 day cycle.","id":"OG000","title":"PK: Chemotherapy Followed by Avelumab"},{"description":"In chemotherapy phase, participants received paclitaxel Q3W (or QW on Days 1, 8 and 15), followed by carboplatin Q3W along with avelumab Q3W on Day 1 of each 21 day cycle for 6 cycles. During the maintenance phase, participants received avelumab Q2W (on Days 1, 15 and 29 of each 42 day cycle).","id":"OG001","title":"PK: Chemotherapy + Avelumab Followed by Avelumab"},{"description":"In chemotherapy phase, participants received paclitaxel Q3W (or QW on Day 1, 8 and 15), followed by carboplatin Q3W on Day 1 of each 21 day cycle for 6 cycles.","id":"OG002","title":"PK: Chemotherapy Followed by Observation"}],"paramType":"GEOMETRIC_MEAN","populationDescription":"Paclitaxel PK parameter analysis set: all participants who received at least one dose of study drug and who had at least one of the PK parameters of interest for paclitaxel. Here \"Overall number of participants analyzed\" signifies participants who received Paclitaxel infusion on QW regimen and had data available for this outcome measure.","reportingStatus":"POSTED","timeFrame":"Pre-dose and at 1, 3, 4, 5, 6, 10, and 24 hours post paclitaxel infusion on Day 1 of Cycle 2","title":"Chemotherapy Phase: Maximum Plasma Concentration (Cmax) of Paclitaxel (Once a Week [QW] Regimen)","type":"SECONDARY","unitOfMeasure":"ng/mL"}