{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0.967","upperLimit":"3.93","value":"2.45"},{"groupId":"OG001","lowerLimit":"0.867","upperLimit":"24.0","value":"1.98"},{"groupId":"OG002","lowerLimit":"2.00","upperLimit":"24.3","value":"3.49"},{"groupId":"OG003","lowerLimit":"3.00","upperLimit":"46.4","value":"5.48"},{"groupId":"OG004","lowerLimit":"2.08","upperLimit":"48.8","value":"3.08"},{"groupId":"OG005","lowerLimit":"1.12","upperLimit":"4.00","value":"3.04"},{"groupId":"OG006","lowerLimit":"2.42","upperLimit":"7.77","value":"3.98"},{"groupId":"OG007","lowerLimit":"2.00","upperLimit":"4.20","value":"3.95"},{"groupId":"OG008","lowerLimit":"2.00","upperLimit":"49.8","value":"2.25"},{"groupId":"OG009","lowerLimit":"0.467","upperLimit":"7.78","value":"3.03"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"4"},{"groupId":"OG004","value":"7"},{"groupId":"OG005","value":"6"},{"groupId":"OG006","value":"10"},{"groupId":"OG007","value":"3"},{"groupId":"OG008","value":"5"},{"groupId":"OG009","value":"12"}],"units":"Participants"}],"title":"Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"4.00","upperLimit":"7.85","value":"5.93"},{"groupId":"OG001","lowerLimit":"1.00","upperLimit":"4.83","value":"4.02"},{"groupId":"OG002","lowerLimit":"2.13","upperLimit":"8.00","value":"4.05"},{"groupId":"OG003","lowerLimit":"2.17","upperLimit":"3.02","value":"3.00"},{"groupId":"OG004","lowerLimit":"1.58","upperLimit":"4.03","value":"2.59"},{"groupId":"OG005","lowerLimit":"1.87","upperLimit":"3.15","value":"2.55"},{"groupId":"OG006","lowerLimit":"1.00","upperLimit":"7.62","value":"2.98"},{"groupId":"OG007","lowerLimit":"3.00","upperLimit":"7.50","value":"5.25"},{"groupId":"OG008","lowerLimit":"2.05","upperLimit":"3.15","value":"2.17"},{"groupId":"OG009","lowerLimit":"2.00","upperLimit":"4.15","value":"2.18"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"5"},{"groupId":"OG003","value":"3"},{"groupId":"OG004","value":"6"},{"groupId":"OG005","value":"4"},{"groupId":"OG006","value":"8"},{"groupId":"OG007","value":"2"},{"groupId":"OG008","value":"5"},{"groupId":"OG009","value":"6"}],"units":"Participants"}],"title":"Day 15"}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"4"},{"groupId":"OG004","value":"8"},{"groupId":"OG005","value":"6"},{"groupId":"OG006","value":"11"},{"groupId":"OG007","value":"4"},{"groupId":"OG008","value":"6"},{"groupId":"OG009","value":"12"}],"units":"Participants"}],"description":"Tmax is the time to reach maximum (peak) plasma, blood, serum, or other body fluid drug concentration after single dose administration.","dispersionType":"Full Range","groups":[{"description":"Participants received 45 mg LTT462 QD as oral capsules.","id":"OG000","title":"LTT462 45 mg QD"},{"description":"Participants received 100 mg LTT462 QD as oral capsules.","id":"OG001","title":"LTT462 100 mg QD"},{"description":"Participants received 150 mg LTT462 QD as oral capsules.","id":"OG002","title":"LTT462 150 mg QD"},{"description":"Participants received 200 mg LTT462 QD as oral capsules.","id":"OG003","title":"LTT462 200 mg QD"},{"description":"Participants received 300 mg LTT462 QD as oral capsules.","id":"OG004","title":"LTT462 300 mg QD"},{"description":"Participants received 400 mg LTT462 QD as oral capsules.","id":"OG005","title":"LTT462 400 mg QD"},{"description":"Participants received 450 mg LTT462 QD as oral capsules.","id":"OG006","title":"LTT462 450 mg QD"},{"description":"Participants received 600 mg LTT462 QD as oral capsules.","id":"OG007","title":"LTT462 600 mg QD"},{"description":"Participants received 150 mg LTT462 twice daily (BID) as oral capsules.","id":"OG008","title":"LTT462 150 mg BID"},{"description":"Participants received 200 mg LTT462 BID as oral capsules.","id":"OG009","title":"LTT462 200 mg BID"}],"paramType":"MEDIAN","populationDescription":"PAS included of all participants who have at least 1 PK blood sample providing measurable LTT462 and received at least 1 dose of study drug, didn't vomit within 4 hours postdose, had at least 1 primary PK parameter. Here 'n' number analyzed signifies number of participants who were evaluable at each time point.","reportingStatus":"POSTED","timeFrame":"day 1, day 15","title":"The Time to Reach Maximum (Peak) Plasma, Blood, Serum, or Other Body Fluid Drug Concentration (Tmax) After Single Dose Administration of LTT462","type":"SECONDARY","unitOfMeasure":"hour"}