{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"55.9","value":"61.3"},{"groupId":"OG001","spread":"38.8","value":"134"},{"groupId":"OG002","spread":"230.9","value":"218"},{"groupId":"OG003","spread":"126.8","value":"494"},{"groupId":"OG004","spread":"127.4","value":"717"},{"groupId":"OG005","spread":"60.8","value":"1580"},{"groupId":"OG006","spread":"83.5","value":"1420"},{"groupId":"OG007","spread":"47.7","value":"1280"},{"groupId":"OG008","spread":"83.0","value":"598"},{"groupId":"OG009","spread":"73.8","value":"575"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"4"},{"groupId":"OG004","value":"7"},{"groupId":"OG005","value":"6"},{"groupId":"OG006","value":"10"},{"groupId":"OG007","value":"3"},{"groupId":"OG008","value":"5"},{"groupId":"OG009","value":"12"}],"units":"Participants"}],"title":"Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"29.9","value":"139"},{"groupId":"OG001","spread":"82.5","value":"938"},{"groupId":"OG002","spread":"69.0","value":"707"},{"groupId":"OG003","spread":"92.4","value":"972"},{"groupId":"OG004","spread":"131.9","value":"1330"},{"groupId":"OG005","spread":"83.3","value":"2370"},{"groupId":"OG006","spread":"49.7","value":"3470"},{"groupId":"OG007","spread":"248.8","value":"1030"},{"groupId":"OG008","spread":"58.5","value":"1390"},{"groupId":"OG009","spread":"108.0","value":"1510"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"5"},{"groupId":"OG003","value":"3"},{"groupId":"OG004","value":"6"},{"groupId":"OG005","value":"4"},{"groupId":"OG006","value":"8"},{"groupId":"OG007","value":"2"},{"groupId":"OG008","value":"5"},{"groupId":"OG009","value":"6"}],"units":"Participants"}],"title":"Day 15"}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"4"},{"groupId":"OG004","value":"8"},{"groupId":"OG005","value":"6"},{"groupId":"OG006","value":"11"},{"groupId":"OG007","value":"4"},{"groupId":"OG008","value":"6"},{"groupId":"OG009","value":"12"}],"units":"Participants"}],"description":"Cmax is the maximum (peak) observed plasma, blood, serum, or other body fluid drug concentration after single dose administration expressed in mass x volume-1.","dispersionType":"Geometric Coefficient of Variation","groups":[{"description":"Participants received 45 mg LTT462 QD as oral capsules.","id":"OG000","title":"LTT462 45 mg QD"},{"description":"Participants received 100 mg LTT462 QD as oral capsules.","id":"OG001","title":"LTT462 100 mg QD"},{"description":"Participants received 150 mg LTT462 QD as oral capsules.","id":"OG002","title":"LTT462 150 mg QD"},{"description":"Participants received 200 mg LTT462 QD as oral capsules.","id":"OG003","title":"LTT462 200 mg QD"},{"description":"Participants received 300 mg LTT462 QD as oral capsules.","id":"OG004","title":"LTT462 300 mg QD"},{"description":"Participants received 400 mg LTT462 QD as oral capsules.","id":"OG005","title":"LTT462 400 mg QD"},{"description":"Participants received 450 mg LTT462 QD as oral capsules.","id":"OG006","title":"LTT462 450 mg QD"},{"description":"Participants received 600 mg LTT462 QD as oral capsules.","id":"OG007","title":"LTT462 600 mg QD"},{"description":"Participants received 150 mg LTT462 twice daily (BID) as oral capsules.","id":"OG008","title":"LTT462 150 mg BID"},{"description":"Participants received 200 mg LTT462 BID as oral capsules.","id":"OG009","title":"LTT462 200 mg BID"}],"paramType":"GEOMETRIC_MEAN","populationDescription":"Pharmacokinetic (PK) analysis set (PAS) included of all participants who have at least 1 PK blood sample providing measurable LTT462 and received at least 1 dose of study drug, didn't vomit within 4 hours postdose, had at least 1 primary PK parameter. Here 'n' number analyzed signifies number of participants who were evaluable at each time point.","reportingStatus":"POSTED","timeFrame":"day 1, day 15","title":"The Maximum (Peak) Observed Plasma, Blood, Serum, or Other Body Fluid Drug Concentration (Cmax) After Single Dose Administration of LTT462","type":"SECONDARY","unitOfMeasure":"nanogram per milliliter (ng/mL)"}