{"calculatePct":false,"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"11"},{"groupId":"OG001","value":"13"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"51"},{"groupId":"OG001","value":"50"}],"units":"Participants"}],"description":"Estimate the proportion of subjects with plasma cell contamination (defined as \\>0.01% and at least 100 cellular events) of harvested stem cell product by multi parametric flow cytometry (MFC) from patients with myeloma undergoing autologous stem cell collection 1) by standard of care mobilization using Granulocyte colony-stimulating factor (G-CSF) with or without Mozobil and 2) after two doses of bortezomib as in vivo purging plus standard of care using G-CSF with or without Mozobil.","groups":[{"description":"Standard of Care Stem cell collection without in-vivo purging with Bortezomib. Standard of Care drugs Granulocyte colony-stimulating factor (G-CSF) +/- Mozobil (the latter if needed).\n\nNOTE: Multiparametric Flow Cytometry to be performed on samples for BOTH groups A and B\n\nGranulocyte colony-stimulating factor (G-CSF): Granulocyte colony-stimulating factor (G-CSF) will be given to all participants by injection under the skin 4 days and 1 day before stem cell collection, and then continued until the stem cell collection is completed.\n\nMozobil: Mozobil will be given to all participants by injection under the skin only if needed per Investigator.","id":"OG000","title":"Stem Cell Collection Without In-vivo Purging With Bortezomib"},{"description":"Bortezomib will be given subcutaneously (SQ) at 1.3 mg/m2 on day -11 and day -8 followed by Granulocyte colony-stimulating factor (G-CSF) given SQ on day -4 thru day -1 and continued until the collection is completed. Mozobil will be given if needed.\n\nThere must be at least 72 hours between each dose of bortezomib. NOTE: Multiparametric Flow Cytometry to be performed on samples for BOTH groups A and B\n\nBortezomib: Bortezomib will be given to Group B participants by injection under the skin 11 days and 8 days before stem cell collection.\n\nGranulocyte colony-stimulating factor (G-CSF): Granulocyte colony-stimulating factor (G-CSF) will be given to all participants by injection under the skin 4 days and 1 day before stem cell collection, and then continued until the stem cell collection is completed.\n\nMozobil: Mozobil will be given to all participants by injection under the skin only if needed per Investigator.","id":"OG001","title":"Stem Cell Collection With In-vivo Purging With Bortezomib"}],"paramType":"COUNT_OF_PARTICIPANTS","reportingStatus":"POSTED","timeFrame":"Day 0 for all subjects (Day 0 is the day of stem cell collection)","title":"Multiparametric Flow Cytometry - Minimum Residual Disease","type":"PRIMARY","unitOfMeasure":"Participants"}