{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"2.99","upperLimit":"8.84","value":"6.05"},{"groupId":"OG001","lowerLimit":"2.60","upperLimit":"11.07","value":"6.97"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"35"},{"groupId":"OG001","value":"16"}],"units":"Participants"}],"description":"EFS was the time interval from randomization to death, disease progression, or lack of complete response (CR) or partial response (PR) after 3 cycles of treatment, whichever occurred first based on blinded independent event review by the Independent Review Committee (IRC). CR was defined as computed tomography (CT) or magnetic resonance imaging (MRI) reveals no residual disease or new lesions, resected residual mass that was pathologically (morphologically) negative for disease, BM and CSF morphologically free of disease with no new lesions by imaging examination. PR was defined as 50 percent (%) decrease in sum of the products of the lesion diameters (SPD) on CT or MRI; fluorodeoxyglucose (FDG)-positron emission tomography (PET) may be positive, no new or progressive disease (PD); morphologic evidence of disease may be present in BM or cerebrospinal fluid (CSF) if present at diagnosis; however, there should be 50% reduction in percentage of lymphoma cells.","dispersionType":"95% Confidence Interval","groups":[{"description":"Participants received ibrutinib based on age group and BSA in combination with CIT (investigator choice of RICE or RVICI) until 3 treatment cycles, transplantation if indicated, or until progressive disease (PD) or unacceptable toxicity. For both regimens, triple intrathecal therapy consisting of methotrexate, corticosteroid, and cytarabine will be administered for central nervous system (CNS) prophylaxis in age-appropriate dosing. Participants of age groups 1-5 years and 6-11 years received ibrutinib 440 mg/m\\^2, and age group 12-17 years received Ibrutinib 329 mg/m\\^2 (dose selected from Part 1).","id":"OG000","title":"Part 2: Ibrutinib+CIT (RICE or RVICI)"},{"description":"Participants received CIT (investigator choice of RICE or RVICI) alone based on age group and BSA until 3 treatment cycles, transplantation if indicated, or until PD or unacceptable toxicity. For both regimens, triple intrathecal therapy consisting of methotrexate, corticosteroid, and cytarabine will be administered for CNS prophylaxis in age-appropriate dosing. The RICE regimen was composed of rituximab 750 mg/m\\^2, ifosfamide 9 g/m2, carboplatin 635 mg/m\\^2, etoposide 300 mg/m\\^2, and dexamethasone 100 mg/m\\^2. The RVICI regimen was composed of rituximab 750 mg/m\\^2, vincristine 1.6 mg/m\\^2, idarubicin 20 mg/m\\^2, carboplatin 800 mg/m\\^2, ifosfamide 10 g/m\\^2, and dexamethasone 100 mg/m\\^2 (all doses represented as cumulative administered in 1 cycle).","id":"OG001","title":"Part 2: Chemoimmunotherapy"}],"paramType":"MEDIAN","populationDescription":"The intent-to-treat (ITT) population consisted of all randomized participants; participants analyzed based on randomization, regardless of study drug received. Here 'N' (number of participants analyzed) signifies number of participants who were evaluable for this outcome measure.","reportingStatus":"POSTED","timeFrame":"Time from Randomization to death, disease progression, or lack of CR or PR after 3 cycles of treatment (up to 4 year and 4 months)","title":"Part 2: Event Free Survival (EFS) Between the 2 Treatment Groups","type":"PRIMARY","unitOfMeasure":"Months"}