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1 day 1"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1490","upperLimit":"4080","value":"1780"},{"groupId":"OG001","lowerLimit":"2340","upperLimit":"5420","value":"3800"},{"groupId":"OG002","lowerLimit":"1290","upperLimit":"4910","value":"3570"},{"groupId":"OG003","lowerLimit":"7020","upperLimit":"9520","value":"8270"},{"groupId":"OG004","lowerLimit":"11200","upperLimit":"12900","value":"11800"},{"groupId":"OG005","lowerLimit":"27300","upperLimit":"27300","value":"27300"},{"groupId":"OG006","lowerLimit":"2890","upperLimit":"8400","value":"6500"},{"groupId":"OG007","lowerLimit":"6770","upperLimit":"42600","value":"7980"},{"groupId":"OG008","lowerLimit":"0.00","upperLimit":"16600","value":"5230"},{"groupId":"OG009","lowerLimit":"4590","upperLimit":"32000","value":"7670"},{"groupId":"OG014","lowerLimit":"2760","upperLimit":"16100","value":"6280"},{"groupId":"OG015","lowerLimit":"4620","upperLimit":"21600","value":"7250"},{"groupId":"OG016","lowerLimit":"4340","upperLimit":"128000","value":"6910"},{"groupId":"OG027","lowerLimit":"0.00","upperLimit":"23500","value":"4200"},{"groupId":"OG028","lowerLimit":"3440","upperLimit":"143000","value":"7050"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"4"},{"groupId":"OG003","value":"2"},{"groupId":"OG004","value":"3"},{"groupId":"OG005","value":"1"},{"groupId":"OG006","value":"3"},{"groupId":"OG007","value":"4"},{"groupId":"OG008","value":"5"},{"groupId":"OG009","value":"5"},{"groupId":"OG010","value":"0"},{"groupId":"OG011","value":"0"},{"groupId":"OG012","value":"0"},{"groupId":"OG013","value":"0"},{"groupId":"OG014","value":"5"},{"groupId":"OG015","value":"5"},{"groupId":"OG016","value":"5"},{"groupId":"OG017","value":"0"},{"groupId":"OG018","value":"0"},{"groupId":"OG019","value":"0"},{"groupId":"OG020","value":"0"},{"groupId":"OG021","value":"0"},{"groupId":"OG022","value":"0"},{"groupId":"OG023","value":"0"},{"groupId":"OG024","value":"0"},{"groupId":"OG025","value":"0"},{"groupId":"OG026","value":"0"},{"groupId":"OG027","value":"10"},{"groupId":"OG028","value":"11"}],"units":"Participants"}],"title":"Cycle 1 day 2"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1140","upperLimit":"2930","value":"1740"},{"groupId":"OG001","lowerLimit":"1660","upperLimit":"4510","value":"3830"},{"groupId":"OG002","lowerLimit":"1590","upperLimit":"4840","value":"3250"},{"groupId":"OG003","lowerLimit":"3910","upperLimit":"6470","value":"5650"},{"groupId":"OG004","lowerLimit":"9740","upperLimit":"11300","value":"10200"},{"groupId":"OG005","lowerLimit":"39400","upperLimit":"39400","value":"39400"},{"groupId":"OG006","lowerLimit":"10300","upperLimit":"25000","value":"17700"},{"groupId":"OG007","lowerLimit":"10600","upperLimit":"80300","value":"18400"},{"groupId":"OG008","lowerLimit":"14700","upperLimit":"22200","value":"18700"},{"groupId":"OG009","lowerLimit":"28500","upperLimit":"35300","value":"31900"},{"groupId":"OG010","lowerLimit":"10600","upperLimit":"26700","value":"16100"},{"groupId":"OG011","lowerLimit":"13800","upperLimit":"17200","value":"15000"},{"groupId":"OG012","lowerLimit":"23800","upperLimit":"23800","value":"23800"},{"groupId":"OG013","lowerLimit":"26700","upperLimit":"41900","value":"37600"},{"groupId":"OG014","lowerLimit":"2660","upperLimit":"12200","value":"5580"},{"groupId":"OG015","lowerLimit":"6570","upperLimit":"27200","value":"8500"},{"groupId":"OG016","lowerLimit":"7140","upperLimit":"187000","value":"12700"},{"groupId":"OG017","lowerLimit":"11400","upperLimit":"12900","value":"12200"},{"groupId":"OG018","lowerLimit":"2520","upperLimit":"5420","value":"3770"},{"groupId":"OG019","lowerLimit":"28.6","upperLimit":"21300","value":"6300"},{"groupId":"OG020","lowerLimit":"0.00","upperLimit":"15100","value":"11100"},{"groupId":"OG021","lowerLimit":"5730","upperLimit":"8610","value":"6020"},{"groupId":"OG022","lowerLimit":"1230","upperLimit":"18900","value":"1850"},{"groupId":"OG027","lowerLimit":"0.00","upperLimit":"13500","value":"4710"},{"groupId":"OG028","lowerLimit":"0.00","upperLimit":"311000","value":"12700"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"4"},{"groupId":"OG003","value":"3"},{"groupId":"OG004","value":"3"},{"groupId":"OG005","value":"1"},{"groupId":"OG006","value":"2"},{"groupId":"OG007","value":"4"},{"groupId":"OG008","value":"5"},{"groupId":"OG009","value":"3"},{"groupId":"OG010","value":"3"},{"groupId":"OG011","value":"3"},{"groupId":"OG012","value":"1"},{"groupId":"OG013","value":"3"},{"groupId":"OG014","value":"3"},{"groupId":"OG015","value":"5"},{"groupId":"OG016","value":"3"},{"groupId":"OG017","value":"2"},{"groupId":"OG018","value":"4"},{"groupId":"OG019","value":"3"},{"groupId":"OG020","value":"4"},{"groupId":"OG021","value":"4"},{"groupId":"OG022","value":"6"},{"groupId":"OG023","value":"0"},{"groupId":"OG024","value":"0"},{"groupId":"OG025","value":"0"},{"groupId":"OG026","value":"0"},{"groupId":"OG027","value":"9"},{"groupId":"OG028","value":"12"}],"units":"Participants"}],"title":"Cycle 1 day 8"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"34.7","upperLimit":"4070","value":"2810"},{"groupId":"OG001","lowerLimit":"2010","upperLimit":"6780","value":"3830"},{"groupId":"OG002","lowerLimit":"824","upperLimit":"7130","value":"4480"},{"groupId":"OG003","lowerLimit":"6010","upperLimit":"7230","value":"6400"},{"groupId":"OG004","lowerLimit":"11000","upperLimit":"14100","value":"11400"},{"groupId":"OG005","lowerLimit":"27300","upperLimit":"27300","value":"27300"},{"groupId":"OG006","lowerLimit":"13700","upperLimit":"29400","value":"15900"},{"groupId":"OG007","lowerLimit":"91100","upperLimit":"91100","value":"91100"},{"groupId":"OG008","lowerLimit":"11900","upperLimit":"22900","value":"19800"},{"groupId":"OG009","lowerLimit":"7030","upperLimit":"21600","value":"21100"},{"groupId":"OG014","lowerLimit":"2700","upperLimit":"10800","value":"9530"},{"groupId":"OG015","lowerLimit":"6490","upperLimit":"10800","value":"8670"},{"groupId":"OG016","lowerLimit":"7230","upperLimit":"34900","value":"12100"},{"groupId":"OG027","lowerLimit":"1850","upperLimit":"26700","value":"6880"},{"groupId":"OG028","lowerLimit":"40.1","upperLimit":"52600","value":"14300"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"4"},{"groupId":"OG003","value":"3"},{"groupId":"OG004","value":"3"},{"groupId":"OG005","value":"1"},{"groupId":"OG006","value":"3"},{"groupId":"OG007","value":"1"},{"groupId":"OG008","value":"5"},{"groupId":"OG009","value":"5"},{"groupId":"OG010","value":"0"},{"groupId":"OG011","value":"0"},{"groupId":"OG012","value":"0"},{"groupId":"OG013","value":"0"},{"groupId":"OG014","value":"3"},{"groupId":"OG015","value":"4"},{"groupId":"OG016","value":"3"},{"groupId":"OG017","value":"0"},{"groupId":"OG018","value":"0"},{"groupId":"OG019","value":"0"},{"groupId":"OG020","value":"0"},{"groupId":"OG021","value":"0"},{"groupId":"OG022","value":"0"},{"groupId":"OG023","value":"0"},{"groupId":"OG024","value":"0"},{"groupId":"OG025","value":"0"},{"groupId":"OG026","value":"0"},{"groupId":"OG027","value":"4"},{"groupId":"OG028","value":"7"}],"units":"Participants"}],"title":"Cycle 1 day 9"},{"categories":[{"measurements":[{"groupId":"OG022","lowerLimit":"838","upperLimit":"29300","value":"2140"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"},{"groupId":"OG004","value":"0"},{"groupId":"OG005","value":"0"},{"groupId":"OG006","value":"0"},{"groupId":"OG007","value":"0"},{"groupId":"OG008","value":"0"},{"groupId":"OG009","value":"0"},{"groupId":"OG010","value":"0"},{"groupId":"OG011","value":"0"},{"groupId":"OG012","value":"0"},{"groupId":"OG013","value":"0"},{"groupId":"OG014","value":"0"},{"groupId":"OG015","value":"0"},{"groupId":"OG016","value":"0"},{"groupId":"OG017","value":"0"},{"groupId":"OG018","value":"0"},{"groupId":"OG019","value":"0"},{"groupId":"OG020","value":"0"},{"groupId":"OG021","value":"0"},{"groupId":"OG022","value":"7"},{"groupId":"OG023","value":"0"},{"groupId":"OG024","value":"0"},{"groupId":"OG025","value":"0"},{"groupId":"OG026","value":"0"},{"groupId":"OG027","value":"0"},{"groupId":"OG028","value":"0"}],"units":"Participants"}],"title":"Cycle 1 day 15"}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"4"},{"groupId":"OG003","value":"3"},{"groupId":"OG004","value":"3"},{"groupId":"OG005","value":"2"},{"groupId":"OG006","value":"3"},{"groupId":"OG007","value":"4"},{"groupId":"OG008","value":"5"},{"groupId":"OG009","value":"5"},{"groupId":"OG010","value":"3"},{"groupId":"OG011","value":"3"},{"groupId":"OG012","value":"2"},{"groupId":"OG013","value":"3"},{"groupId":"OG014","value":"5"},{"groupId":"OG015","value":"5"},{"groupId":"OG016","value":"5"},{"groupId":"OG017","value":"2"},{"groupId":"OG018","value":"4"},{"groupId":"OG019","value":"3"},{"groupId":"OG020","value":"4"},{"groupId":"OG021","value":"4"},{"groupId":"OG022","value":"9"},{"groupId":"OG023","value":"0"},{"groupId":"OG024","value":"0"},{"groupId":"OG025","value":"0"},{"groupId":"OG026","value":"0"},{"groupId":"OG027","value":"10"},{"groupId":"OG028","value":"13"}],"units":"Participants"}],"description":"Plasma concentrations of AMG 176 were determined using a validated assay. Noncompartmental analysis was performed for estimation of pharmacokinetic (PK) parameters. Concentrations below the lower limit of quantification (LLOQ) of 5.00 ng/mL were set to zero before data analysis.","dispersionType":"Full Range","groups":[{"description":"Participants with MM received AMG 176 Dose A BIW. AMG 176 was administered as an IV infusion in a 4-week cycle.","id":"OG000","title":"Part 1A Cohort 1 (MM): AMG 176 Dose A BIW"},{"description":"Participants with MM received AMG 176 Dose B IV BIW. AMG 176 was administered as an IV infusion in a 4-week cycle.","id":"OG001","title":"Part 1A Cohort 2 (MM): AMG 176 Dose B BIW"},{"description":"Participants with MM received AMG 176 Dose C BIW. AMG 176 was administered as an IV infusion in a 4-week cycle.","id":"OG002","title":"Part 1A Cohort 3 (MM): AMG 176 Dose C BIW"},{"description":"Participants with MM received AMG 176 Dose D BIW. AMG 176 was administered as an IV infusion in a 4-week cycle.","id":"OG003","title":"Part 1A Cohort 4 (MM): AMG 176 Dose D BIW"},{"description":"Participants with MM received AMG 176 Dose E BIW. AMG 176 was administered as an IV infusion in a 4-week cycle.","id":"OG004","title":"Part 1A Cohort 5 (MM): AMG 176 Dose E BIW"},{"description":"Participants with MM received AMG 176 Dose G BIW. AMG 176 was administered as an IV infusion in a 4-week cycle.","id":"OG005","title":"Part 1A Cohort 6 (MM): AMG 176 Dose G BIW"},{"description":"Participants with MM received AMG 176 Dose E in cycle 1 week 1, then received Dose F BIW. AMG 176 was administered as an IV infusion in a 4-week cycle.","id":"OG006","title":"Part 1A Cohort 7 (MM): AMG 176 Dose E Then Dose F BIW"},{"description":"Participants with MM received AMG 176 Dose E in cycle 1 week 1, then received Dose G BIW. AMG 176 was administered as an IV infusion in a 4-week cycle.","id":"OG007","title":"Part 1A Cohort 8 (MM): AMG 176 Dose E Then Dose G BIW"},{"description":"Participants with MM received AMG 176 Dose E in cycle 1 week 1, then received Dose H BIW. AMG 176 was administered as an IV infusion in a 4-week cycle.","id":"OG008","title":"Part 1A Cohort 9 (MM): AMG 176 Dose E Then Dose H BIW"},{"description":"Participants with MM received AMG 176 Dose E in cycle 1 week 1, then received Dose I BIW. AMG 176 was administered as an IV infusion in a 4-week cycle.","id":"OG009","title":"Part 1A Cohort 10 (MM): AMG 176 Dose E Then Dose I BIW"},{"description":"Participants with MM received AMG 176 Dose E in cycle 1 week 1, then received Dose F QW. AMG 176 was administered as an IV infusion in a 4-week cycle.","id":"OG010","title":"Part 1B Cohort 1 (MM): AMG 176 Dose E Then Dose F QW"},{"description":"Participants with MM received AMG 176 Dose E in cycle 1 week 1, then received Dose G QW. AMG 176 was administered as an IV infusion in a 4-week cycle.","id":"OG011","title":"Part 1B Cohort 2 (MM): AMG 176 Dose E Then Dose G QW"},{"description":"Participants with MM received AMG 176 Dose E in cycle 1 week 1, then received Dose H QW. AMG 176 was administered as an IV infusion in a 4-week cycle.","id":"OG012","title":"Part 1B Cohort 3 (MM): AMG 176 Dose E Then Dose H QW"},{"description":"Participants with MM received AMG 176 Dose E in cycle 1 week 1, then received Dose I QW. AMG 176 was administered as an IV infusion in a 4-week cycle.","id":"OG013","title":"Part 1B Cohort 4 (MM): AMG 176 Dose E Then Dose I QW"},{"description":"Participants with AML received AMG 176 Dose D BIW. AMG 176 was administered as an IV infusion in a 4-week cycle.","id":"OG014","title":"Part 3A Cohort 1 (AML): AMG 176 Dose D BIW"},{"description":"Participants with AML received AMG 176 Dose E BIW. AMG 176 was administered as an IV infusion in a 4-week cycle.","id":"OG015","title":"Part 3A Cohort 2 (AML): AMG 176 Dose E BIW"},{"description":"Participants with AML received AMG 176 Dose E in cycle 1 week 1, then received Dose F BIW. AMG 176 was administered as an IV infusion in a 4-week cycle.","id":"OG016","title":"Part 3A Cohort 3 (AML): AMG 176 Dose E Then Dose F BIW"},{"description":"Japanese participants with AML received AMG 176 Dose E in cycle 1 week 1, then received Dose F QW. AMG 176 was administered as an IV infusion in a 4-week cycle.","id":"OG017","title":"Part 3A Cohort 4 (Japanese Participants With AML): AMG 176 Dose E Then Dose F QW"},{"description":"Participants with AML received AMG 176 Dose E QW. AMG 176 was administered as an IV infusion in a 4-week cycle.","id":"OG018","title":"Part 3B Cohort 1 (AML): AMG 176 Dose E QW"},{"description":"Participants with AML received AMG 176 Dose E in cycle 1 week 1, then received Dose F QW. AMG 176 was administered as an IV infusion in a 4-week cycle.","id":"OG019","title":"Part 3B Cohort 2 (AML): AMG 176 Dose E Then Dose F QW"},{"description":"Participants with AML received AMG 176 Dose E in cycle 1 week 1, then received Dose G QW. AMG 176 was administered as an IV infusion in a 4-week cycle.","id":"OG020","title":"Part 3B Cohort 3 (AML): AMG 176 Dose E Then Dose G QW"},{"description":"Japanese participants with AML received AMG 176 Dose E QW. AMG 176 was administered as an IV infusion in a 4-week cycle.","id":"OG021","title":"Part 3C Cohort 1 (Japanese Participants With AML): AMG 176 Dose E QW"},{"description":"Participants with AML received AMG 176 Dose D QW. AMG 176 was administered as an IV infusion in a 4-week cycle. They also received 200 mg itraconazole QD for 7 days in week 1.","id":"OG022","title":"Part 3D Cohort 1 (AML): AMG 176 Dose D QW + Itraconazole"},{"description":"Participants with AML received AMG 176 Dose D QW. AMG 176 was administered as an IV infusion in a 4-week cycle. They also received 75 mg/m\\^2 azacitidine SC or IV QD for 7 days in week 1.","id":"OG023","title":"Part 4 Cohort 1 (AML): AMG 176 Dose D QW + Azacitidine"},{"description":"Participants with AML received AMG 176 Dose E QW. AMG 176 was administered as an IV infusion in a 4-week cycle. They also received 75 mg/m\\^2 azacitidine SC or IV QD for 7 days in week 1.","id":"OG024","title":"Part 4 Cohort 2 (AML): AMG 176 Dose E QW + Azacitidine"},{"description":"Participants with AML received AMG 176 Dose E in cycle 1 week 1, then received Dose F QW. AMG 176 was administered as an IV infusion in a 4-week cycle. They also received 75 mg/m\\^2 azacitidine SC or IV QD for 7 days in week 1.","id":"OG025","title":"Part 4 Cohort 3 (AML): AMG 176 Dose E Then Dose F QW + Azacitidine"},{"description":"Participants with AML received AMG 176 Dose E in cycle 1 week 1, then received Dose G QW. AMG 176 was administered as an IV infusion in a 4-week cycle. They also received 75 mg/m\\^2 azacitidine SC or IV QD for 7 days in week 1.","id":"OG026","title":"Part 4 Cohort 4 (AML): AMG 176 Dose E Then Dose G QW + Azacitidine"},{"description":"Participants with AML received AMG 176 Dose E BIW. AMG 176 was administered as an IV infusion in a 4-week cycle. They also received 75 mg/m\\^2 azacitidine SC or IV QD for 7 days in week 1.","id":"OG027","title":"Part 4 Cohort 5A (AML): AMG 176 Dose E BIW + Azacitidine"},{"description":"Participants with AML received AMG 176 Dose E in cycle 1 week 1, then received Dose G BIW. AMG 176 was administered as an IV infusion in a 4-week cycle. They also received 75 mg/m\\^2 azacitidine SC or IV QD for 7 days in week 1.","id":"OG028","title":"Part 4 Cohort 5B (AML): AMG 176 Dose E the Dose G BIW + Azacitidine"}],"paramType":"MEDIAN","populationDescription":"The PK analysis set included all participants who had received at least 1 dose of AMG 176 and had at least 1 PK sample collected. Participants with data available at each time point are presented.","reportingStatus":"POSTED","timeFrame":"Parts 1B, 3B, 3C, 3A (cohort 4) Cycle 1: day 1 pre, end of infusion (EOI), 1, 2, 3, 5, 7 hrs EOI, day 8 pre, EOI; Part 3D also days 9, 15 pre and EOI; Parts 1A, 3 (except cohort 4), 4: also day 2 pre, EOI, 1, 2, 3, 5, 7 hrs EOI, day 9 pre and EOI","title":"Maximum Observed Concentration (Cmax) of AMG 176","type":"PRIMARY","unitOfMeasure":"ng/mL"}