{"denomUnitsSelected":"Participants","description":"Continuous biomarker levels will be explored in a graphical manner including mean plots and plots of change and percent change from baseline and other summary measures. Any potential relationships between the baseline level or change in the level of each biomarker and clinical outcome such as overall response, 6-month progression and survival, and adverse event incidence will be further analyzed using Wilcoxon rank sum tests or logistic regression methods, as appropriate. Association between a dichotomized biomarker and overall response will be assessed using a chi-squared test.","reportingStatus":"NOT_POSTED","timeFrame":"Baseline to up to 113 days (after course 4)","title":"Change in Biomarker Levels","type":"OTHER_PRE_SPECIFIED"}