{"classes":[{"categories":[{"measurements":[{"groupId":"OG001","lowerLimit":"2.02","upperLimit":"2.02","value":"2.02"},{"groupId":"OG002","lowerLimit":"2.00","upperLimit":"4.08","value":"4.05"},{"groupId":"OG003","lowerLimit":"1.92","upperLimit":"2.65","value":"2.29"},{"groupId":"OG004","lowerLimit":"2.00","upperLimit":"4.10","value":"2.07"},{"groupId":"OG005","lowerLimit":"2.00","upperLimit":"3.98","value":"2.33"},{"groupId":"OG006","lowerLimit":"2.05","upperLimit":"3.63","value":"2.17"},{"groupId":"OG007","lowerLimit":"2.05","upperLimit":"3.00","value":"2.05"},{"groupId":"OG008","lowerLimit":"8.12","upperLimit":"92.9","value":"50.5"},{"groupId":"OG009","lowerLimit":"1.92","upperLimit":"1.92","value":"1.92"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"3"},{"groupId":"OG003","value":"2"},{"groupId":"OG004","value":"4"},{"groupId":"OG005","value":"5"},{"groupId":"OG006","value":"4"},{"groupId":"OG007","value":"3"},{"groupId":"OG008","value":"2"},{"groupId":"OG009","value":"1"}],"units":"Participants"}],"title":"Cycle 1 Day 1"},{"categories":[{"measurements":[{"groupId":"OG001","lowerLimit":"2.12","upperLimit":"2.12","value":"2.12"},{"groupId":"OG002","lowerLimit":"2.00","upperLimit":"4.22","value":"3.98"},{"groupId":"OG003","lowerLimit":"3.90","upperLimit":"3.90","value":"3.90"},{"groupId":"OG004","lowerLimit":"2.17","upperLimit":"4.28","value":"4.00"},{"groupId":"OG005","lowerLimit":"1.92","upperLimit":"2.17","value":"2.09"},{"groupId":"OG006","lowerLimit":"2.10","upperLimit":"2.17","value":"2.14"},{"groupId":"OG008","lowerLimit":"23.4","upperLimit":"25.7","value":"24.6"},{"groupId":"OG009","lowerLimit":"1.98","upperLimit":"1.98","value":"1.98"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"3"},{"groupId":"OG003","value":"1"},{"groupId":"OG004","value":"3"},{"groupId":"OG005","value":"4"},{"groupId":"OG006","value":"2"},{"groupId":"OG007","value":"0"},{"groupId":"OG008","value":"2"},{"groupId":"OG009","value":"1"}],"units":"Participants"}],"title":"Cycle 2 Day 1"}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"3"},{"groupId":"OG003","value":"2"},{"groupId":"OG004","value":"4"},{"groupId":"OG005","value":"5"},{"groupId":"OG006","value":"4"},{"groupId":"OG007","value":"3"},{"groupId":"OG008","value":"2"},{"groupId":"OG009","value":"1"}],"units":"Participants"}],"description":"Time for Maximum serum concentration (Tmax) of PF-06671008 was observed directly from data as time of first occurrence.","dispersionType":"Full Range","groups":[{"description":"PF-06671008 was administered as a weekly intravenous (IV) infusion in 21-day cycles at 1.5 ng/kg. PF-06671008 was administered for up to 4 cycles in this cohort.","id":"OG000","title":"PF-06671008 1.5 ng/kg IV"},{"description":"PF-06671008 was administered as a weekly IV infusion in 21-day cycles at 7.5 ng/kg. PF-06671008 was administered for up to 3 cycles in this cohort.","id":"OG001","title":"PF-06671008 7.5 ng/kg IV"},{"description":"PF-06671008 was administered as a weekly IV infusion in 21-day cycles at 20 ng/kg. PF-06671008 was administered for up to 4 cycles in this cohort.","id":"OG002","title":"PF-06671008 20 ng/kg IV"},{"description":"PF-06671008 was administered as a weekly IV infusion in 21-day cycles at 50 ng/kg. PF-06671008 was administered for up to 2 cycles in this cohort.","id":"OG003","title":"PF-06671008 50 ng/kg IV"},{"description":"PF-06671008 was administered as a weekly IV infusion in 21-day cycles at 100 ng/kg. PF-06671008 was administered for up to 4 cycles in this cohort.","id":"OG004","title":"PF-06671008 100 ng/kg IV"},{"description":"PF-06671008 was administered as a weekly IV infusion in 21-day cycles at 200 ng/kg. PF-06671008 was administered for up to 16 cycles in this cohort.","id":"OG005","title":"PF-06671008 200 ng/kg IV"},{"description":"PF-06671008 was administered as a weekly IV infusion in 21-day cycles at 300 ng/kg. PF-06671008 was administered for up to 4 cycles in this cohort.","id":"OG006","title":"PF-06671008 300 ng/kg IV"},{"description":"PF-06671008 was administered as a weekly IV infusion in 21-day cycles at 400 ng/kg. PF-06671008 was administered for up to 2 cycles in this cohort.","id":"OG007","title":"PF-06671008 400 ng/kg IV"},{"description":"PF-06671008 was administered as a weekly subcutaneous (SC) injection in 21-day cycles at 200 ng/kg. PF-06671008 was administered for up to 5 cycles in this cohort.","id":"OG008","title":"PF-06671008 200 ng/kg SC"},{"description":"PF-06671008 was administered as a weekly IV infusion in 21-day cycles at a priming dose of 200 ng/kg on Cycle 1 Day 1 (C1D1) and 300 ng/kg for all subsequent dosing. PF-06671008 was administered for up to 4 cycles in this cohort.","id":"OG009","title":"PF-06671008 200 ng/kg Prime and 300 ng/kg Maintenance IV"}],"paramType":"MEDIAN","populationDescription":"All enrolled participants treated who had sufficient information to estimate at least 1 of the PK parameters of interest and who had no major protocol deviations influencing the PK assessment.","reportingStatus":"POSTED","timeFrame":"C1D1 0, 1, 2, 4, 8, 24, 48, 72 and 96 hrs post-dose, C2D1 0, 2, 4, 8, 24, 48, 72 and 96 hrs post-dose","title":"Time to Reach Maximum Observed Serum Concentration (Tmax) of PF-06671008","type":"SECONDARY","unitOfMeasure":"hours"}