{"analyses":[{"ciLowerLimit":"0.60","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"3.94","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY","pValue":"0.3529","paramType":"Risk Ratio (RR)","paramValue":"1.54","statisticalMethod":"Cochran-Mantel-Haenszel"}],"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"7"},{"groupId":"OG001","value":"6"}]}],"title":"Response"},{"categories":[{"measurements":[{"groupId":"OG000","value":"6"},{"groupId":"OG001","value":"12"}]}],"title":"Non-Response (Stable, Progression)"}],"denoms":[{"counts":[{"groupId":"OG000","value":"13"},{"groupId":"OG001","value":"18"}],"units":"Participants"}],"description":"Proteinuria and estimated Glomerular Filtration Rate (eGFR) response (Response or Non-Response \\[Stable, Progression\\]) from baseline through 12 months of treatment in subjects with renal involvement. Renal best response, as assessed by proteinuria, is defined as the most favorable category among response (ie, ≥30% decrease from baseline or \\<0.5 g/24 hours postbaseline result if subject does not meet criteria for progression), stable (ie, neither response nor progression), and progression (ie, ≥25% decrease in eGFR from baseline) across all visits after the first infusion of study drug up to and through the end of the study. Subjects are considered non-responders until a response is achieved. Assessments that qualify as both a response and progression are counted as progression.\n\nNon-response is defined as either stable or progression.","groups":[{"description":"NEOD001, 24 mg/kg IV every 4 weeks for 12 months","id":"OG000","title":"NEOD001 24 mg/kg"},{"description":"Placebo, 0.9% Saline IV every 4 weeks for 12 months","id":"OG001","title":"Placebo"}],"paramType":"COUNT_OF_PARTICIPANTS","populationDescription":"Renal Evaluable Population","reportingStatus":"POSTED","timeFrame":"Baseline through 12 months of treatment","title":"Number of Participants With Renal Best Response and Non-Response","type":"SECONDARY","unitOfMeasure":"Participants"}