{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"41.2","value":"0.516"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"153"},{"groupId":"OG001","value":"0"}],"units":"Participants"}],"description":"Apparent total plasma clearance was calculated as Dose/Area Under the Curve to infinity (ꝏ).","dispersionType":"Geometric Coefficient of Variation","groups":[{"description":"Luspatercept 1.0 mg/Kg SC on Day 1 of each 21-day treatment cycle","id":"OG000","title":"Luspatercept"},{"description":"Placebo (Volume equivalent to experimental arm) SC on Day 1 of each 21-day treatment cycle","id":"OG001","title":"Placebo"}],"paramType":"GEOMETRIC_MEAN","populationDescription":"Pharmacokinetic (PK) population included all participants who received at least 1 dose of luspatercept and had measurable luspatercept serum concentrations.","reportingStatus":"POSTED","timeFrame":"Blood serum samples taken pre-dose at Cycle 1 Day 1 (C1, D1), C1 D8, C1 D15, C2 D1, C4 D1, C5 D8, C6 D1 and Week 25 visit, extension phase C4 D1 and Day 1 of every fourth treatment cycle thereafter.","title":"Pharmacokinetic (PK) Parameters: Bayesian Estimate of Apparent Clearance (CL/F)","type":"SECONDARY","unitOfMeasure":"L/day"}