{"analyses":[{"ciLowerLimit":"0.56","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"0.94","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY","pValue":"0.0165","pValueComment":"A one-sided, log-rank test stratified for IMDC risk category and prior therapy (two VEGFR TKIs vs. a checkpoint inhibitor plus a VEGFR TKI vs. a VEGFR TKI plus any other systemic agent) at a significance level of α = 0.025 was used.","paramType":"Hazard Ratio (HR)","paramValue":"0.73","statisticalMethod":"Log Rank"}],"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"5.29","upperLimit":"7.33","value":"5.59"},{"groupId":"OG001","lowerLimit":"3.71","upperLimit":"5.55","value":"3.88"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"175"},{"groupId":"OG001","value":"175"}],"units":"Participants"}],"description":"The PFS, as assessed by a blinded independent radiological review (IRR), is defined as the time from randomization to first documentation of objective tumor progression (progressive disease) or death due to any reasons whichever comes first. Disease progression per RECIST 1.1 criteria is defined as a 20% increase in the sum of the longest diameter of target lesions, or a measurable increase in a non-target lesion, or the appearance of new lesions.","dispersionType":"95% Confidence Interval","groups":[{"description":"Participants randomized to this arm received the study drug, tivozanib hydrochloride.","id":"OG000","title":"Tivozanib Hydrochloride"},{"description":"Participants randomized to this arm received the comparator drug, sorafenib.","id":"OG001","title":"Sorafenib"}],"paramType":"MEDIAN","populationDescription":"Intent-to-treat (ITT) Population included all randomized participants.","reportingStatus":"POSTED","timeFrame":"From date of randomization until the date of first documented progression or date of death from any cause, whichever came first. Disease progression was assessed every 8 weeks (up to approximately 5 years)","title":"Progression-free Survival (PFS)","type":"PRIMARY","unitOfMeasure":"Months"}