{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"220"},{"groupId":"OG001","value":"81"}]}],"title":"TEAEs resulting in tuc/pbo dose modification"},{"categories":[{"measurements":[{"groupId":"OG000","value":"216"},{"groupId":"OG001","value":"80"}]}],"title":"TEAEs resulting in tucatinib/placebo dose hold"},{"categories":[{"measurements":[{"groupId":"OG000","value":"84"},{"groupId":"OG001","value":"21"}]}],"title":"TEAEs resulting in tuc/pbo dose reduction"},{"categories":[{"measurements":[{"groupId":"OG000","value":"313"},{"groupId":"OG001","value":"122"}]}],"title":"TEAEs resulting capecitabine dose modification"},{"categories":[{"measurements":[{"groupId":"OG000","value":"276"},{"groupId":"OG001","value":"113"}]}],"title":"TEAEs resulting in capecitabine dose hold"},{"categories":[{"measurements":[{"groupId":"OG000","value":"243"},{"groupId":"OG001","value":"77"}]}],"title":"TEAEs resulting in capecitabine dose reduction"},{"categories":[{"measurements":[{"groupId":"OG000","value":"104"},{"groupId":"OG001","value":"38"}]}],"title":"TEAEs resulting trastuzumab dose modification"},{"categories":[{"measurements":[{"groupId":"OG000","value":"104"},{"groupId":"OG001","value":"38"}]}],"title":"TEAEs resulting in trastuzumab dose hold"}],"denoms":[{"counts":[{"groupId":"OG000","value":"404"},{"groupId":"OG001","value":"197"}],"units":"Participants"}],"groups":[{"description":"Tucatinib in combination with capecitabine \\& trastuzumab","id":"OG000","title":"Tuc+Cap+Tra"},{"description":"Placebo in combination with capecitabine \\& trastuzumab","id":"OG001","title":"Pbo+Cap+Tra"}],"paramType":"COUNT_OF_PARTICIPANTS","populationDescription":"Safety Analysis Population: Includes all randomized participants who received at least one dose of study treatment (tucatinib/placebo, trastuzumab, or capecitabine), with participants allocated to the treatment group associated with the regimen actually received.","reportingStatus":"POSTED","timeFrame":"35.1 months","title":"Frequency of Dose Modifications","type":"SECONDARY","unitOfMeasure":"Participants"}