{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"1"}]}],"title":"Sitting Systolic Blood Pressure (mmHg) Change <=-40"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"2"}]}],"title":"Sitting Systolic Blood Pressure (mmHg) Change >-40 to -30"},{"categories":[{"measurements":[{"groupId":"OG000","value":"6"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"1"},{"groupId":"OG003","value":"3"}]}],"title":"Sitting Systolic Blood Pressure (mmHg) Change >-30 to -20"},{"categories":[{"measurements":[{"groupId":"OG000","value":"10"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"14"}]}],"title":"Sitting Systolic Blood Pressure (mmHg) Change >-20 to -10"},{"categories":[{"measurements":[{"groupId":"OG000","value":"26"},{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"25"}]}],"title":"Sitting Systolic Blood Pressure (mmHg) Change >-10 to 0"},{"categories":[{"measurements":[{"groupId":"OG000","value":"12"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"9"}]}],"title":"Sitting Systolic Blood Pressure (mmHg) Change >0 to <10"},{"categories":[{"measurements":[{"groupId":"OG000","value":"6"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"10"}]}],"title":"Sitting Systolic Blood Pressure (mmHg) Change >=10 to <20"},{"categories":[{"measurements":[{"groupId":"OG000","value":"5"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"3"}]}],"title":"Sitting Systolic Blood Pressure (mmHg) Change >=20 to <30"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"1"}]}],"title":"Sitting Systolic Blood Pressure (mmHg) Change >=30 to <40"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"1"}]}],"title":"Sitting Diastolic Blood Pressure (mmHg) Change >-30 to -20"},{"categories":[{"measurements":[{"groupId":"OG000","value":"10"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"1"},{"groupId":"OG003","value":"13"}]}],"title":"Sitting Diastolic Blood Pressure (mmHg) Change >-20 to -10"},{"categories":[{"measurements":[{"groupId":"OG000","value":"39"},{"groupId":"OG001","value":"4"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"26"}]}],"title":"Sitting Diastolic Blood Pressure (mmHg) Change >-10 to 0"},{"categories":[{"measurements":[{"groupId":"OG000","value":"11"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"18"}]}],"title":"Sitting Diastolic Blood Pressure (mmHg) Change >0 to <10"},{"categories":[{"measurements":[{"groupId":"OG000","value":"5"},{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"9"}]}],"title":"Sitting Diastolic Blood Pressure (mmHg) Change >=10 to <20"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"1"}]}],"title":"Sitting Diastolic Blood Pressure (mmHg) Change >=20 to <30"}],"denoms":[{"counts":[{"groupId":"OG000","value":"67"},{"groupId":"OG001","value":"9"},{"groupId":"OG002","value":"1"},{"groupId":"OG003","value":"68"}],"units":"Participants"}],"description":"Change categories for sitting systolic blood pressure measured in millimeter of mercury (mm Hg) were as follows: change \\<=-40, change \\>-40 to -30, change \\>-30 to -20, change \\>-20 to -10, change \\>-10 to 0, change \\>0 to \\<10, change \\>=10 to \\<20, change \\>=20 to \\<30, change \\>=30 to \\<40 and change \\>=40. Change categories for sitting diastolic blood pressure measured in mm Hg were as follow: change \\<=-30, change \\>-30 to -20, change \\>-20 to -10, change \\>-10 to 0, change \\>0 to \\<10, change \\>=10 to \\<20, change \\>=20 to \\<30 and change \\>=30. Rows with only non-zero data/values, for at least 1 reporting arm, are reported below.","groups":[{"description":"Participants received placebo matched to tanezumab SC once every 8 weeks for 24 weeks.","id":"OG000","title":"Placebo"},{"description":"Participants in this discontinued treatment arm, received tanezumab 10 mg SC once every 8 weeks before protocol amendment 3 and completed their treatment before the amendment.","id":"OG001","title":"Tanezumab 10 mg"},{"description":"Participants in this treatment group had received tanezumab 10 mg SC once every 8 weeks before protocol amendment 3 and after the amendment they continued remaining treatment with tanezumab 20 mg SC once every 8 weeks.","id":"OG002","title":"Tanezumab 10/20 mg"},{"description":"Participants received tanezumab 20 mg SC once every 8 weeks for 24 weeks.","id":"OG003","title":"Tanezumab 20 mg"}],"paramType":"COUNT_OF_PARTICIPANTS","populationDescription":"The safety analysis set was defined as all participants treated with tanezumab or placebo SC, including participants who received tanezumab 10 mg prior to protocol amendment 3. Here, \"Overall Number of Participants Analyzed\" signifies number of participants evaluable for this outcome measure.","reportingStatus":"POSTED","timeFrame":"Baseline (Day 1, before dosing) up to Week 24","title":"Number of Participants With Categorical Change From Baseline to Last Post-Baseline in Sitting Systolic and Diastolic Blood Pressure During Treatment Period","type":"SECONDARY","unitOfMeasure":"Participants"}