{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"390.54","value":"627.3"},{"groupId":"OG001","spread":"155.15","value":"224.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"173"},{"groupId":"OG001","value":"39"}],"units":"Participants"}],"title":"Number of participants analyzed for 33%"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"386.37","value":"491.1"},{"groupId":"OG001","spread":"142.51","value":"193.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"112"},{"groupId":"OG001","value":"9"}],"units":"Participants"}],"title":"Number of participants analyzed for 50%"}],"denoms":[{"counts":[{"groupId":"OG000","value":"173"},{"groupId":"OG001","value":"39"}],"units":"Participants"}],"description":"Responders were defined as subjects who achieved ≥ 33% reduction or ≥ 50% reduction in Red Blood Cells Transfusion (RBC-T) burden from baseline with a reduction of at least 2 RBC units during any rolling 12-week interval. The duration of reduction is calculated as Last Day of Response - First day of response +1","dispersionType":"Standard Deviation","groups":[{"description":"Luspatercept (ACE-536) was administered subcutaneously (SC) at a starting dose level of 1 mg/kg once every 21 days. Participants could be dose-titrated to 1.25 mg/kg, but the maximum total dose should not exceed 120 mg, total dose per administration during the Treatment Period, the Long-term Treatment Period, and Open-Label Treatment Period. BSC = Best Supportive Care","id":"OG000","title":"Luspatercept + BSC"},{"description":"Placebo (normal saline) was administered subcutaneously (SC) in volumes to match active treatment once every 21 days. BSC = Best Supportive Care","id":"OG001","title":"Placebo + BSC"}],"paramType":"MEAN","populationDescription":"All randomized participants with ≥ 33% reduction or ≥ 50% reduction in RBC-T burden","reportingStatus":"POSTED","timeFrame":"From first dose to end of study treatment (up to approximately 215 weeks)","title":"Duration of Reduction in Transfusion Burden","type":"SECONDARY","unitOfMeasure":"Days"}