{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"2.15","value":"0.2"},{"groupId":"OG001","spread":"2.25","value":"-0.4"},{"groupId":"OG002","spread":"3.14","value":"0.4"}]}],"title":"15 minutes"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"3.06","value":"-0.4"},{"groupId":"OG001","spread":"2.17","value":"0.5"},{"groupId":"OG002","spread":"2.91","value":"1.7"}]}],"title":"30 minutes"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"5.17","value":"-0.2"},{"groupId":"OG001","spread":"3.10","value":"0.4"},{"groupId":"OG002","spread":"3.51","value":"1.3"}]}],"title":"1 hour"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"1.76","value":"-0.7"},{"groupId":"OG001","spread":"5.00","value":"-0.3"},{"groupId":"OG002","spread":"2.36","value":"1.5"}]}],"title":"2 hour"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"4.64","value":"9.3"},{"groupId":"OG001","spread":"4.90","value":"9.0"},{"groupId":"OG002","spread":"4.01","value":"7.9"}]}],"title":"4 hour"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"6.71","value":"7.1"},{"groupId":"OG001","spread":"4.44","value":"4.6"},{"groupId":"OG002","spread":"3.59","value":"7.5"}]}],"title":"6 hour"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"6.29","value":"4.4"},{"groupId":"OG001","spread":"5.72","value":"4.4"},{"groupId":"OG002","spread":"5.61","value":"5.0"}]}],"title":"8 hour"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"3.58","value":"2.3"},{"groupId":"OG001","spread":"3.82","value":"3.8"},{"groupId":"OG002","spread":"4.01","value":"5.5"}]}],"title":"12 hour"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"3.93","value":"2.1"},{"groupId":"OG001","spread":"3.22","value":"2.1"},{"groupId":"OG002","spread":"3.15","value":"1.1"}]}],"title":"24 hour"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"5.53","value":"2.5"},{"groupId":"OG001","spread":"5.77","value":"4.9"},{"groupId":"OG002","spread":"9.99","value":"7.9"}]}],"title":"48 hour"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"7.06","value":"9.9"},{"groupId":"OG001","spread":"7.47","value":"9.8"},{"groupId":"OG002","spread":"8.94","value":"11.1"}]}],"title":"72 hour"}],"denoms":[{"counts":[{"groupId":"OG000","value":"8"},{"groupId":"OG001","value":"16"},{"groupId":"OG002","value":"8"}],"units":"Participants"}],"description":"Pulse rate was measured in semi-supine position after 5 minutes rest for the participants at indicated time points. Baseline is defined as the latest available assessment pre the first dose of study drug within each period in Part A. Change from Baseline was calculated as any visit post Baseline value minus Baseline value.","dispersionType":"Standard Deviation","groups":[{"description":"Participants received a single dose of GSK3039294 (dose level 1) 200 mg capsules, orally, once on Day 1 and stayed in-house until Day 4 in cohort 1.","id":"OG000","title":"Part A: GSK3039294 200 mg"},{"description":"Participants received a single dose of GSK3039294 (dose level 2) 600 mg capsules, orally, once on Day 1 and stayed in-house until Day 4 in cohort 1. The remaining participants received the same dose of GSK3039294 (dose level 3) 600 mg, capsules, orally, once on Day 1 and stayed in-house until Day 4 in cohort 2. A washout period was maintained from Day 5 to 14 between two treatment cohorts.","id":"OG001","title":"Part A: GSK3039294 600 mg"},{"description":"Participants received a single dose of GSK3039294 (dose level 4) 1200 mg, capsules, orally, once on Day 1 and stayed in-house until Day 4 in cohort 2.","id":"OG002","title":"Part A: GSK3039294 1200 mg"}],"paramType":"MEAN","populationDescription":"Safety population.","reportingStatus":"POSTED","timeFrame":"Baseline (pre-dose) and 15, 30 minutes, 1, 2, 4, 6, 8, 12, 24, 48 and 72 hours post-dose","title":"Part A: Mean Change From Baseline in Pulse Rate","type":"PRIMARY","unitOfMeasure":"Beats per minute"}