{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Albumin: low"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Albumin: high"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Calcium: low"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Calcium: high"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Glucose: low"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Glucose: high"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Potassium: low"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Potassium: high"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Sodium: low"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Sodium: high"}],"denoms":[{"counts":[{"groupId":"OG000","value":"8"},{"groupId":"OG001","value":"16"},{"groupId":"OG002","value":"8"}],"units":"Participants"}],"description":"PCI ranges for the clinical chemistry parameters were as follows : albumin (low: \\<0.86 gram \\[g\\] per liter \\[L\\]), calcium (low: \\<0.91 millimole \\[mmol\\]/L and high: \\>1.06 mmol/L), glucose (low: \\<0.71 mmol/L and high: \\>1.41 mmol/L), magnesium (low: \\<0.63 mmol/L and high: \\>1.03 mmol/L), phosphorous (low: \\<0.80 mmol/L and high: \\>1.14 mmol/L), potassium (low: \\<0.86 mmol/L and high: \\>1.10 mmol/L), sodium (low: \\<0.96 mmol/L and high: \\>1.03 mmol/L), and total carbon dioxide (CO2) (low: \\<0.86 mmol/L and high: \\>1.14 mmol/L).","groups":[{"description":"Participants received a single dose of GSK3039294 (dose level 1) 200 mg capsules, orally, once on Day 1 and stayed in-house until Day 4 in cohort 1.","id":"OG000","title":"Part A: GSK3039294 200 mg"},{"description":"Participants received a single dose of GSK3039294 (dose level 2) 600 mg capsules, orally, once on Day 1 and stayed in-house until Day 4 in cohort 1. The remaining participants received the same dose of GSK3039294 (dose level 3) 600 mg, capsules, orally, once on Day 1 and stayed in-house until Day 4 in cohort 2. A washout period was maintained from Day 5 to 14 between two treatment cohorts.","id":"OG001","title":"Part A: GSK3039294 600 mg"},{"description":"Participants received a single dose of GSK3039294 (dose level 4) 1200 mg, capsules, orally, once on Day 1 and stayed in-house until Day 4 in cohort 2.","id":"OG002","title":"Part A: GSK3039294 1200 mg"}],"paramType":"COUNT_OF_PARTICIPANTS","populationDescription":"Safety population.","reportingStatus":"POSTED","timeFrame":"Day 1","title":"Part A: Number of Participants With Emergent Clinical Chemistry by Potentially Clinical Importance (PCI) Criteria","type":"PRIMARY","unitOfMeasure":"Participants"}