{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"4"}],"title":"stringent complete response"},{"measurements":[{"groupId":"OG000","value":"3"}],"title":"complete response"},{"measurements":[{"groupId":"OG000","value":"32"}],"title":"very good partial response"},{"measurements":[{"groupId":"OG000","value":"21"}],"title":"partial response"},{"measurements":[{"groupId":"OG000","value":"1"}],"title":"minimal response"},{"measurements":[{"groupId":"OG000","value":"14"}],"title":"no response"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"75"}],"units":"Participants"}],"description":"Response rate to protocol treatment after 4 cycles is define by stringent complete response, complete response, partial response, very good partial response, minimal response.\n\nComplete response: Negative immunofixation on the serum and urine and Disappearance of any soft tissue plasmacytomas and \\< 5% plasma cells in bone marrow biopsy Stringent complete response: Complete response plus Absence of clonal cells in bone marrow d by immunohistochemistry or immunofluorescence Very good partial response: Serum and urine M-protein detectable by immunofixation but not on electrophoresis or ≥90% reduction in serum M-protein with urine M-protein level \\<100 mg/24 hours.\n\nPartial response: ≥50% reduction in serum M-protein and reduction in 24-hour urinary M-protein by ≥90% or to \\<200 mg/24 hours Minimal response: 25-49% reduction in serum M-protein, and 50-89% reduction in 24-hour urinary M-protein, if ≥ 200 mg/24 hours at baseline","groups":[{"description":"20 mg/m2 day 1 of first cycle then escalated to 70 mg/m2 for all subsequent doses) given on days 1, 8, and 15 of a 28 day cycle plus weekly oral dexamethasone (\\< 70 years, 40 mg; ≥ 70 years 20mg) and cyclophosphamide 300 mg/m2 capped at 500 mg\n\nCarfilzomib\n\nCyclophosphamide\n\nDexamethasone","id":"OG000","title":"Carfilzomib Plus Cyclophosphamide Plus Dexamethasone"}],"paramType":"COUNT_OF_PARTICIPANTS","populationDescription":"All eligible patients how have received treatment.","reportingStatus":"POSTED","timeFrame":"4 months","title":"Overall Response Rate After 4 Cycles","type":"PRIMARY","unitOfMeasure":"Participants"}