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Participants may also undergo biopsies during screening and on study.\n\nAntiretroviral Therapy: Given PO\n\nBiopsy: Undergo biopsy\n\nBiospecimen Collection: Undergo blood sample collection\n\nComputed Tomography: Undergo CT or PET/CT\n\nPembrolizumab: Given IV\n\nPositron Emission Tomography: Undergo PET/CT","id":"EG000","otherNumAffected":10,"otherNumAtRisk":10,"seriousNumAffected":8,"seriousNumAtRisk":10,"title":"Cohort 1 (Pembrolizumab and cART)"},{"deathsNumAffected":5,"deathsNumAtRisk":12,"description":"Participants enrolled into Cohort 2 (200-350 CD4+ cells/mcL), who receive pembrolizumab IV over 30 minutes on day 1. Participants continue receiving their recommended combination antiretroviral therapy per established regimen. Cycles repeat every 21 days for up to 2 years or 35 doses in the absence of disease progression or unacceptable toxicity. Participants also undergo CT or PET/CT and blood sample collection throughout the trial. Participants may also undergo biopsies during screening and on study.\n\nAntiretroviral Therapy: Given PO\n\nBiopsy: Undergo biopsy\n\nBiospecimen Collection: Undergo blood sample collection\n\nComputed Tomography: Undergo CT or PET/CT\n\nPembrolizumab: Given IV\n\nPositron Emission Tomography: Undergo PET/CT","id":"EG001","otherNumAffected":12,"otherNumAtRisk":12,"seriousNumAffected":8,"seriousNumAtRisk":12,"title":"Cohort 2 (Pembrolizumab and cART)"},{"deathsNumAffected":5,"deathsNumAtRisk":12,"description":"Participants enrolled into Cohort 3 (\\> 350 CD4+ cells/mcl), who receive pembrolizumab IV over 30 minutes on day 1. Participants continue receiving their recommended combination antiretroviral therapy per established regimen. Cycles repeat every 21 days for up to 2 years or 35 doses in the absence of disease progression or unacceptable toxicity. Participants also undergo CT or PET/CT and blood sample collection throughout the trial. Participants may also undergo biopsies during screening and on study.\n\nAntiretroviral Therapy: Given PO\n\nBiopsy: Undergo biopsy\n\nBiospecimen Collection: Undergo blood sample collection\n\nComputed Tomography: Undergo CT or PET/CT\n\nPembrolizumab: Given IV\n\nPositron Emission Tomography: Undergo PET/CT","id":"EG002","otherNumAffected":12,"otherNumAtRisk":12,"seriousNumAffected":6,"seriousNumAtRisk":12,"title":"Cohort 3 (Pembrolizumab and cART)"},{"deathsNumAffected":2,"deathsNumAtRisk":24,"description":"Participants with HIV associated Kaposi sarcoma enrolled into cohort 4, who receive pembrolizumab IV over 30 minutes on day 1. Participants continue receiving their recommended combination antiretroviral therapy per established regimen. Cycles repeat every 21 days for up to 2 years or 35 doses in the absence of disease progression or unacceptable toxicity. Participants undergo physical examination and blood sample collection, and may undergo CT or PET/CT. Participants may also undergo biopsies during screening and on study.\n\nAntiretroviral Therapy: Given PO\n\nBiopsy: Undergo biopsy\n\nBiospecimen Collection: Undergo blood sample collection\n\nComputed Tomography: Undergo CT or PET/CT\n\nPembrolizumab: Given IV\n\nPositron Emission Tomography: Undergo PET/CT","id":"EG003","otherNumAffected":24,"otherNumAtRisk":24,"seriousNumAffected":9,"seriousNumAtRisk":24,"title":"Cohort 4 (Pembrolizumab and cART)"},{"deathsNumAffected":17,"deathsNumAtRisk":58,"description":"Participants enrolled into Cohorts 1-4, who receive pembrolizumab IV over 30 minutes on day 1. Participants continue receiving their recommended combination antiretroviral therapy per established regimen. Cycles repeat every 21 days for up to 2 years or 35 doses in the absence of disease progression or unacceptable toxicity. Participants also undergo physical examination, CT or PET/CT, and blood sample collection throughout the trial. Participants may also undergo biopsies during screening and on study.\n\nAntiretroviral Therapy: Given PO\n\nBiopsy: Undergo biopsy\n\nBiospecimen Collection: Undergo blood sample collection\n\nComputed Tomography: Undergo CT or PET/CT\n\nPembrolizumab: Given IV\n\nPositron Emission Tomography: Undergo PET/CT","id":"EG004","otherNumAffected":58,"otherNumAtRisk":58,"seriousNumAffected":31,"seriousNumAtRisk":58,"title":"Total"}],"frequencyThreshold":"5","otherEvents":[{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"MedDRA (12.0)","stats":[{"groupId":"EG000","numAffected":5,"numAtRisk":10},{"groupId":"EG001","numAffected":10,"numAtRisk":12},{"groupId":"EG002","numAffected":7,"numAtRisk":12},{"groupId":"EG003","numAffected":11,"numAtRisk":24},{"groupId":"EG004","numAffected":33,"numAtRisk":58}],"term":"Anemia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Cardiac disorders","sourceVocabulary":"MedDRA 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(12.0)","stats":[{"groupId":"EG000","numAffected":4,"numAtRisk":10},{"groupId":"EG001","numAffected":4,"numAtRisk":12},{"groupId":"EG002","numAffected":1,"numAtRisk":12},{"groupId":"EG003","numAffected":2,"numAtRisk":24},{"groupId":"EG004","numAffected":11,"numAtRisk":58}],"term":"Abdominal pain"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA (12.0)","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":10},{"groupId":"EG001","numAffected":0,"numAtRisk":12},{"groupId":"EG002","numAffected":0,"numAtRisk":12},{"groupId":"EG003","numAffected":4,"numAtRisk":24},{"groupId":"EG004","numAffected":7,"numAtRisk":58}],"term":"Bloating"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA (12.0)","stats":[{"groupId":"EG000","numAffected":5,"numAtRisk":10},{"groupId":"EG001","numAffected":3,"numAtRisk":12},{"groupId":"EG002","numAffected":4,"numAtRisk":12},{"groupId":"EG003","numAffected":5,"numAtRisk":24},{"groupId":"EG004","numAffected":17,"numAtRisk":58}],"term":"Constipation"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA (12.0)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10},{"groupId":"EG001","numAffected":1,"numAtRisk":12},{"groupId":"EG002","numAffected":3,"numAtRisk":12},{"groupId":"EG003","numAffected":3,"numAtRisk":24},{"groupId":"EG004","numAffected":8,"numAtRisk":58}],"term":"Diarrhea"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA 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(12.0)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10},{"groupId":"EG001","numAffected":1,"numAtRisk":12},{"groupId":"EG002","numAffected":1,"numAtRisk":12},{"groupId":"EG003","numAffected":0,"numAtRisk":24},{"groupId":"EG004","numAffected":3,"numAtRisk":58}],"term":"Chills"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"MedDRA (12.0)","stats":[{"groupId":"EG000","numAffected":5,"numAtRisk":10},{"groupId":"EG001","numAffected":1,"numAtRisk":12},{"groupId":"EG002","numAffected":0,"numAtRisk":12},{"groupId":"EG003","numAffected":2,"numAtRisk":24},{"groupId":"EG004","numAffected":8,"numAtRisk":58}],"term":"Edema limbs"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"General disorders","sourceVocabulary":"MedDRA (12.0)","stats":[{"groupId":"EG000","numAffected":6,"numAtRisk":10},{"groupId":"EG001","numAffected":9,"numAtRisk":12},{"groupId":"EG002","numAffected":6,"numAtRisk":12},{"groupId":"EG003","numAffected":9,"numAtRisk":24},{"groupId":"EG004","numAffected":30,"numAtRisk":58}],"term":"Fatigue"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"General disorders","sourceVocabulary":"MedDRA (12.0)","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":10},{"groupId":"EG001","numAffected":2,"numAtRisk":12},{"groupId":"EG002","numAffected":1,"numAtRisk":12},{"groupId":"EG003","numAffected":3,"numAtRisk":24},{"groupId":"EG004","numAffected":8,"numAtRisk":58}],"term":"Fever"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"General disorders","sourceVocabulary":"MedDRA (12.0)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":10},{"groupId":"EG001","numAffected":1,"numAtRisk":12},{"groupId":"EG002","numAffected":1,"numAtRisk":12},{"groupId":"EG003","numAffected":2,"numAtRisk":24},{"groupId":"EG004","numAffected":4,"numAtRisk":58}],"term":"Night sweats"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"General disorders","sourceVocabulary":"MedDRA (12.0)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10},{"groupId":"EG001","numAffected":1,"numAtRisk":12},{"groupId":"EG002","numAffected":1,"numAtRisk":12},{"groupId":"EG003","numAffected":1,"numAtRisk":24},{"groupId":"EG004","numAffected":4,"numAtRisk":58}],"term":"Non-cardiac chest pain"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"General disorders","sourceVocabulary":"MedDRA (12.0)","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":10},{"groupId":"EG001","numAffected":2,"numAtRisk":12},{"groupId":"EG002","numAffected":1,"numAtRisk":12},{"groupId":"EG003","numAffected":5,"numAtRisk":24},{"groupId":"EG004","numAffected":13,"numAtRisk":58}],"term":"Pain"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"MedDRA (12.0)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":10},{"groupId":"EG001","numAffected":4,"numAtRisk":12},{"groupId":"EG002","numAffected":0,"numAtRisk":12},{"groupId":"EG003","numAffected":1,"numAtRisk":24},{"groupId":"EG004","numAffected":5,"numAtRisk":58}],"term":"Upper respiratory infection"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"MedDRA (12.0)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10},{"groupId":"EG001","numAffected":1,"numAtRisk":12},{"groupId":"EG002","numAffected":0,"numAtRisk":12},{"groupId":"EG003","numAffected":1,"numAtRisk":24},{"groupId":"EG004","numAffected":3,"numAtRisk":58}],"term":"Urinary tract infection"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"MedDRA (12.0)","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":10},{"groupId":"EG001","numAffected":4,"numAtRisk":12},{"groupId":"EG002","numAffected":4,"numAtRisk":12},{"groupId":"EG003","numAffected":4,"numAtRisk":24},{"groupId":"EG004","numAffected":14,"numAtRisk":58}],"term":"Alanine aminotransferase increased"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"MedDRA (12.0)","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":10},{"groupId":"EG001","numAffected":6,"numAtRisk":12},{"groupId":"EG002","numAffected":5,"numAtRisk":12},{"groupId":"EG003","numAffected":0,"numAtRisk":24},{"groupId":"EG004","numAffected":13,"numAtRisk":58}],"term":"Alkaline phosphatase increased"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"MedDRA (12.0)","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":10},{"groupId":"EG001","numAffected":4,"numAtRisk":12},{"groupId":"EG002","numAffected":4,"numAtRisk":12},{"groupId":"EG003","numAffected":7,"numAtRisk":24},{"groupId":"EG004","numAffected":18,"numAtRisk":58}],"term":"Aspartate aminotransferase increased"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"MedDRA (12.0)","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":10},{"groupId":"EG001","numAffected":2,"numAtRisk":12},{"groupId":"EG002","numAffected":1,"numAtRisk":12},{"groupId":"EG003","numAffected":4,"numAtRisk":24},{"groupId":"EG004","numAffected":9,"numAtRisk":58}],"term":"Blood bilirubin increased"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"MedDRA (12.0)","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":10},{"groupId":"EG001","numAffected":6,"numAtRisk":12},{"groupId":"EG002","numAffected":3,"numAtRisk":12},{"groupId":"EG003","numAffected":5,"numAtRisk":24},{"groupId":"EG004","numAffected":17,"numAtRisk":58}],"term":"CD4 lymphocytes decreased"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"MedDRA 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(12.0)","stats":[{"groupId":"EG000","numAffected":6,"numAtRisk":10},{"groupId":"EG001","numAffected":9,"numAtRisk":12},{"groupId":"EG002","numAffected":3,"numAtRisk":12},{"groupId":"EG003","numAffected":10,"numAtRisk":24},{"groupId":"EG004","numAffected":28,"numAtRisk":58}],"term":"Lymphocyte count decreased"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"MedDRA (12.0)","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":10},{"groupId":"EG001","numAffected":4,"numAtRisk":12},{"groupId":"EG002","numAffected":0,"numAtRisk":12},{"groupId":"EG003","numAffected":6,"numAtRisk":24},{"groupId":"EG004","numAffected":12,"numAtRisk":58}],"term":"Neutrophil count decreased"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"MedDRA 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