{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0.0","upperLimit":"0.0","value":"0.00"},{"groupId":"OG001","lowerLimit":"0.0","upperLimit":"0.1","value":"0.00"},{"groupId":"OG002","lowerLimit":"0.0","upperLimit":"4.0","value":"0.56"},{"groupId":"OG003","lowerLimit":"0.0","upperLimit":"0.6","value":"0.02"},{"groupId":"OG004","lowerLimit":"0.0","upperLimit":"3.0","value":"0.32"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"8"},{"groupId":"OG002","value":"7"},{"groupId":"OG003","value":"6"},{"groupId":"OG004","value":"13"}],"units":"Participants"}],"title":"Cycle 1 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0.0","upperLimit":"0.0","value":"0.00"},{"groupId":"OG001","lowerLimit":"0.0","upperLimit":"0.0","value":"0.00"},{"groupId":"OG002","lowerLimit":"0.0","upperLimit":"0.2","value":"0.00"},{"groupId":"OG003","lowerLimit":"0.0","upperLimit":"1.4","value":"0.00"},{"groupId":"OG004","lowerLimit":"0.0","upperLimit":"3.1","value":"0.00"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"6"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"7"},{"groupId":"OG004","value":"15"}],"units":"Participants"}],"title":"Cycle 1 Day 8"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0.0","upperLimit":"0.0","value":"0.00"},{"groupId":"OG001","lowerLimit":"0.0","upperLimit":"1.3","value":"0.00"},{"groupId":"OG002","lowerLimit":"0.0","upperLimit":"0.6","value":"0.00"},{"groupId":"OG003","lowerLimit":"0.0","upperLimit":"7.7","value":"0.00"},{"groupId":"OG004","lowerLimit":"0.0","upperLimit":"4.5","value":"0.57"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"6"},{"groupId":"OG002","value":"7"},{"groupId":"OG003","value":"7"},{"groupId":"OG004","value":"12"}],"units":"Participants"}],"title":"Cycle 1 Day 15"},{"categories":[{"measurements":[{"groupId":"OG004","lowerLimit":"0.0","upperLimit":"1.0","value":"0.00"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"},{"groupId":"OG004","value":"13"}],"units":"Participants"}],"title":"Cycle 1 Day 21"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0.0","upperLimit":"3.0","value":"1.48"},{"groupId":"OG001","lowerLimit":"0.0","upperLimit":"1.7","value":"0.04"},{"groupId":"OG002","lowerLimit":"0.0","upperLimit":"3.0","value":"0.82"},{"groupId":"OG003","lowerLimit":"0.0","upperLimit":"1.0","value":"0.00"},{"groupId":"OG004","lowerLimit":"0.0","upperLimit":"4.7","value":"0.00"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"6"},{"groupId":"OG002","value":"5"},{"groupId":"OG003","value":"5"},{"groupId":"OG004","value":"14"}],"units":"Participants"}],"title":"Cycle 2 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0.0","upperLimit":"0.0","value":"0.00"},{"groupId":"OG001","lowerLimit":"0.0","upperLimit":"0.2","value":"0.00"},{"groupId":"OG002","lowerLimit":"0.0","upperLimit":"3.1","value":"0.47"},{"groupId":"OG003","lowerLimit":"0.0","upperLimit":"2.3","value":"0.00"},{"groupId":"OG004","lowerLimit":"0.0","upperLimit":"4.7","value":"0.00"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"4"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"5"},{"groupId":"OG004","value":"11"}],"units":"Participants"}],"title":"Cycle 3 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0.5","upperLimit":"1.1","value":"0.80"},{"groupId":"OG001","lowerLimit":"0.0","upperLimit":"0.0","value":"0.00"},{"groupId":"OG002","lowerLimit":"0.0","upperLimit":"23.2","value":"0.05"},{"groupId":"OG003","lowerLimit":"0.0","upperLimit":"2.1","value":"0.00"},{"groupId":"OG004","lowerLimit":"0.0","upperLimit":"2.1","value":"0.00"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"8"},{"groupId":"OG002","value":"5"},{"groupId":"OG003","value":"6"},{"groupId":"OG004","value":"7"}],"units":"Participants"}],"title":"Cycle 4 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0.0","upperLimit":"0.0","value":"0.00"},{"groupId":"OG001","lowerLimit":"0.0","upperLimit":"2.6","value":"0.00"},{"groupId":"OG002","lowerLimit":"0.0","upperLimit":"0.0","value":"0.00"},{"groupId":"OG003","lowerLimit":"0.0","upperLimit":"0.7","value":"0.00"},{"groupId":"OG004","lowerLimit":"0.0","upperLimit":"1.4","value":"0.00"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"2"},{"groupId":"OG003","value":"7"},{"groupId":"OG004","value":"6"}],"units":"Participants"}],"title":"Cycle 4 Day 15"},{"categories":[{"measurements":[{"groupId":"OG004","lowerLimit":"0.0","upperLimit":"1.4","value":"1.31"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"},{"groupId":"OG004","value":"5"}],"units":"Participants"}],"title":"Cycle 4 Day 21"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0.0","upperLimit":"0.0","value":"0.00"},{"groupId":"OG001","lowerLimit":"0.0","upperLimit":"0.0","value":"0.00"},{"groupId":"OG002","lowerLimit":"0.0","upperLimit":"3.2","value":"0.00"},{"groupId":"OG003","lowerLimit":"0.0","upperLimit":"1.2","value":"0.00"},{"groupId":"OG004","lowerLimit":"0.0","upperLimit":"1.5","value":"0.00"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"4"},{"groupId":"OG002","value":"5"},{"groupId":"OG003","value":"5"},{"groupId":"OG004","value":"15"}],"units":"Participants"}],"title":"Cycle 5 Day 1"},{"categories":[{"measurements":[{"groupId":"OG001","lowerLimit":"0.0","upperLimit":"0.5","value":"0.00"},{"groupId":"OG002","lowerLimit":"0.0","upperLimit":"0.7","value":"0.00"},{"groupId":"OG003","lowerLimit":"0.0","upperLimit":"0.5","value":"0.00"},{"groupId":"OG004","lowerLimit":"0.0","upperLimit":"2.7","value":"0.17"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"6"},{"groupId":"OG002","value":"4"},{"groupId":"OG003","value":"4"},{"groupId":"OG004","value":"10"}],"units":"Participants"}],"title":"EOT"}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"8"},{"groupId":"OG002","value":"7"},{"groupId":"OG003","value":"7"},{"groupId":"OG004","value":"15"}],"units":"Participants"}],"description":"PD-1 RO by sasanlimab was measured by the reduction of free receptor on the surface of CD8+ effector cells (CD3+, CD4-, CD8+, CD45RA+, CCR7-, CD279+) and CD8+ effector memory cells (CD3+, CD4-, CD8+, CD45RA-, CCR7-, CD279+) presented in pre- and postdose whole blood samples by flow cytometry. Percentage of baseline (ie, normalized change from baseline) PD-1 RO were calculated as \\[(percentage of cells at Cycle X Day X)/(percentage of cells at baseline)\\]\\*100, and are reported for this outcome measure. Baseline was defined as the most recent non-missing value prior to dosing.","dispersionType":"Full Range","groups":[{"description":"Participants received PF-06801591 0.5 mg/kg IV every 3 weeks for 21-day cycles. (maximum of 1186 days)","id":"OG000","title":"Part 1: PF-06801591 0.5 mg/kg (Intravenously [IV])"},{"description":"Participants received PF-06801591 1 mg/kg IV every 3 weeks for 21-day cycles. (maximum of 659 days)","id":"OG001","title":"Part 1: PF-06801591 1 mg/kg (IV)"},{"description":"Participants received PF-06801591 3 mg/kg IV every 3 weeks for 21-day cycles. (maximum of 1606 days)","id":"OG002","title":"Part 1: PF-06801591 3 mg/kg (IV)"},{"description":"Participants received PF-06801591 10 mg/kg IV every 3 weeks for 21-day cycles. (maximum of 445 days)","id":"OG003","title":"Part 1: PF-06801591 10 mg/kg (IV)"},{"description":"Participants received PF-06801591 300 mg SC every 4 weeks for 28-day cycles. (maximum of 419 days)","id":"OG004","title":"Part 1: PF-06801591 300 mg (Subcutaneously [SC])"}],"paramType":"MEDIAN","populationDescription":"Analysis population included all enrolled participants with at least 1 of the pharmacodynamic/biomarker parameters evaluated at pre- and/or post dose.","reportingStatus":"POSTED","timeFrame":"Baseline, Days 1, 8, 15, 21 of Cycle 1, Day 1 of Cycles 2, 3, 5, Days 1, 15, 21 of Cycle 4, and end of treatment (EOT) in Part 1 (cycle = 21 days for IV dosing; cycle = 28 days for SC dosing)","title":"Percentage of Baseline PD-1 Receptor Occupancy (RO) by PF-06801591 - Part 1","type":"SECONDARY","unitOfMeasure":"Percentage of Baseline"}