{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1.62","upperLimit":"1.98","value":"1.95"},{"groupId":"OG001","lowerLimit":"1.87","upperLimit":"4.08","value":"4.03"},{"groupId":"OG002","lowerLimit":"1.95","upperLimit":"6.88","value":"4.12"},{"groupId":"OG003","lowerLimit":"1.87","upperLimit":"2.07","value":"2.02"},{"groupId":"OG004","lowerLimit":"1.50","upperLimit":"3.97","value":"2.06"},{"groupId":"OG005","lowerLimit":"1.70","upperLimit":"6.80","value":"1.97"},{"groupId":"OG006","lowerLimit":"1.50","upperLimit":"6.85","value":"2.00"},{"groupId":"OG007","lowerLimit":"1.53","upperLimit":"7.05","value":"2.08"},{"groupId":"OG008","lowerLimit":"1.50","upperLimit":"7.07","value":"2.16"},{"groupId":"OG009","lowerLimit":"1.50","upperLimit":"6.67","value":"2.00"},{"groupId":"OG010","lowerLimit":"1.58","upperLimit":"4.08","value":"2.03"},{"groupId":"OG011","lowerLimit":"1.53","upperLimit":"7.00","value":"1.95"},{"groupId":"OG012","lowerLimit":"1.50","upperLimit":"7.20","value":"2.02"},{"groupId":"OG013","lowerLimit":"1.62","upperLimit":"7.23","value":"2.05"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"3"},{"groupId":"OG003","value":"6"},{"groupId":"OG004","value":"6"},{"groupId":"OG005","value":"5"},{"groupId":"OG006","value":"48"},{"groupId":"OG007","value":"50"},{"groupId":"OG008","value":"20"},{"groupId":"OG009","value":"19"},{"groupId":"OG010","value":"17"},{"groupId":"OG011","value":"23"},{"groupId":"OG012","value":"59"},{"groupId":"OG013","value":"21"}],"units":"Participants"}],"description":"The serum PK parameters of Time of maximum plasma concentration (Tmax) for DS-8201a and its analytes were estimated using standard non-compartmental methods.","dispersionType":"Full Range","groups":[{"description":"Participants in Cohort 1 received an intravenous 0.8 mg/kg dose of DS-8201a (FL-DP1).","id":"OG000","title":"Dose Escalation: Cohort 1, 0.8 mg/kg"},{"description":"Participants in Cohort 2 received an intravenous 1.6 mg/kg dose of DS-8201a (FL-DP1).","id":"OG001","title":"Dose Escalation: Cohort 2, 1.6 mg/kg"},{"description":"Participants in Cohort 3 received an intravenous 3.2 mg/kg dose of DS-8201a (FL-DP1).","id":"OG002","title":"Dose Escalation: Cohort 3, 3.2 mg/kg"},{"description":"Participants in Cohort 4 received an intravenous 5.4 mg/kg dose of DS-8201a (FL-DP1).","id":"OG003","title":"Dose Escalation: Cohort 4, 5.4 mg/kg"},{"description":"Participants in Cohort 5 received an intravenous 6.4 mg/kg dose of DS-8201a (FL-DP1).","id":"OG004","title":"Dose Escalation: Cohort 5, 6.4 mg/kg"},{"description":"Participants in Cohort 6 received an intravenous 8.0 mg/kg dose of DS-8201a (FL-DP1).","id":"OG005","title":"Dose Escalation: Cohort 6, 8.0 mg/kg"},{"description":"Participants with HER2-overexpressing breast cancer received an intravenous 5.4 mg/kg dose of DS-8201a (FL-DP1).","id":"OG006","title":"Dose Expansion: HER2-positive Breast Cancer, 5.4 mg/kg"},{"description":"Participants with HER2-overexpressing breast cancer received an intravenous 6.4 mg/kg dose of DS-8201a (FL-DP1).","id":"OG007","title":"Dose Expansion: HER2-positive Breast Cancer, 6.4 mg/kg"},{"description":"Participants with HER2-low expressing breast cancer received an intravenous 5.4 mg/kg dose of DS-8201a (FL-DP1).","id":"OG008","title":"Dose Expansion: HER2-low Expressing Breast Cancer, 5.4 mg/kg"},{"description":"Participants with HER2-low expressing breast cancer received an intravenous 6.4 mg/kg dose of DS-8201a (FL-DP1).","id":"OG009","title":"Dose Expansion: HER2-low Expressing Breast Cancer, 6.4 mg/kg"},{"description":"Participants with HER2-overexpressing gastric or gastroesophageal junction (GEJ) adenocarcinoma received an intravenous 6.4 mg/kg dose of DS-8201a (FL-DP1).","id":"OG010","title":"Dose Expansion: HER2-overexpressing Gastric or GEJ, 5.4 mg/kg"},{"description":"Participants with HER2-overexpressing gastric or gastroesophageal junction (GEJ) adenocarcinoma received an intravenous 6.4 mg/kg dose of DS-8201a (FL-DP1).","id":"OG011","title":"Dose Expansion: HER2-overexpressing Gastric or GEJ, 6.4 mg/kg"},{"description":"Participants with any other HER2-expressing solid tumor other than breast or gastric or any tumor with HER2 mutation received an intravenous 6.4 mg/kg dose of DS-8201a (FL-DP1).","id":"OG012","title":"Dose Expansion: HER2-expressing Other Solid Tumors"},{"description":"Japan only: Participants with HER2-expressing breast cancer received an intravenous 6.4 mg/kg dose of DS-8201a (FL-DP2).","id":"OG013","title":"Dose Expansion: HER2-expressing Breast Cancer"}],"paramType":"MEDIAN","populationDescription":"Pharmacokinetic parameters were assessed in the Pharmacokinetic Analysis Set.","reportingStatus":"POSTED","timeFrame":"Post first dose up to Day 147","title":"Pharmacokinetic Analysis: Time of Maximum Plasma Concentration (Tmax) of Serum DS-8201a Following First Dose","type":"SECONDARY","unitOfMeasure":"hours"}