{"classes":[{"categories":[{"measurements":[{"comment":"week 0 pre-dose serum concentrations are below the level of detection","groupId":"OG000","spread":"NA","value":"NA"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"332"}],"units":"Participants"}],"title":"Week 0 - Predose"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"11.5","value":"24.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"332"}],"units":"Participants"}],"title":"Week 0 - Postdose"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"3.18","value":"3.75"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"283"}],"units":"Participants"}],"title":"Week 4 - Predose"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"4.01","value":"5.43"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"197"}],"units":"Participants"}],"title":"Week 12 - Predose"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"13.2","value":"28.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"182"}],"units":"Participants"}],"title":"Week 12 - Postdose"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"1.40","value":"0.943"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"63"}],"units":"Participants"}],"title":"Follow-up Month 3"}],"denoms":[{"counts":[{"groupId":"OG000","value":"339"}],"units":"Participants"}],"description":"Blood samples were collected to determine the serum concentration of tremelimumab.","dispersionType":"Standard Deviation","groups":[{"description":"MEDI4736 (Durvalumab) + Tremelimumab","id":"OG000","title":"Combination Therapy"}],"paramType":"MEAN","populationDescription":"Pharmacokinetic analysis set included all patients who received at least 1 dose of durvalumab or tremelimumab per the protocol and had at least one post dose evaluable PK data of durvalumab or tremelimumab","reportingStatus":"POSTED","timeFrame":"Pre-dose and within 1 hour after end of infusion at Week 0, 12 and 24, pre-dose at week 4, and at follow-up Month 3.","title":"Serum Concentrations of Tremelimumab, Pharmacokinetic Analysis Set","type":"SECONDARY","unitOfMeasure":"μg/mL"}