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Patients received placebo administered IV once daily on Days 1 to 5 of each 21-day topotecan chemotherapy cycle.\n\nFollowing administration of placebo on Days 1 to 5, patients received IV topotecan (1.5 mg/m²).\n\nPlacebos\n\nTopotecan","id":"EG000","otherNumAffected":27,"otherNumAtRisk":28,"seriousNumAffected":7,"seriousNumAtRisk":28,"title":"Placebo + Topotecan 1.5 mg/m² - Parts 2a and 2b"},{"deathsNumAffected":28,"deathsNumAtRisk":30,"description":"Patients in Part 2a were randomized 2:1 to trilaciclib. Patients received trilaciclib (240 mg/m²) administered IV once daily on Days 1 to 5 of each 21-day topotecan chemotherapy cycle.\n\nFollowing administration of trilaciclib on Days 1 to 5, patients received IV topotecan (0.75 mg/m²).\n\nTrilaciclib\n\nTopotecan","id":"EG001","otherNumAffected":29,"otherNumAtRisk":30,"seriousNumAffected":15,"seriousNumAtRisk":30,"title":"Trilaciclib (G1T28) 240 mg/m² + Topotecan 0.75 mg/m² - Part 2a"},{"deathsNumAffected":29,"deathsNumAtRisk":32,"description":"Patients in Part 2b were randomized 2:1 to trilaciclib. Patients received trilaciclib (240 mg/m²) administered IV once daily on Days 1 to 5 of each 21-day topotecan chemotherapy cycle.\n\nFollowing administration of trilaciclib on Days 1 to 5, patients received IV topotecan (1.5 mg/m²).\n\nTrilaciclib\n\nTopotecan","id":"EG002","otherNumAffected":32,"otherNumAtRisk":32,"seriousNumAffected":12,"seriousNumAtRisk":32,"title":"Trilaciclib (G1T28) 240 mg/m² + Topotecan 1.5 mg/m² - Part 2b"},{"deathsNumAffected":0,"deathsNumAtRisk":2,"description":"Patients received trilaciclib (200 mg/m²) administered intravenously (IV) once daily on Days 1 to 5 of each 21-day topotecan chemotherapy cycle.\n\nFollowing administration of trilaciclib on Days 1 to 5, patients received IV topotecan (1.50 mg/m²).","id":"EG003","otherNumAffected":2,"otherNumAtRisk":2,"seriousNumAffected":2,"seriousNumAtRisk":2,"title":"Trilaciclib (G1T28) 200 mg/m² + Topotecan 1.5 mg/m² - Cohort 1- Part 1"},{"deathsNumAffected":3,"deathsNumAtRisk":3,"description":"Patients received trilaciclib (200 mg/m²) administered intravenously (IV) once daily on Days 1 to 5 of each 21-day topotecan chemotherapy cycle.\n\nFollowing administration of trilaciclib on Days 1 to 5, patients received IV topotecan (1.25 mg/m²).","id":"EG004","otherNumAffected":3,"otherNumAtRisk":3,"seriousNumAffected":1,"seriousNumAtRisk":3,"title":"Trilaciclib (G1T28) 200 mg/m² + Topotecan 1.25 mg/m² - Cohort 2- Part 1"},{"deathsNumAffected":4,"deathsNumAtRisk":4,"description":"Patients received trilaciclib (200 mg/m²) administered intravenously (IV) once daily on Days 1 to 5 of each 21-day topotecan chemotherapy cycle.\n\nFollowing administration of trilaciclib on Days 1 to 5, patients received IV topotecan (0.75 mg/m²).","id":"EG005","otherNumAffected":4,"otherNumAtRisk":4,"seriousNumAffected":2,"seriousNumAtRisk":4,"title":"Trilaciclib (G1T28) 200 mg/m² + Topotecan 0.75 mg/m² - Cohort 3- Part 1"},{"deathsNumAffected":8,"deathsNumAtRisk":8,"description":"Patients received trilaciclib (240 mg/m²) administered intravenously (IV) once daily on Days 1 to 5 of each 21-day topotecan chemotherapy cycle.\n\nFollowing administration of trilaciclib on Days 1 to 5, patients received IV topotecan (0.75 mg/m²).","id":"EG006","otherNumAffected":8,"otherNumAtRisk":8,"seriousNumAffected":0,"seriousNumAtRisk":8,"title":"Trilaciclib (G1T28) 240 mg/m² + Topotecan 0.75 mg/m² - Cohorts 4 and 6- Part 1"},{"deathsNumAffected":6,"deathsNumAtRisk":7,"description":"Patients received trilaciclib (280 mg/m²) administered intravenously (IV) once daily on Days 1 to 5 of each 21-day topotecan chemotherapy cycle.\n\nFollowing administration of trilaciclib on Days 1 to 5, patients received IV topotecan (0.75 mg/m²).","id":"EG007","otherNumAffected":7,"otherNumAtRisk":7,"seriousNumAffected":1,"seriousNumAtRisk":7,"title":"Trilaciclib (G1T28) 280 mg/m² + Topotecan 0.75 mg/m² - Cohort 5- Part 1"},{"deathsNumAffected":5,"deathsNumAtRisk":8,"description":"Patients received trilaciclib (240 mg/m²) administered intravenously (IV) once daily on Days 1 to 5 of each 21-day topotecan chemotherapy cycle.\n\nFollowing administration of trilaciclib on Days 1 to 5, patients received IV topotecan (1.0 mg/m²).","id":"EG008","otherNumAffected":8,"otherNumAtRisk":8,"seriousNumAffected":1,"seriousNumAtRisk":8,"title":"Trilaciclib (G1T28) 240 mg/m² + Topotecan 1.0 mg/m² - Cohort 7- Part 1"}],"frequencyThreshold":"5","otherEvents":[{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"MedDRA 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(20.1)","stats":[{"groupId":"EG000","numAffected":14,"numAtRisk":28,"numEvents":21},{"groupId":"EG001","numAffected":16,"numAtRisk":30,"numEvents":20},{"groupId":"EG002","numAffected":9,"numAtRisk":32,"numEvents":18},{"groupId":"EG003","numAffected":0,"numAtRisk":2},{"groupId":"EG004","numAffected":3,"numAtRisk":3,"numEvents":3},{"groupId":"EG005","numAffected":2,"numAtRisk":4,"numEvents":3},{"groupId":"EG006","numAffected":3,"numAtRisk":8,"numEvents":3},{"groupId":"EG007","numAffected":4,"numAtRisk":7,"numEvents":7},{"groupId":"EG008","numAffected":3,"numAtRisk":8,"numEvents":4}],"term":"Nausea"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA (20.1)","stats":[{"groupId":"EG000","numAffected":8,"numAtRisk":28,"numEvents":13},{"groupId":"EG001","numAffected":7,"numAtRisk":30,"numEvents":7},{"groupId":"EG002","numAffected":5,"numAtRisk":32,"numEvents":7},{"groupId":"EG003","numAffected":1,"numAtRisk":2,"numEvents":1},{"groupId":"EG004","numAffected":3,"numAtRisk":3,"numEvents":5},{"groupId":"EG005","numAffected":1,"numAtRisk":4,"numEvents":1},{"groupId":"EG006","numAffected":1,"numAtRisk":8,"numEvents":1},{"groupId":"EG007","numAffected":1,"numAtRisk":7,"numEvents":1},{"groupId":"EG008","numAffected":2,"numAtRisk":8,"numEvents":5}],"term":"Diarrhoea"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA 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All-Cause Mortality was assessed from the date of first dose of study drug (Part 1)/randomization (Part 2) until the date of death due to any cause (evaluated up to a maximum of 2196 days)."}