{"eventGroups":[{"deathsNumAffected":23,"deathsNumAtRisk":50,"description":"Patients receive panobinostat PO QD on days -9 to -2, gemcitabine hydrochloride IV over 4 hours on days -8 and -3, busulfan IV over 3 hours on days -8 to -5, and melphalan IV over 30 minutes on days -3 and -2. Patients then undergo autologous peripheral blood stem cell transplant on day 0.\n\nAutologous Hematopoietic Stem Cell Transplantation: Undergo autologous peripheral blood stem cell transplant\n\nBusulfan: Given IV\n\nGemcitabine Hydrochloride: Given IV\n\nMelphalan: Given IV\n\nPanobinostat: Given PO\n\nPeripheral Blood Stem Cell Transplantation: Undergo autologous peripheral blood stem cell transplant\n\nPharmacological Study: Correlative studies","id":"EG000","otherNumAffected":47,"otherNumAtRisk":50,"seriousNumAffected":2,"seriousNumAtRisk":50,"title":"Cohort 1_1st Auto TP Conditioned With Panobinostat and Gem/Bu/Mel"},{"deathsNumAffected":17,"deathsNumAtRisk":33,"description":"Patients receive panobinostat PO QD on days -9 to -2, gemcitabine hydrochloride IV over 4 hours on days -8 and -3, busulfan IV over 3 hours on days -8 to -5, and melphalan IV over 30 minutes on days -3 and -2. Patients then undergo autologous peripheral blood stem cell transplant on day 0.\n\nAutologous Hematopoietic Stem Cell Transplantation: Undergo autologous peripheral blood stem cell transplant\n\nBusulfan: Given IV\n\nGemcitabine Hydrochloride: Given IV\n\nMelphalan: Given IV\n\nPanobinostat: Given PO\n\nPeripheral Blood Stem Cell Transplantation: Undergo autologous peripheral blood stem cell transplant\n\nPharmacological Study: Correlative studies","id":"EG001","otherNumAffected":30,"otherNumAtRisk":33,"seriousNumAffected":4,"seriousNumAtRisk":33,"title":"Cohort 2_2nd Auto TP Conditioned With Panobinostat and Gem/Bu/Mel"}],"frequencyThreshold":"0","otherEvents":[{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":50,"numEvents":1},{"groupId":"EG001","numAffected":2,"numAtRisk":33,"numEvents":2}],"term":"Abdominal pain"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":50,"numEvents":2},{"groupId":"EG001","numAffected":3,"numAtRisk":33,"numEvents":3}],"term":"ALK increased"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Immune system disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":50,"numEvents":1},{"groupId":"EG001","numAffected":1,"numAtRisk":33,"numEvents":1}],"term":"Allergic reaction"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":25,"numAtRisk":50,"numEvents":25},{"groupId":"EG001","numAffected":20,"numAtRisk":33,"numEvents":20}],"term":"ALT increased"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Metabolism and nutrition disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":50,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":33,"numEvents":1}],"term":"Anorexia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":10,"numAtRisk":50,"numEvents":10},{"groupId":"EG001","numAffected":6,"numAtRisk":33,"numEvents":6}],"term":"AST increased"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":18,"numAtRisk":50,"numEvents":18},{"groupId":"EG001","numAffected":14,"numAtRisk":33,"numEvents":14}],"term":"Bacterial"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":50,"numEvents":1},{"groupId":"EG001","numAffected":0,"numAtRisk":33,"numEvents":0}],"term":"Bleeding (no GI no PUL)"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Eye disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":50,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":33,"numEvents":1}],"term":"Blurred vision"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Cardiac disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":50,"numEvents":1},{"groupId":"EG001","numAffected":0,"numAtRisk":33,"numEvents":0}],"term":"CD OTH"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Psychiatric disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":50,"numEvents":1},{"groupId":"EG001","numAffected":1,"numAtRisk":33,"numEvents":1}],"term":"Confusion"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Respiratory, thoracic and mediastinal disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":50,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":33,"numEvents":1}],"term":"Cough"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":7,"numAtRisk":50,"numEvents":7},{"groupId":"EG001","numAffected":6,"numAtRisk":33,"numEvents":6}],"term":"Creatinine increased"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"General disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":43,"numAtRisk":50,"numEvents":43},{"groupId":"EG001","numAffected":28,"numAtRisk":33,"numEvents":28}],"term":"Diarrhea"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Nervous system disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":50,"numEvents":3},{"groupId":"EG001","numAffected":0,"numAtRisk":33,"numEvents":0}],"term":"Dizziness"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Skin and subcutaneous tissue disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":50,"numEvents":1},{"groupId":"EG001","numAffected":0,"numAtRisk":33,"numEvents":0}],"term":"Dry skin"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":50,"numEvents":1},{"groupId":"EG001","numAffected":1,"numAtRisk":33,"numEvents":1}],"term":"Dysgeusia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Cardiac disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":10,"numAtRisk":50,"numEvents":10},{"groupId":"EG001","numAffected":7,"numAtRisk":33,"numEvents":7}],"term":"Dysrhythmia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Cardiac disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":50,"numEvents":1},{"groupId":"EG001","numAffected":1,"numAtRisk":33,"numEvents":1}],"term":"Ejection fraction decreased"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Immune system disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":50,"numEvents":1},{"groupId":"EG001","numAffected":2,"numAtRisk":33,"numEvents":2}],"term":"Engraftment syndrome"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"General disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":50,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":33,"numEvents":1}],"term":"Fatigue"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":43,"numAtRisk":50,"numEvents":43},{"groupId":"EG001","numAffected":28,"numAtRisk":33,"numEvents":28}],"term":"Febrile neutropenia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"General disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":11,"numAtRisk":50,"numEvents":11},{"groupId":"EG001","numAffected":7,"numAtRisk":33,"numEvents":7}],"term":"Fever"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"General disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":36,"numAtRisk":50,"numEvents":36},{"groupId":"EG001","numAffected":25,"numAtRisk":33,"numEvents":25}],"term":"Fluid overload"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":50,"numEvents":3},{"groupId":"EG001","numAffected":2,"numAtRisk":33,"numEvents":2}],"term":"Fungal"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":50,"numEvents":1},{"groupId":"EG001","numAffected":0,"numAtRisk":33,"numEvents":0}],"term":"GI OTH"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Psychiatric disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":50,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":33,"numEvents":1}],"term":"Hallucination"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Nervous system disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":4,"numAtRisk":50,"numEvents":4},{"groupId":"EG001","numAffected":3,"numAtRisk":33,"numEvents":3}],"term":"Headache"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Renal and urinary disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":50,"numEvents":1},{"groupId":"EG001","numAffected":1,"numAtRisk":33,"numEvents":1}],"term":"Hemorrhagic Cystitis"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Respiratory, thoracic and mediastinal disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":50,"numEvents":1},{"groupId":"EG001","numAffected":3,"numAtRisk":33,"numEvents":3}],"term":"Hiccups"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Vascular disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":10,"numAtRisk":50,"numEvents":10},{"groupId":"EG001","numAffected":9,"numAtRisk":33,"numEvents":9}],"term":"Hypertension"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Vascular disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":50,"numEvents":3},{"groupId":"EG001","numAffected":0,"numAtRisk":33,"numEvents":0}],"term":"Hypotension"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":46,"numAtRisk":50,"numEvents":46},{"groupId":"EG001","numAffected":30,"numAtRisk":33,"numEvents":30}],"term":"Nausea"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Nervous system disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":50,"numEvents":1},{"groupId":"EG001","numAffected":0,"numAtRisk":33,"numEvents":0}],"term":"NE OTH"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Nervous system disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":50,"numEvents":1},{"groupId":"EG001","numAffected":1,"numAtRisk":33,"numEvents":1}],"term":"NE VIS"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":47,"numAtRisk":50,"numEvents":47},{"groupId":"EG001","numAffected":26,"numAtRisk":33,"numEvents":26}],"term":"Oral 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subcutaneous tissue disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":27,"numAtRisk":50,"numEvents":27},{"groupId":"EG001","numAffected":23,"numAtRisk":33,"numEvents":23}],"term":"Rash"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Nervous system disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":50,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":33,"numEvents":1}],"term":"Somnolence"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":15,"numAtRisk":50,"numEvents":15},{"groupId":"EG001","numAffected":12,"numAtRisk":33,"numEvents":12}],"term":"T bilirubin increased"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Vascular disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":50,"numEvents":3},{"groupId":"EG001","numAffected":2,"numAtRisk":33,"numEvents":2}],"term":"Thromboembolic event"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Nervous system disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":50,"numEvents":1},{"groupId":"EG001","numAffected":0,"numAtRisk":33,"numEvents":0}],"term":"Tremor"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":18,"numAtRisk":50,"numEvents":18},{"groupId":"EG001","numAffected":23,"numAtRisk":33,"numEvents":23}],"term":"Viral"}],"seriousEvents":[{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":50,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":33,"numEvents":1}],"term":"AST increased"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":50,"numEvents":1},{"groupId":"EG001","numAffected":0,"numAtRisk":33,"numEvents":0}],"term":"Bleeding (no GI no PUL)"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":50,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":33,"numEvents":1}],"term":"Creatinine increased"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Respiratory, thoracic and mediastinal disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":50,"numEvents":1},{"groupId":"EG001","numAffected":0,"numAtRisk":33,"numEvents":0}],"term":"DAH"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":50,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":33,"numEvents":1}],"term":"Diarrhea"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Nervous system disorders","sourceVocabulary":"CTCAE (4.0)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":50,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":33,"numEvents":1}],"term":"Encephalopathy"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"CTCAE 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