{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0","upperLimit":"13","value":"0"},{"groupId":"OG001","lowerLimit":"0","upperLimit":"3","value":"0"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"37"},{"groupId":"OG001","value":"36"}],"units":"Participants"}],"description":"In addition to deriving severe (Grade 4) neutropenia using the method described for the primary endpoints, an approach was applied that accounted for participants who did not experience a severe neutropenia event in Cycle 1. For the post-hoc analysis, severe neutropenia was defined as at least 1 ANC value \\<0.5 × 10\\^9/L during the treatment period. In Cycle 1, the duration (days) of severe neutropenia was defined as the number of days from the date of the first ANC value of \\<0.5 × 10\\^9/L observed between start of cycle and end of cycle to the date of the first ANC value ≥0.5 × 10\\^9/L that met the following criteria: 1) occurred after the ANC value of \\<0.5 × 10\\^9/L and 2) no other ANC values \\<0.5 × 10\\^9/L occurred between this day and end of cycle. The duration of severe neutropenia was set to 0 for participants who did not experience severe neutropenia in Cycle 1. Data from unscheduled visits and the actual assessment date (rather than visit date) were included in the derivation.","dispersionType":"Full Range","groups":[{"description":"Participants received placebo IV once daily on Days 1 to 3 of each 21-day E/P chemotherapy cycle.","id":"OG000","title":"Part 2: Placebo"},{"description":"Participants received trilaciclib 240 mg/m\\^2 IV once daily on Days 1 to 3 of each 21-day E/P chemotherapy cycle.","id":"OG001","title":"Part 2: Trilaciclib 240 mg/m^2"}],"paramType":"MEDIAN","populationDescription":"The FAS included all randomized patients who received at least 1 dose of study drug (etoposide, carboplatin, or trilaciclib). Analyses using the FAS were conducted on the basis of the assigned treatment.","reportingStatus":"POSTED","timeFrame":"From baseline to the end of Cycle 1","title":"Duration of Severe (Grade 4) Neutropenia in Cycle 1 of Part 2","type":"POST_HOC","unitOfMeasure":"Days"}