{"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}],"groups":[{"description":"Participants received ponatinib 45 mg orally once daily in each 28-day cycle until achievement of ≤1% BCR-ABL1IS. Once ≤1% BCR-ABL1IS was achieved, participants received reduced dose of ponatinib 15 mg orally once daily.","id":"BG000","title":"Treatment Period: Cohort A: Ponatinib 45 mg"},{"description":"Participants received ponatinib 30 mg orally once daily in each 28-day cycle until achievement of ≤1% BCR-ABL1IS. Once ≤1% BCR-ABL1IS was achieved, participants received reduced dose of ponatinib 15 mg orally once daily.","id":"BG001","title":"Treatment Period: Cohort B: Ponatinib 30 mg"},{"description":"Participants received ponatinib 15 mg orally once daily in each 28-day cycle.","id":"BG002","title":"Treatment Period: Cohort C: Ponatinib 15 mg"},{"description":"Total of all reporting groups","id":"BG003","title":"Total"}],"measures":[{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","spread":"14.77","value":"47.7"},{"groupId":"BG001","spread":"12.90","value":"48.5"},{"groupId":"BG002","spread":"12.71","value":"48.8"},{"groupId":"BG003","spread":"13.45","value":"48.3"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}]}],"dispersionType":"STANDARD_DEVIATION","paramType":"MEAN","title":"Age, Continuous","unitOfMeasure":"years"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"44"},{"groupId":"BG001","value":"56"},{"groupId":"BG002","value":"41"},{"groupId":"BG003","value":"141"}],"title":"Female"},{"measurements":[{"groupId":"BG000","value":"50"},{"groupId":"BG001","value":"38"},{"groupId":"BG002","value":"53"},{"groupId":"BG003","value":"141"}],"title":"Male"}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}]}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Sex: Female, Male","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"22"},{"groupId":"BG001","value":"26"},{"groupId":"BG002","value":"20"},{"groupId":"BG003","value":"68"}],"title":"Hispanic or Latino"},{"measurements":[{"groupId":"BG000","value":"70"},{"groupId":"BG001","value":"67"},{"groupId":"BG002","value":"72"},{"groupId":"BG003","value":"209"}],"title":"Not Hispanic or Latino"},{"measurements":[{"groupId":"BG000","value":"2"},{"groupId":"BG001","value":"1"},{"groupId":"BG002","value":"2"},{"groupId":"BG003","value":"5"}],"title":"Unknown or Not Reported"}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}]}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Ethnicity (NIH/OMB)","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"16"},{"groupId":"BG001","value":"12"},{"groupId":"BG002","value":"15"},{"groupId":"BG003","value":"43"}],"title":"Asian"},{"measurements":[{"groupId":"BG000","value":"1"},{"groupId":"BG001","value":"2"},{"groupId":"BG002","value":"3"},{"groupId":"BG003","value":"6"}],"title":"Black or African American"},{"measurements":[{"groupId":"BG000","value":"73"},{"groupId":"BG001","value":"77"},{"groupId":"BG002","value":"72"},{"groupId":"BG003","value":"222"}],"title":"White"},{"measurements":[{"groupId":"BG000","value":"0"},{"groupId":"BG001","value":"1"},{"groupId":"BG002","value":"3"},{"groupId":"BG003","value":"4"}],"title":"Unknown"},{"measurements":[{"groupId":"BG000","value":"2"},{"groupId":"BG001","value":"1"},{"groupId":"BG002","value":"0"},{"groupId":"BG003","value":"3"}],"title":"Other"},{"measurements":[{"groupId":"BG000","value":"2"},{"groupId":"BG001","value":"1"},{"groupId":"BG002","value":"1"},{"groupId":"BG003","value":"4"}],"title":"Missing"}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}],"title":"Race"}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Race/Ethnicity, Customized","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"15"},{"groupId":"BG001","value":"16"},{"groupId":"BG002","value":"7"},{"groupId":"BG003","value":"38"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}],"title":"Argentina"},{"categories":[{"measurements":[{"groupId":"BG000","value":"0"},{"groupId":"BG001","value":"0"},{"groupId":"BG002","value":"2"},{"groupId":"BG003","value":"2"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}],"title":"Austria"},{"categories":[{"measurements":[{"groupId":"BG000","value":"7"},{"groupId":"BG001","value":"9"},{"groupId":"BG002","value":"9"},{"groupId":"BG003","value":"25"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}],"title":"Chile"},{"categories":[{"measurements":[{"groupId":"BG000","value":"0"},{"groupId":"BG001","value":"0"},{"groupId":"BG002","value":"1"},{"groupId":"BG003","value":"1"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}],"title":"Denmark"},{"categories":[{"measurements":[{"groupId":"BG000","value":"2"},{"groupId":"BG001","value":"1"},{"groupId":"BG002","value":"2"},{"groupId":"BG003","value":"5"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}],"title":"France"},{"categories":[{"measurements":[{"groupId":"BG000","value":"1"},{"groupId":"BG001","value":"4"},{"groupId":"BG002","value":"7"},{"groupId":"BG003","value":"12"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}],"title":"United Kingdom"},{"categories":[{"measurements":[{"groupId":"BG000","value":"1"},{"groupId":"BG001","value":"3"},{"groupId":"BG002","value":"2"},{"groupId":"BG003","value":"6"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}],"title":"Hong Kong"},{"categories":[{"measurements":[{"groupId":"BG000","value":"0"},{"groupId":"BG001","value":"3"},{"groupId":"BG002","value":"0"},{"groupId":"BG003","value":"3"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}],"title":"Italy"},{"categories":[{"measurements":[{"groupId":"BG000","value":"5"},{"groupId":"BG001","value":"2"},{"groupId":"BG002","value":"4"},{"groupId":"BG003","value":"11"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}],"title":"Japan"},{"categories":[{"measurements":[{"groupId":"BG000","value":"4"},{"groupId":"BG001","value":"6"},{"groupId":"BG002","value":"5"},{"groupId":"BG003","value":"15"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}],"title":"Poland"},{"categories":[{"measurements":[{"groupId":"BG000","value":"38"},{"groupId":"BG001","value":"31"},{"groupId":"BG002","value":"38"},{"groupId":"BG003","value":"107"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}],"title":"Russia"},{"categories":[{"measurements":[{"groupId":"BG000","value":"4"},{"groupId":"BG001","value":"3"},{"groupId":"BG002","value":"2"},{"groupId":"BG003","value":"9"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}],"title":"Singapore"},{"categories":[{"measurements":[{"groupId":"BG000","value":"0"},{"groupId":"BG001","value":"3"},{"groupId":"BG002","value":"2"},{"groupId":"BG003","value":"5"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}],"title":"Korea, Republic Of"},{"categories":[{"measurements":[{"groupId":"BG000","value":"3"},{"groupId":"BG001","value":"0"},{"groupId":"BG002","value":"2"},{"groupId":"BG003","value":"5"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}],"title":"Spain"},{"categories":[{"measurements":[{"groupId":"BG000","value":"0"},{"groupId":"BG001","value":"2"},{"groupId":"BG002","value":"1"},{"groupId":"BG003","value":"3"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}],"title":"Sweden"},{"categories":[{"measurements":[{"groupId":"BG000","value":"4"},{"groupId":"BG001","value":"1"},{"groupId":"BG002","value":"2"},{"groupId":"BG003","value":"7"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}],"title":"Taiwan, Province Of China"},{"categories":[{"measurements":[{"groupId":"BG000","value":"10"},{"groupId":"BG001","value":"8"},{"groupId":"BG002","value":"7"},{"groupId":"BG003","value":"25"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}],"title":"United States"},{"categories":[{"measurements":[{"groupId":"BG000","value":"0"},{"groupId":"BG001","value":"1"},{"groupId":"BG002","value":"0"},{"groupId":"BG003","value":"1"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}],"title":"Canada"},{"categories":[{"measurements":[{"groupId":"BG000","value":"0"},{"groupId":"BG001","value":"1"},{"groupId":"BG002","value":"1"},{"groupId":"BG003","value":"2"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}],"title":"Portugal"}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Region of Enrollment","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","spread":"20.841","value":"78.14"},{"groupId":"BG001","spread":"18.375","value":"77.56"},{"groupId":"BG002","spread":"17.434","value":"76.71"},{"groupId":"BG003","spread":"18.879","value":"77.47"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}]}],"dispersionType":"STANDARD_DEVIATION","paramType":"MEAN","title":"Weight","unitOfMeasure":"kg"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","spread":"0.104","value":"1.68"},{"groupId":"BG001","spread":"0.098","value":"1.68"},{"groupId":"BG002","spread":"0.090","value":"1.68"},{"groupId":"BG003","spread":"0.097","value":"1.68"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"91"},{"groupId":"BG002","value":"92"},{"groupId":"BG003","value":"277"}],"units":"Participants"}]}],"dispersionType":"STANDARD_DEVIATION","paramType":"MEAN","populationDescription":"Number analyzed is the number of participants with data available for height at Baseline.","title":"Height","unitOfMeasure":"meter"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"74"},{"groupId":"BG001","value":"73"},{"groupId":"BG002","value":"72"},{"groupId":"BG003","value":"219"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}],"title":"Score= 0"},{"categories":[{"measurements":[{"groupId":"BG000","value":"19"},{"groupId":"BG001","value":"20"},{"groupId":"BG002","value":"22"},{"groupId":"BG003","value":"61"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}],"title":"Score= 1"},{"categories":[{"measurements":[{"groupId":"BG000","value":"1"},{"groupId":"BG001","value":"1"},{"groupId":"BG002","value":"0"},{"groupId":"BG003","value":"2"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}],"title":"Score= 2"}],"description":"ECOG performance status is used by doctors and researchers to assess how a participant's disease is progressing, assess how the disease affects the daily living activities of the participant and determine appropriate treatment and prognosis. 0 = Fully Active (Most Favorable Activity); 1 = Restricted activity but ambulatory; 2 = Ambulatory but unable to carry out work activities; 3 = Limited Self-Care; 4 = Completely Disabled, No self-care (Least Favorable Activity). Only categories with data are reported.","paramType":"COUNT_OF_PARTICIPANTS","title":"Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) Score","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"51"},{"groupId":"BG001","value":"52"},{"groupId":"BG002","value":"52"},{"groupId":"BG003","value":"155"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}],"title":"<60/No"},{"categories":[{"measurements":[{"groupId":"BG000","value":"19"},{"groupId":"BG001","value":"19"},{"groupId":"BG002","value":"19"},{"groupId":"BG003","value":"57"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}],"title":"<60/Yes"},{"categories":[{"measurements":[{"groupId":"BG000","value":"7"},{"groupId":"BG001","value":"7"},{"groupId":"BG002","value":"7"},{"groupId":"BG003","value":"21"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}],"title":">=60/No"},{"categories":[{"measurements":[{"groupId":"BG000","value":"17"},{"groupId":"BG001","value":"16"},{"groupId":"BG002","value":"16"},{"groupId":"BG003","value":"49"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}],"title":">=60/Yes"}],"description":"Randomization stratum is based on Age (years)/History of Hypertension, Diabetes, or Hyperlipidemia. The number in the reported categories denotes age and Yes or No indicates history of hypertension, diabetes or hyperlipidemia was present or absent. '\\<' indicates less than and '\\>=' indicates greater than equal to in the reported categories.","paramType":"COUNT_OF_PARTICIPANTS","title":"Randomization Stratum","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","spread":"5.41","value":"7.4"},{"groupId":"BG001","spread":"6.32","value":"7.6"},{"groupId":"BG002","spread":"5.36","value":"7.1"},{"groupId":"BG003","spread":"5.7","value":"7.4"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"92"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"280"}],"units":"Participants"}]}],"dispersionType":"STANDARD_DEVIATION","paramType":"MEAN","populationDescription":"Number analyzed is the number of participants with data available for analysis.","title":"Time Since Diagnosis","unitOfMeasure":"years"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"85"},{"groupId":"BG001","value":"84"},{"groupId":"BG002","value":"86"},{"groupId":"BG003","value":"255"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}],"title":"Imatinib"},{"categories":[{"measurements":[{"groupId":"BG000","value":"68"},{"groupId":"BG001","value":"76"},{"groupId":"BG002","value":"68"},{"groupId":"BG003","value":"212"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}],"title":"Dasatinib"},{"categories":[{"measurements":[{"groupId":"BG000","value":"74"},{"groupId":"BG001","value":"72"},{"groupId":"BG002","value":"73"},{"groupId":"BG003","value":"219"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}],"title":"Nilotinib"},{"categories":[{"measurements":[{"groupId":"BG000","value":"18"},{"groupId":"BG001","value":"19"},{"groupId":"BG002","value":"17"},{"groupId":"BG003","value":"54"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}],"title":"Bosutinib"},{"categories":[{"measurements":[{"groupId":"BG000","value":"0"},{"groupId":"BG001","value":"1"},{"groupId":"BG002","value":"1"},{"groupId":"BG003","value":"2"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}],"title":"Radotinib"}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Prior Tyrosine Kinase Inhibitor (TKIs)","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"1"},{"groupId":"BG001","value":"1"},{"groupId":"BG002","value":"4"},{"groupId":"BG003","value":"6"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}],"title":"1"},{"categories":[{"measurements":[{"groupId":"BG000","value":"43"},{"groupId":"BG001","value":"37"},{"groupId":"BG002","value":"42"},{"groupId":"BG003","value":"122"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}],"title":"2"},{"categories":[{"measurements":[{"groupId":"BG000","value":"42"},{"groupId":"BG001","value":"47"},{"groupId":"BG002","value":"35"},{"groupId":"BG003","value":"124"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}],"title":"3"},{"categories":[{"measurements":[{"groupId":"BG000","value":"8"},{"groupId":"BG001","value":"9"},{"groupId":"BG002","value":"13"},{"groupId":"BG003","value":"30"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"94"},{"groupId":"BG002","value":"94"},{"groupId":"BG003","value":"282"}],"units":"Participants"}],"title":"4"}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Number of Prior Approved TKIs","unitOfMeasure":"Participants"},{"calculatePct":false,"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"51"},{"groupId":"BG001","value":"58"},{"groupId":"BG002","value":"54"},{"groupId":"BG003","value":"163"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"92"},{"groupId":"BG001","value":"93"},{"groupId":"BG002","value":"93"},{"groupId":"BG003","value":"278"}],"units":"Participants"}],"title":"No mutation detected"},{"categories":[{"measurements":[{"groupId":"BG000","value":"41"},{"groupId":"BG001","value":"35"},{"groupId":"BG002","value":"39"},{"groupId":"BG003","value":"115"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"92"},{"groupId":"BG001","value":"93"},{"groupId":"BG002","value":"93"},{"groupId":"BG003","value":"278"}],"units":"Participants"}],"title":"1 or more mutations detected"}],"paramType":"COUNT_OF_PARTICIPANTS","populationDescription":"Number analyzed is the total number of participants (n=278) with data available for analysis, excluding 4 participants who did not have mutation test result at baseline (2 in Cohort A, 1 in Cohort B, 1 in Cohort C).","title":"Mutations at Baseline","unitOfMeasure":"Participants"}],"populationDescription":"Safety Population included all participants who received at least one dose of study drug."}