{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0.0","upperLimit":"20.6","value":"0"},{"groupId":"OG001","lowerLimit":"0.0","upperLimit":"22.1","value":"0"},{"groupId":"OG002","lowerLimit":"0.0","upperLimit":"39.3","value":"0"},{"groupId":"OG003","lowerLimit":"0.0","upperLimit":"39.3","value":"0"},{"groupId":"OG004","lowerLimit":"0.0","upperLimit":"39.3","value":"0"},{"groupId":"OG005","lowerLimit":"0.0","upperLimit":"11.3","value":"0"},{"groupId":"OG006","lowerLimit":"0.0","upperLimit":"11.7","value":"0"},{"groupId":"OG007","lowerLimit":"0.0","upperLimit":"45.1","value":"0"},{"groupId":"OG008","lowerLimit":"0.0","upperLimit":"39.3","value":"0"},{"groupId":"OG009","lowerLimit":"0.0","upperLimit":"23.8","value":"0"},{"groupId":"OG010","lowerLimit":"0.0","upperLimit":"45.1","value":"0"},{"groupId":"OG011","lowerLimit":"6.3","upperLimit":"72.9","value":"33.3"},{"groupId":"OG012","lowerLimit":"0.0","upperLimit":"39.3","value":"0"},{"groupId":"OG013","lowerLimit":"0.9","upperLimit":"58.2","value":"16.7"},{"groupId":"OG014","lowerLimit":"0.0","upperLimit":"45.1","value":"0"},{"groupId":"OG015","lowerLimit":"0.9","upperLimit":"58.2","value":"16.7"},{"groupId":"OG016","lowerLimit":"7.1","upperLimit":"40.1","value":"20.0"},{"groupId":"OG017","lowerLimit":"6.3","upperLimit":"72.9","value":"33.3"},{"groupId":"OG018","lowerLimit":"0.0","upperLimit":"22.1","value":"0"},{"groupId":"OG019","lowerLimit":"0.0","upperLimit":"34.8","value":"0"},{"groupId":"OG020","lowerLimit":"0.0","upperLimit":"39.3","value":"0"},{"groupId":"OG021","lowerLimit":"12.3","upperLimit":"60.9","value":"33.3"},{"groupId":"OG022","lowerLimit":"0.0","upperLimit":"39.3","value":"0"},{"groupId":"OG023","lowerLimit":"0.0","upperLimit":"23.8","value":"0"},{"groupId":"OG024","lowerLimit":"0.9","upperLimit":"58.2","value":"16.7"},{"groupId":"OG025","lowerLimit":"0.0","upperLimit":"39.3","value":"0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"13"},{"groupId":"OG001","value":"12"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"6"},{"groupId":"OG004","value":"6"},{"groupId":"OG005","value":"25"},{"groupId":"OG006","value":"24"},{"groupId":"OG007","value":"5"},{"groupId":"OG008","value":"6"},{"groupId":"OG009","value":"11"},{"groupId":"OG010","value":"5"},{"groupId":"OG011","value":"6"},{"groupId":"OG012","value":"6"},{"groupId":"OG013","value":"6"},{"groupId":"OG014","value":"5"},{"groupId":"OG015","value":"6"},{"groupId":"OG016","value":"20"},{"groupId":"OG017","value":"6"},{"groupId":"OG018","value":"12"},{"groupId":"OG019","value":"7"},{"groupId":"OG020","value":"6"},{"groupId":"OG021","value":"12"},{"groupId":"OG022","value":"6"},{"groupId":"OG023","value":"11"},{"groupId":"OG024","value":"6"},{"groupId":"OG025","value":"6"}],"units":"Participants"}],"title":"ROW"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0.0","upperLimit":"52.7","value":"0"},{"groupId":"OG005","lowerLimit":"0.0","upperLimit":"45.1","value":"0"},{"groupId":"OG006","lowerLimit":"0.0","upperLimit":"39.3","value":"0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"4"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"},{"groupId":"OG004","value":"0"},{"groupId":"OG005","value":"5"},{"groupId":"OG006","value":"6"},{"groupId":"OG007","value":"0"},{"groupId":"OG008","value":"0"},{"groupId":"OG009","value":"0"},{"groupId":"OG010","value":"0"},{"groupId":"OG011","value":"0"},{"groupId":"OG012","value":"0"},{"groupId":"OG013","value":"0"},{"groupId":"OG014","value":"0"},{"groupId":"OG015","value":"0"},{"groupId":"OG016","value":"0"},{"groupId":"OG017","value":"0"},{"groupId":"OG018","value":"0"},{"groupId":"OG019","value":"0"},{"groupId":"OG020","value":"0"},{"groupId":"OG021","value":"0"},{"groupId":"OG022","value":"0"},{"groupId":"OG023","value":"0"},{"groupId":"OG024","value":"0"},{"groupId":"OG025","value":"0"}],"units":"Participants"}],"title":"Japanese"}],"denoms":[{"counts":[{"groupId":"OG000","value":"17"},{"groupId":"OG001","value":"12"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"6"},{"groupId":"OG004","value":"6"},{"groupId":"OG005","value":"30"},{"groupId":"OG006","value":"30"},{"groupId":"OG007","value":"5"},{"groupId":"OG008","value":"6"},{"groupId":"OG009","value":"11"},{"groupId":"OG010","value":"5"},{"groupId":"OG011","value":"6"},{"groupId":"OG012","value":"6"},{"groupId":"OG013","value":"6"},{"groupId":"OG014","value":"5"},{"groupId":"OG015","value":"6"},{"groupId":"OG016","value":"20"},{"groupId":"OG017","value":"6"},{"groupId":"OG018","value":"12"},{"groupId":"OG019","value":"7"},{"groupId":"OG020","value":"6"},{"groupId":"OG021","value":"12"},{"groupId":"OG022","value":"6"},{"groupId":"OG023","value":"11"},{"groupId":"OG024","value":"6"},{"groupId":"OG025","value":"6"}],"units":"Participants"}],"description":"TTumor response was based on local investigator assessment and the assessment criteria was immune-related Response Criteria (irRC). ORR per irRC is defined as the percentage of participants with a best overall response of immune related Complete Response (irCR) or immune related Partial Response (irPR).\n\nFor irRC, irCR=Disappearance of all non-nodal target lesions and non-target lesions. In addition, any pathological lymph nodes assigned as target lesions must have a reduction in short axis to \\< 10 mm; irPR= At least a 30% decrease in the sum of diameters of all target lesions including new target lesions, taking as reference the baseline sum of diameters.\n\nORR is reported for ROW and Japanese patients.","dispersionType":"90% Confidence Interval","groups":[{"description":"Single-agent LAG525 1 mg/kg Q2W","id":"OG000","title":"Phase 1: LAG525 1 mg/kg Q2W"},{"description":"Single-agent LAG525 3 mg/kg Q2W","id":"OG001","title":"Phase 1: LAG525 3 mg/kg Q2W"},{"description":"Single-agent LAG525 5 mg/kg Q2W","id":"OG002","title":"Phase 1: LAG525 5 mg/kg Q2W"},{"description":"Single-agent LAG525 10 mg/kg Q2W","id":"OG003","title":"Phase 1: LAG525 10 mg/kg Q2W"},{"description":"Single-agent LAG525 15 mg/kg Q2W","id":"OG004","title":"Phase 1: LAG525 15 mg/kg Q2W"},{"description":"Single-agent LAG525 240 mg Q2W","id":"OG005","title":"Phase 1: LAG525 240 mg Q2W"},{"description":"Single-agent LAG525 400 mg Q2W","id":"OG006","title":"Phase 1: LAG525 400 mg Q2W"},{"description":"Single-agent LAG525 3 mg/kg Q4W","id":"OG007","title":"Phase 1: LAG525 3 mg/kg Q4W"},{"description":"Single-agent LAG525 5 mg/kg Q4W","id":"OG008","title":"Phase 1: LAG525 5 mg/kg Q4W"},{"description":"Single-agent LAG525 10 mg/kg Q4W","id":"OG009","title":"Phase 1: LAG525 10 mg/kg Q4W"},{"description":"Single-agent LAG525 400 mg Q4W","id":"OG010","title":"Phase 1: LAG525 400 mg Q4W"},{"description":"Combination LAG525 0.3 mg/kg + PDR001 1 mg/kg (Q2W/Q2W)","id":"OG011","title":"Phase 1: LAG525 0.3 mg/kg Q2W + PDR001 1 mg/kg Q2W"},{"description":"Combination LAG525 1 mg/kg + PDR001 1 mg/kg (Q2W/Q2W)","id":"OG012","title":"Phase 1: LAG525 1 mg/kg Q2W + PDR001 1 mg/kg Q2W"},{"description":"Combination LAG525 80 mg + PDR001 80 mg (Q2W/Q2W)","id":"OG013","title":"Phase 1: LAG525 80 mg Q2W + PDR001 80 mg Q2W"},{"description":"Combination LAG525 80 mg + PDR001 240 mg (Q2W/Q2W)","id":"OG014","title":"Phase 1: LAG525 80 mg Q2W + PDR001 240 mg Q2W"},{"description":"Combination LAG525 240 mg + PDR001 240 mg (Q2W/Q2W)","id":"OG015","title":"Phase 1: LAG525 240 mg Q2W + PDR001 240 mg Q2W"},{"description":"Combination LAG525 240 mg + PDR001 300 mg (Q3W/Q3W)","id":"OG016","title":"Phase 1: LAG525 240 mg Q3W + PDR001 300 mg Q3W"},{"description":"Combination LAG525 400 mg + PDR001 300 mg (Q3W/Q3W)","id":"OG017","title":"Phase 1: LAG525 400 mg Q3W + PDR001 300 mg Q3W"},{"description":"Combination LAG525 600 mg + PDR001 300 mg (Q3W/Q3W)","id":"OG018","title":"Phase 1: LAG525 600 mg Q3W + PDR001 300 mg Q3W"},{"description":"Combination LAG525 80 mg + PDR001 240 mg (Q4W/Q4W)","id":"OG019","title":"Phase 1: LAG525 80 mg Q4W + PDR001 240 mg Q4W"},{"description":"Combination LAG525 400 mg + PDR001 400 mg (Q4W/Q4W)","id":"OG020","title":"Phase 1: LAG525 400 mg Q4W + PDR001 400 mg Q4W"},{"description":"Combination LAG525 800 mg + PDR001 400 mg (Q4W/Q4W)","id":"OG021","title":"Phase 1: LAG525 800 mg Q4W + PDR001 400 mg Q4W"},{"description":"Combination LAG525 1000 mg + PDR001 400 mg (Q4W/Q4W)","id":"OG022","title":"Phase 1: LAG525 1000 mg Q4W + PDR001 400 mg Q4W"},{"description":"Combination LAG525 80 mg + PDR001 400 mg (Q2W/Q4W)","id":"OG023","title":"Phase 1: LAG525 80 mg Q2W + PDR001 400 mg Q4W"},{"description":"Combination LAG525 240 mg + PDR001 400 mg (Q2W/Q4W)","id":"OG024","title":"Phase 1: LAG525 240 mg Q2W + PDR001 400 mg Q4W"},{"description":"Combination LAG525 300 mg + PDR001 400 mg (Q2W/Q4W)","id":"OG025","title":"Phase 1: LAG525 300 mg Q2W + PDR001 400 mg Q4W"}],"paramType":"NUMBER","populationDescription":"All patients in phase 1 who received at least one full or partial dose of LAG525 or PDR001.","reportingStatus":"POSTED","timeFrame":"From start of treatment until end of treatment, assessed up to 4.4 years","title":"Phase 1: Overall Response Rate (ORR) Per irRC","type":"SECONDARY","unitOfMeasure":"percentage of participants"}