{"classes":[{"categories":[{"measurements":[{"groupId":"OG001","lowerLimit":"2.00","upperLimit":"4.00","value":"2.00"},{"groupId":"OG002","lowerLimit":"1.00","upperLimit":"3.00","value":"2.00"},{"groupId":"OG003","lowerLimit":"1.00","upperLimit":"3.00","value":"2.00"},{"groupId":"OG004","lowerLimit":"2.00","upperLimit":"6.00","value":"4.00"},{"groupId":"OG005","lowerLimit":"1.00","upperLimit":"3.00","value":"2.00"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"5"},{"groupId":"OG002","value":"3"},{"groupId":"OG003","value":"5"},{"groupId":"OG004","value":"4"},{"groupId":"OG005","value":"6"}],"units":"Participants"}],"title":"Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1.00"},{"groupId":"OG001","lowerLimit":"1.00","upperLimit":"2.00","value":"1.50"},{"groupId":"OG002","value":"24.0"},{"groupId":"OG003","lowerLimit":"0.500","upperLimit":"2.00","value":"1.00"},{"groupId":"OG004","value":"2.00"},{"groupId":"OG005","lowerLimit":"2.00","upperLimit":"2.00","value":"2.00"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"1"},{"groupId":"OG003","value":"3"},{"groupId":"OG004","value":"1"},{"groupId":"OG005","value":"2"}],"units":"Participants"}],"title":"Steady State"}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"5"},{"groupId":"OG002","value":"3"},{"groupId":"OG003","value":"5"},{"groupId":"OG004","value":"4"},{"groupId":"OG005","value":"6"}],"units":"Participants"}],"dispersionType":"Full Range","groups":[{"description":"Concurrent or intermittent dosing of cobimetinib 80 mg, concurrent with GDC-0994 300 mg for 21 consecutive days, followed by 7 days off.","id":"OG000","title":"COB 80 mg + GDC 300 mg"},{"description":"Concurrent or intermittent dosing of cobimetinib 20 mg, concurrent with GDC-0994 200 mg for 21 consecutive days, followed by 7 days off.","id":"OG001","title":"COB 20 mg + GDC 200 mg"},{"description":"Concurrent or intermittent dosing of cobimetinib 40 mg, concurrent with GDC-0994 200 mg for 21 consecutive days, followed by 7 days off.","id":"OG002","title":"COB 40 mg + GDC 200 mg"},{"description":"Concurrent or intermittent dosing of cobimetinib 80 mg, concurrent with GDC-0994 200 mg for 21 consecutive days, followed by 7 days off.","id":"OG003","title":"COB 80 mg + GDC 200 mg"},{"description":"Concurrent or intermittent dosing of cobimetinib 80 mg, concurrent with GDC-0994 400 mg for 21 consecutive days, followed by 7 days off.","id":"OG004","title":"COB 80 mg + GDC 400 mg"},{"description":"Concurrent or intermittent dosing of cobimetinib 100 mg, concurrent with GDC-0994 200 mg for 21 consecutive days, followed by 7 days off.","id":"OG005","title":"COB 100 mg + GDC 200 mg"}],"paramType":"MEDIAN","populationDescription":"Data are reported for evaluable participants.","reportingStatus":"POSTED","timeFrame":"Up to Day 22","title":"Median Time to Maximum Serum Concentration (Tmax) for Cobimetinib","type":"SECONDARY","unitOfMeasure":"hours"}