{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"178","value":"686"},{"groupId":"OG001","spread":"628","value":"611"},{"groupId":"OG002","spread":"409","value":"883"},{"groupId":"OG003","spread":"1660","value":"1150"},{"groupId":"OG004","spread":"1690","value":"2130"},{"groupId":"OG005","spread":"1560","value":"1970"},{"groupId":"OG006","spread":"843","value":"995"},{"comment":"Dose dependent parameter and overall summary not provided.","groupId":"OG007","spread":"NA","value":"NA"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"4"},{"groupId":"OG001","value":"5"},{"groupId":"OG002","value":"4"},{"groupId":"OG003","value":"4"},{"groupId":"OG004","value":"14"},{"groupId":"OG005","value":"12"},{"groupId":"OG006","value":"8"},{"groupId":"OG007","value":"51"}],"units":"Participants"}],"description":"AUC0-t is the area under the plasma or serum concentration-time curve from time = 0 to the last measurable concentration at time = t measured at steady state (Day 15).\n\nStudy drug was administered with 240 mL of water.","dispersionType":"Standard Deviation","groups":[{"description":"INCB054329 Monotherapy","id":"OG000","title":"INCB054329 Monotherapy - 15 mg QD"},{"description":"INCB054329 Monotherapy","id":"OG001","title":"INCB054329 Monotherapy - 15 mg BID"},{"description":"INCB054329 Monotherapy","id":"OG002","title":"INCB054329 Monotherapy - 22.5 mg QD"},{"description":"INCB054329 Monotherapy","id":"OG003","title":"INCB054329 Monotherapy - 30 mg QD"},{"description":"INCB054329 Monotherapy","id":"OG004","title":"INCB054329 Monotherapy - 20 mg BID"},{"description":"INCB054329 Monotherapy","id":"OG005","title":"INCB054329 Monotherapy - 22.5 mg BID"},{"description":"INCB054329 Monotherapy","id":"OG006","title":"INCB054329 Monotherapy - 25 mg BID"},{"description":"INCB054329 Monotherapy","id":"OG007","title":"INCB054329 Monotherapy - Overall Dosing Regimen"}],"paramType":"MEAN","populationDescription":"All enrolled patients who received at least 1 dose of study medication and provided at least 1 plasma sample were included.","reportingStatus":"POSTED","timeFrame":"Summary of steady-state PK parameters by dosing regimen at Day 15","title":"AUC0-t Analysis of INCB054329","type":"SECONDARY","unitOfMeasure":"nM*h"}