{"analyses":[{"groupIds":["OG000"],"nonInferiorityType":"SUPERIORITY","pValue":".017","statisticalMethod":"Regression, Logistic"},{"groupIds":["OG001"],"nonInferiorityType":"SUPERIORITY","pValue":"0.337","statisticalMethod":"Regression, Logistic"}],"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.165","value":"-0.407"},{"groupId":"OG001","spread":"0.103","value":"0.0099"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"12"},{"groupId":"OG001","value":"13"}],"units":"Participants"}],"description":"Expression (up or down regulation) of genes involved in the stress response can be modulated through the beta-adrenergic pathway. The log2 RNA abundance is a means to normalize results to determine whether a gene is up regulated (value greater than 1) or down regulated (value less than 1). Differential change in log2 RNA abundance is defined by the fold change (FC) as log2FC=Log2(B)-Log2(A). Logarithmic measures are unitless. The change in the measure between two time points determines whether a gene has up-or down-regulated.","dispersionType":"Standard Error","groups":[{"description":"Patient's randomized to the Propranolol arm will be starting 7 days prior to transplant and continuing through 28 days post-transplant. Propranolol will start at 20mg twice daily and will be titrated to 40mg twice daily as tolerated. Both groups will come back to the hospital weekly in order to assess items such as patient's level of anxiety, depression, your adherence, and also to monitor for side effects. The patient's will complete questionnaires during your visit. These will take approximately 15 minutes to complete. This will continue for up to 7 total weeks for patient's on the Propranolol arm.\n\nPropranolol","id":"OG000","title":"Propranolol"},{"description":"Both groups will come back to the hospital weekly in order to assess items such as patient's level of anxiety, depression, your adherence, and also to monitor for side effects. The patient's will complete questionnaires during your visit. These will take approximately 15 minutes to complete. This will continue for 6 total weeks for patient's on the control arm.","id":"OG001","title":"Control Arm"}],"paramType":"MEAN","reportingStatus":"POSTED","timeFrame":"Baseline (Pre-Transplant); 4 weeks post-transplant","title":"Beta-adrenergically Mediated Gene Expression (Change From Baseline)","type":"PRIMARY","unitOfMeasure":"Unitless"}