{"analyses":[{"groupDescription":"Change from baseline to week 1 in plasma levels of estriol","groupIds":["OG000","OG001"],"nonInferiorityType":"OTHER","pValue":"0.043","statisticalMethod":"Wilcoxon (Mann-Whitney)"},{"groupDescription":"Change from baseline to week 3 in plasma levels of estriol","groupIds":["OG000","OG001"],"nonInferiorityType":"OTHER","pValue":"0.649","statisticalMethod":"Wilcoxon (Mann-Whitney)"},{"groupDescription":"Change from baseline to week 8 in plasma levels of estriol","groupIds":["OG000","OG001"],"nonInferiorityType":"OTHER","pValue":"0.588","statisticalMethod":"Wilcoxon (Mann-Whitney)"},{"groupDescription":"Change from baseline to week 12 in plasma levels of estriol","groupIds":["OG000","OG001"],"nonInferiorityType":"OTHER","pValue":"0.67","statisticalMethod":"Wilcoxon (Mann-Whitney)"}],"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-10.7","upperLimit":"0.0","value":"-1.7"},{"groupId":"OG001","lowerLimit":"0.0","upperLimit":"0.0","value":"0.0"}]}],"title":"Change between baseline and week 1"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-3.4","upperLimit":"0.5","value":"0.0"},{"groupId":"OG001","lowerLimit":"0.0","upperLimit":"0.0","value":"0.0"}]}],"title":"Change between baseline and week 3"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-5.0","upperLimit":"0.5","value":"0.0"},{"groupId":"OG001","lowerLimit":"0.0","upperLimit":"0.0","value":"0.0"}]}],"title":"Change between baseline and week 8"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-6.8","upperLimit":"0.5","value":"0.0"},{"groupId":"OG001","lowerLimit":"0.0","upperLimit":"0.0","value":"0.0"}]}],"title":"Change between baseline and week 12"}],"denoms":[{"counts":[{"groupId":"OG000","value":"50"},{"groupId":"OG001","value":"11"}],"units":"Participants"}],"description":"Change in plasma levels of estriol at weeks 1, 3, 8 and 12 compared to baseline","dispersionType":"Inter-Quartile Range","groups":[{"description":"Route: Vaginal. Administration by an applicator inserted deep inside the vagina Dose: 1 g of gel, containing 50 Mcg of estriol Dosage schedule: Weeks 1-3: single daily application Weeks 4-12: twice weekly administration","id":"OG000","title":"0.005% Estriol Vaginal Gel"},{"description":"Route: Vaginal. Administration by an applicator inserted deep inside the vagina Dose: 1 g of gel. Dosage schedule: Weeks 1-3: single daily application Weeks 4-12: twice weekly administration\n\nPlacebo","id":"OG001","title":"Placebo Vaginal Gel"}],"paramType":"MEDIAN","populationDescription":"postmenopausal women","reportingStatus":"POSTED","timeFrame":"Change from baseline to week 1, week 3, week 8 and week 12","title":"Variation in Plasma Levels of Estriol","type":"SECONDARY","unitOfMeasure":"pg/mL"}