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Participants also received lenalidomide 25 mg once daily on days 1-21 and dexamethasone 40 mg (oral or IV) on days 1, 8, and 15 of each cycle, and on day 22 of cycles 1 to 8.","id":"EG001","otherNumAffected":12,"otherNumAtRisk":12,"seriousNumAffected":5,"seriousNumAtRisk":12,"title":"RRMM Dose-evaluation: Carfilzomib 70 mg/m²"},{"deathsNumAffected":2,"deathsNumAtRisk":34,"description":"Participants with RRMM received treatment with carfilzomib, lenalidomide, and dexamethasone (KRd) for up to eighteen 28-day cycles, or until disease progression, patient withdrawal, stem cell transplant, or death.\n\nParticipants received carfilzomib on days 1, 8, and 15 of each cycle. The dose was 20 mg/m² on cycle 1, day 1, and 70 mg/m² thereafter. 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22.1","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":10},{"groupId":"EG001","numAffected":0,"numAtRisk":12},{"groupId":"EG002","numAffected":0,"numAtRisk":34},{"groupId":"EG003","numAffected":0,"numAtRisk":9},{"groupId":"EG004","numAffected":0,"numAtRisk":9},{"groupId":"EG005","numAffected":1,"numAtRisk":33}],"term":"Rash maculo-papular"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Vascular disorders","sourceVocabulary":"MedDRA 22.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10},{"groupId":"EG001","numAffected":0,"numAtRisk":12},{"groupId":"EG002","numAffected":0,"numAtRisk":34},{"groupId":"EG003","numAffected":0,"numAtRisk":9},{"groupId":"EG004","numAffected":0,"numAtRisk":9},{"groupId":"EG005","numAffected":0,"numAtRisk":33}],"term":"Hypertension"}],"timeFrame":"All-cause Mortality is reported from the enrollment date up to the end of study; maximum time on study was 30.6 months. Treatment-emergent adverse events are reported from the first dose of any study drug up to 30 days after the last dose of any study drug; median (range) duration of treatment with carfilzomib was 32 (1.1, 76.7) weeks in RRMM participants and 26 (1.0, 94.4) weeks in NDMM participants."}