{"groups":[{"description":"Patients receive nivolumab IV over 60 minutes once every two weeks. Treatment continues in the absence of disease progression or unacceptable toxicity. Patients undergo CT scan, MRI and blood sample collection throughout the study.\n\nBiospecimen Collection: Undergo blood sample collection\n\nComputed Tomography: Undergo CT scan\n\nMagnetic Resonance Imaging: Undergo MRI\n\nNivolumab: Given IV","id":"FG000","title":"Part A (Nivolumab)"},{"description":"Patients receive nivolumab IV over 30 minutes once every 4 weeks. Treatment continues in the absence of disease progression or unacceptable toxicity. Patients undergo CT scan, MRI and blood sample collection throughout the study.\n\nBiospecimen Collection: Undergo blood sample collection\n\nComputed Tomography: Undergo CT scan\n\nMagnetic Resonance Imaging: Undergo MRI\n\nNivolumab: Given IV","id":"FG001","title":"Part B Arm I (Nivolumab)"},{"description":"Patients receive nivolumab as in Arm I. Patients also receive ipilimumab IV over 30 minutes once every 8 weeks. Treatment continues in the absence of disease progression or unacceptable toxicity. Patients undergo CT scan, MRI and blood sample collection throughout the study.\n\nBiospecimen Collection: Undergo blood sample collection\n\nComputed Tomography: Undergo CT scan\n\nIpilimumab: Given IV\n\nMagnetic Resonance Imaging: Undergo MRI\n\nNivolumab: Given IV","id":"FG002","title":"Part B Arm II (Nivolumab, Ipilimumab)"}],"periods":[{"dropWithdraws":[{"reasons":[{"groupId":"FG000","numSubjects":"0"},{"groupId":"FG001","numSubjects":"3"},{"groupId":"FG002","numSubjects":"1"}],"type":"Withdrawal by Subject"},{"reasons":[{"groupId":"FG000","numSubjects":"0"},{"groupId":"FG001","numSubjects":"1"},{"groupId":"FG002","numSubjects":"3"}],"type":"Protocol Violation"},{"reasons":[{"groupId":"FG000","numSubjects":"2"},{"groupId":"FG001","numSubjects":"0"},{"groupId":"FG002","numSubjects":"0"}],"type":"Did not meet an eligibility criterion and not treated"}],"milestones":[{"achievements":[{"groupId":"FG000","numSubjects":"39"},{"groupId":"FG001","numSubjects":"53"},{"groupId":"FG002","numSubjects":"51"}],"type":"STARTED"},{"achievements":[{"groupId":"FG000","numSubjects":"37"},{"groupId":"FG001","numSubjects":"49"},{"groupId":"FG002","numSubjects":"47"}],"type":"COMPLETED"},{"achievements":[{"groupId":"FG000","numSubjects":"2"},{"groupId":"FG001","numSubjects":"4"},{"groupId":"FG002","numSubjects":"4"}],"type":"NOT COMPLETED"}],"title":"Overall Study"}]}