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Undergo surgery\n\nVincristine: Given IV\n\nVincristine Sulfate: Given IV","id":"BG000","title":"Regimen A (VDC/IE)"},{"description":"INDUCTION THERAPY: Patients receive Induction therapy as in Regimen A and receive ganitumab IV over 30-60 minutes or 60-120 minutes on day 1 of weeks 1, 3, 5, 7, 9, and 11.\n\nLOCAL CONTROL THERAPY: Between weeks 13-18, patients undergo surgery and/or radiation therapy.\n\nCONSOLIDATION THERAPY: Patients receive Consolidation therapy as in Regimen A and receive ganitumab IV over 30-60 minutes or 60-120 minutes on day 1 of weeks 7, 9, 11, 13, and 15.\n\nMETASTATIC SITE IRRADIATION: Patients with lung metastases undergo whole lung radiation and patients with bone metastases undergo definitive SBRT or EBRT.\n\nMAINTENANCE: Patients receive ganitumab IV over 30-60 minutes or 60-120 minutes every 3 weeks for 8 cycles.\n\nCyclophosphamide: Given IV\n\nDoxorubicin: Given IV\n\nDoxorubicin Hydrochloride: Given IV\n\nEtoposide: Given IV\n\nEtoposide Phosphate: Given IV\n\nExternal Beam Radiation Therapy: Undergo EBRT\n\nGanitumab: Given IV\n\nIfosfamide: Given IV\n\nStereotactic Radiosurgery: Undergo SBRT\n\nTherapeutic Surgical Procedure: Undergo surgery\n\nVincristine: Given IV\n\nVincristine Sulfate: Given IV","id":"BG001","title":"Regimen B (VDC/IE + Ganitumab)"},{"description":"Total of all reporting groups","id":"BG002","title":"Total"}],"measures":[{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"124"},{"groupId":"BG001","value":"123"},{"groupId":"BG002","value":"247"}],"title":"<=18 years"},{"measurements":[{"groupId":"BG000","value":"33"},{"groupId":"BG001","value":"32"},{"groupId":"BG002","value":"65"}],"title":"Between 18 and 65 years"},{"measurements":[{"groupId":"BG000","value":"0"},{"groupId":"BG001","value":"0"},{"groupId":"BG002","value":"0"}],"title":">=65 years"}]}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Age, Categorical","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","lowerLimit":"11.47","upperLimit":"18.09","value":"14.89"},{"groupId":"BG001","lowerLimit":"11.32","upperLimit":"18.11","value":"15.16"},{"groupId":"BG002","lowerLimit":"11.32","upperLimit":"18.09","value":"15.03"}]}]}],"dispersionType":"INTER_QUARTILE_RANGE","paramType":"MEAN","title":"Age, Continuous","unitOfMeasure":"years"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"71"},{"groupId":"BG001","value":"69"},{"groupId":"BG002","value":"140"}],"title":"Female"},{"measurements":[{"groupId":"BG000","value":"86"},{"groupId":"BG001","value":"86"},{"groupId":"BG002","value":"172"}],"title":"Male"}]}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Sex: Female, Male","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"28"},{"groupId":"BG001","value":"23"},{"groupId":"BG002","value":"51"}],"title":"Hispanic or 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Islander"},{"measurements":[{"groupId":"BG000","value":"5"},{"groupId":"BG001","value":"3"},{"groupId":"BG002","value":"8"}],"title":"Black or African American"},{"measurements":[{"groupId":"BG000","value":"128"},{"groupId":"BG001","value":"125"},{"groupId":"BG002","value":"253"}],"title":"White"},{"measurements":[{"groupId":"BG000","value":"2"},{"groupId":"BG001","value":"0"},{"groupId":"BG002","value":"2"}],"title":"More than one race"},{"measurements":[{"groupId":"BG000","value":"17"},{"groupId":"BG001","value":"21"},{"groupId":"BG002","value":"38"}],"title":"Unknown or Not Reported"}]}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Race (NIH/OMB)","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"144"},{"groupId":"BG001","value":"142"},{"groupId":"BG002","value":"286"}]}],"title":"United States"},{"categories":[{"measurements":[{"groupId":"BG000","value":"10"},{"groupId":"BG001","value":"11"},{"groupId":"BG002","value":"21"}]}],"title":"Canada"},{"categories":[{"measurements":[{"groupId":"BG000","value":"0"},{"groupId":"BG001","value":"1"},{"groupId":"BG002","value":"1"}]}],"title":"China"},{"categories":[{"measurements":[{"groupId":"BG000","value":"1"},{"groupId":"BG001","value":"0"},{"groupId":"BG002","value":"1"}]}],"title":"Guatemala"},{"categories":[{"measurements":[{"groupId":"BG000","value":"2"},{"groupId":"BG001","value":"1"},{"groupId":"BG002","value":"3"}]}],"title":"Puerto Rico"}],"paramType":"NUMBER","title":"Region of Enrollment","unitOfMeasure":"participants"}]}