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All-Cause Mortality includes all deaths collected on the study.","eventGroups":[{"deathsNumAffected":61,"deathsNumAtRisk":145,"description":"INDUCTION THERAPY: Patients receive Induction therapy with alternating cycles of VDC and IE given every 2 weeks for 6 cycles.\n\nLOCAL CONTROL THERAPY: Between weeks 13-18, patients undergo surgery and/or radiation therapy.\n\nCONSOLIDATION THERAPY: Patients receive Consolidation therapy with alternating cycles of VDC and IE given every 2 weeks for 8 cycles.\n\nMETASTATIC SITE IRRADIATION: Patients with lung metastases undergo whole lung radiation and patients with bone metastases undergo definitive SBRT or EBRT.\n\nCyclophosphamide: Given IV\n\nDoxorubicin: Given IV\n\nDoxorubicin Hydrochloride: Given IV\n\nEtoposide: Given IV\n\nEtoposide Phosphate: Given IV\n\nExternal Beam Radiation Therapy: Undergo EBRT\n\nIfosfamide: Given IV\n\nStereotactic Radiosurgery: Undergo SBRT\n\nTherapeutic Surgical Procedure: Undergo surgery\n\nVincristine: Given IV\n\nVincristine Sulfate: Given IV","id":"EG000","otherNumAffected":114,"otherNumAtRisk":145,"seriousNumAffected":3,"seriousNumAtRisk":145,"title":"Regimen A (VDC/IE)"},{"deathsNumAffected":67,"deathsNumAtRisk":150,"description":"INDUCTION THERAPY: Patients receive Induction therapy as in Regimen A and receive ganitumab IV over 30-60 minutes or 60-120 minutes on day 1 of weeks 1, 3, 5, 7, 9, and 11.\n\nLOCAL CONTROL THERAPY: Between weeks 13-18, patients undergo surgery and/or radiation therapy.\n\nCONSOLIDATION THERAPY: Patients receive Consolidation therapy as in Regimen A and receive ganitumab IV over 30-60 minutes or 60-120 minutes on day 1 of weeks 7, 9, 11, 13, and 15.\n\nMETASTATIC SITE IRRADIATION: Patients with lung metastases undergo whole lung radiation and patients with bone metastases undergo definitive SBRT or EBRT.\n\nMAINTENANCE: Patients receive ganitumab IV over 30-60 minutes or 60-120 minutes every 3 weeks for 8 cycles.\n\nCyclophosphamide: Given IV\n\nDoxorubicin: Given IV\n\nDoxorubicin Hydrochloride: Given IV\n\nEtoposide: Given IV\n\nEtoposide Phosphate: Given IV\n\nExternal Beam Radiation Therapy: Undergo EBRT\n\nGanitumab: Given IV\n\nIfosfamide: Given IV\n\nStereotactic Radiosurgery: Undergo SBRT\n\nTherapeutic Surgical Procedure: Undergo surgery\n\nVincristine: Given IV\n\nVincristine Sulfate: Given IV","id":"EG001","otherNumAffected":122,"otherNumAtRisk":150,"seriousNumAffected":45,"seriousNumAtRisk":150,"title":"Regimen B (VDC/IE + Ganitumab)"}],"frequencyThreshold":"0","otherEvents":[{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":145,"numEvents":3},{"groupId":"EG001","numAffected":7,"numAtRisk":150,"numEvents":7}],"term":"Anemia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system 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