{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-5.63","upperLimit":"-2.45","value":"-4.04"},{"groupId":"OG001","lowerLimit":"-5.73","upperLimit":"-2.54","value":"-4.14"},{"groupId":"OG002","lowerLimit":"-7.81","upperLimit":"-1.92","value":"-4.87"},{"groupId":"OG003","lowerLimit":"-8.01","upperLimit":"-1.63","value":"-4.82"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"248"},{"groupId":"OG001","value":"252"},{"groupId":"OG002","value":"67"},{"groupId":"OG003","value":"57"}],"units":"Participants"}],"title":"Dyspnoea, First 9 months"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-5.12","upperLimit":"-1.81","value":"-3.46"},{"groupId":"OG001","lowerLimit":"-5.24","upperLimit":"-1.96","value":"-3.60"},{"groupId":"OG002","lowerLimit":"-5.03","upperLimit":"1.81","value":"-1.61"},{"groupId":"OG003","lowerLimit":"-3.03","upperLimit":"4.39","value":"0.68"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"241"},{"groupId":"OG001","value":"246"},{"groupId":"OG002","value":"67"},{"groupId":"OG003","value":"57"}],"units":"Participants"}],"title":"Dyspnoea, week 1"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-5.87","upperLimit":"-2.00","value":"-3.94"},{"groupId":"OG001","lowerLimit":"-5.57","upperLimit":"-1.70","value":"-3.64"},{"groupId":"OG002","lowerLimit":"-6.01","upperLimit":"1.48","value":"-2.27"},{"groupId":"OG003","lowerLimit":"-9.08","upperLimit":"-0.98","value":"-5.03"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"236"},{"groupId":"OG001","value":"236"},{"groupId":"OG002","value":"66"},{"groupId":"OG003","value":"57"}],"units":"Participants"}],"title":"Dyspnoea, week 2"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-5.85","upperLimit":"-2.12","value":"-3.99"},{"groupId":"OG001","lowerLimit":"-5.14","upperLimit":"-1.41","value":"-3.27"},{"groupId":"OG002","lowerLimit":"-6.96","upperLimit":"0.77","value":"-3.09"},{"groupId":"OG003","lowerLimit":"-9.69","upperLimit":"-1.42","value":"-5.55"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"239"},{"groupId":"OG001","value":"237"},{"groupId":"OG002","value":"63"},{"groupId":"OG003","value":"57"}],"units":"Participants"}],"title":"Dyspnoea, week 3"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-6.59","upperLimit":"-3.02","value":"-4.81"},{"groupId":"OG001","lowerLimit":"-5.88","upperLimit":"-2.34","value":"-4.11"},{"groupId":"OG002","lowerLimit":"-8.72","upperLimit":"-1.99","value":"-5.35"},{"groupId":"OG003","lowerLimit":"-9.20","upperLimit":"-1.89","value":"-5.55"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"206"},{"groupId":"OG001","value":"211"},{"groupId":"OG002","value":"63"},{"groupId":"OG003","value":"53"}],"units":"Participants"}],"title":"Dyspnoea, week 4"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-5.53","upperLimit":"-1.50","value":"-3.51"},{"groupId":"OG001","lowerLimit":"-7.22","upperLimit":"-3.17","value":"-5.19"},{"groupId":"OG002","lowerLimit":"-10.06","upperLimit":"-1.39","value":"-5.72"},{"groupId":"OG003","lowerLimit":"-10.32","upperLimit":"-1.20","value":"-5.76"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"199"},{"groupId":"OG001","value":"196"},{"groupId":"OG002","value":"57"},{"groupId":"OG003","value":"55"}],"units":"Participants"}],"title":"Dyspnoea, week 5"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-6.47","upperLimit":"-2.56","value":"-4.51"},{"groupId":"OG001","lowerLimit":"-6.42","upperLimit":"-2.48","value":"-4.45"},{"groupId":"OG002","lowerLimit":"-8.53","upperLimit":"-1.12","value":"-4.83"},{"groupId":"OG003","lowerLimit":"-10.40","upperLimit":"-2.33","value":"-6.37"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"222"},{"groupId":"OG001","value":"214"},{"groupId":"OG002","value":"64"},{"groupId":"OG003","value":"53"}],"units":"Participants"}],"title":"Dyspnoea, week 6"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-5.99","upperLimit":"-1.68","value":"-3.83"},{"groupId":"OG001","lowerLimit":"-7.96","upperLimit":"-3.54","value":"-5.75"},{"groupId":"OG002","lowerLimit":"-9.41","upperLimit":"-1.35","value":"-5.38"},{"groupId":"OG003","lowerLimit":"-11.04","upperLimit":"-2.30","value":"-6.67"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"225"},{"groupId":"OG001","value":"203"},{"groupId":"OG002","value":"61"},{"groupId":"OG003","value":"52"}],"units":"Participants"}],"title":"Dyspnoea, week 12"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-7.18","upperLimit":"-2.76","value":"-4.97"},{"groupId":"OG001","lowerLimit":"-7.46","upperLimit":"-2.95","value":"-5.21"},{"groupId":"OG002","lowerLimit":"-11.54","upperLimit":"-3.79","value":"-7.67"},{"groupId":"OG003","lowerLimit":"-11.66","upperLimit":"-3.30","value":"-7.48"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"214"},{"groupId":"OG001","value":"199"},{"groupId":"OG002","value":"59"},{"groupId":"OG003","value":"52"}],"units":"Participants"}],"title":"Dyspnoea, week 18"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-7.06","upperLimit":"-2.25","value":"-4.65"},{"groupId":"OG001","lowerLimit":"-7.02","upperLimit":"-2.09","value":"-4.56"},{"groupId":"OG002","lowerLimit":"-11.84","upperLimit":"-3.34","value":"-7.59"},{"groupId":"OG003","lowerLimit":"-10.27","upperLimit":"-1.08","value":"-5.67"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"202"},{"groupId":"OG001","value":"185"},{"groupId":"OG002","value":"55"},{"groupId":"OG003","value":"47"}],"units":"Participants"}],"title":"Dyspnoea, week 24"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-6.34","upperLimit":"-1.45","value":"-3.89"},{"groupId":"OG001","lowerLimit":"-6.22","upperLimit":"-1.15","value":"-3.68"},{"groupId":"OG002","lowerLimit":"-10.59","upperLimit":"-1.02","value":"-5.81"},{"groupId":"OG003","lowerLimit":"-8.58","upperLimit":"1.65","value":"-3.46"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"195"},{"groupId":"OG001","value":"172"},{"groupId":"OG002","value":"55"},{"groupId":"OG003","value":"49"}],"units":"Participants"}],"title":"Dyspnoea, week 30"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-5.52","upperLimit":"-0.24","value":"-2.88"},{"groupId":"OG001","lowerLimit":"-4.83","upperLimit":"0.75","value":"-2.04"},{"groupId":"OG002","lowerLimit":"-8.91","upperLimit":"0.48","value":"-4.21"},{"groupId":"OG003","lowerLimit":"-7.28","upperLimit":"2.93","value":"-2.18"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"184"},{"groupId":"OG001","value":"151"},{"groupId":"OG002","value":"52"},{"groupId":"OG003","value":"43"}],"units":"Participants"}],"title":"Dyspnoea, week 36"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-12.77","upperLimit":"-9.17","value":"-10.97"},{"groupId":"OG001","lowerLimit":"-13.47","upperLimit":"-9.84","value":"-11.65"},{"groupId":"OG002","lowerLimit":"-17.17","upperLimit":"-10.33","value":"-13.75"},{"groupId":"OG003","lowerLimit":"-12.19","upperLimit":"-4.79","value":"-8.49"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"248"},{"groupId":"OG001","value":"252"},{"groupId":"OG002","value":"67"},{"groupId":"OG003","value":"57"}],"units":"Participants"}],"title":"Cough, First 9 months"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-9.30","upperLimit":"-4.51","value":"-6.90"},{"groupId":"OG001","lowerLimit":"-7.20","upperLimit":"-2.46","value":"-4.83"},{"groupId":"OG002","lowerLimit":"-9.00","upperLimit":"-0.20","value":"-4.60"},{"groupId":"OG003","lowerLimit":"-8.46","upperLimit":"1.07","value":"-3.69"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"241"},{"groupId":"OG001","value":"246"},{"groupId":"OG002","value":"67"},{"groupId":"OG003","value":"57"}],"units":"Participants"}],"title":"Cough, week 1"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-11.58","upperLimit":"-6.49","value":"-9.04"},{"groupId":"OG001","lowerLimit":"-12.05","upperLimit":"-6.98","value":"-9.52"},{"groupId":"OG002","lowerLimit":"-17.15","upperLimit":"-7.37","value":"-12.26"},{"groupId":"OG003","lowerLimit":"-9.01","upperLimit":"1.54","value":"-3.73"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"236"},{"groupId":"OG001","value":"236"},{"groupId":"OG002","value":"66"},{"groupId":"OG003","value":"57"}],"units":"Participants"}],"title":"Cough, week 2"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-12.37","upperLimit":"-7.20","value":"-9.78"},{"groupId":"OG001","lowerLimit":"-12.82","upperLimit":"-7.65","value":"-10.24"},{"groupId":"OG002","lowerLimit":"-16.66","upperLimit":"-7.24","value":"-11.95"},{"groupId":"OG003","lowerLimit":"-10.57","upperLimit":"-0.54","value":"-5.56"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"239"},{"groupId":"OG001","value":"237"},{"groupId":"OG002","value":"63"},{"groupId":"OG003","value":"57"}],"units":"Participants"}],"title":"Cough, week 3"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-13.87","upperLimit":"-8.63","value":"-11.25"},{"groupId":"OG001","lowerLimit":"-15.96","upperLimit":"-10.76","value":"-13.36"},{"groupId":"OG002","lowerLimit":"-17.80","upperLimit":"-7.77","value":"-12.78"},{"groupId":"OG003","lowerLimit":"-15.75","upperLimit":"-4.90","value":"-10.32"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"206"},{"groupId":"OG001","value":"211"},{"groupId":"OG002","value":"63"},{"groupId":"OG003","value":"53"}],"units":"Participants"}],"title":"Cough, week 4"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-15.64","upperLimit":"-10.31","value":"-12.98"},{"groupId":"OG001","lowerLimit":"-16.21","upperLimit":"-10.88","value":"-13.55"},{"groupId":"OG002","lowerLimit":"-23.11","upperLimit":"-12.38","value":"-17.74"},{"groupId":"OG003","lowerLimit":"-14.84","upperLimit":"-3.55","value":"-9.20"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"199"},{"groupId":"OG001","value":"196"},{"groupId":"OG002","value":"57"},{"groupId":"OG003","value":"55"}],"units":"Participants"}],"title":"Cough, week 5"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-14.56","upperLimit":"-9.19","value":"-11.88"},{"groupId":"OG001","lowerLimit":"-14.63","upperLimit":"-9.21","value":"-11.92"},{"groupId":"OG002","lowerLimit":"-22.36","upperLimit":"-11.48","value":"-16.92"},{"groupId":"OG003","lowerLimit":"-16.52","upperLimit":"-4.64","value":"-10.58"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"222"},{"groupId":"OG001","value":"214"},{"groupId":"OG002","value":"64"},{"groupId":"OG003","value":"53"}],"units":"Participants"}],"title":"Cough, week 6"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-15.95","upperLimit":"-10.78","value":"-13.36"},{"groupId":"OG001","lowerLimit":"-16.24","upperLimit":"-10.90","value":"-13.57"},{"groupId":"OG002","lowerLimit":"-21.39","upperLimit":"-9.64","value":"-15.51"},{"groupId":"OG003","lowerLimit":"-14.41","upperLimit":"-1.67","value":"-8.04"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"225"},{"groupId":"OG001","value":"203"},{"groupId":"OG002","value":"61"},{"groupId":"OG003","value":"52"}],"units":"Participants"}],"title":"Cough, week 12"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-15.25","upperLimit":"-9.37","value":"-12.31"},{"groupId":"OG001","lowerLimit":"-14.03","upperLimit":"-7.98","value":"-11.00"},{"groupId":"OG002","lowerLimit":"-17.19","upperLimit":"-6.40","value":"-11.79"},{"groupId":"OG003","lowerLimit":"-15.23","upperLimit":"-3.65","value":"-9.44"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"214"},{"groupId":"OG001","value":"199"},{"groupId":"OG002","value":"59"},{"groupId":"OG003","value":"52"}],"units":"Participants"}],"title":"Cough, week 18"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-14.24","upperLimit":"-8.43","value":"-11.34"},{"groupId":"OG001","lowerLimit":"-16.17","upperLimit":"-10.14","value":"-13.16"},{"groupId":"OG002","lowerLimit":"-22.84","upperLimit":"-12.39","value":"-17.61"},{"groupId":"OG003","lowerLimit":"-20.56","upperLimit":"-9.29","value":"-14.92"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"202"},{"groupId":"OG001","value":"185"},{"groupId":"OG002","value":"55"},{"groupId":"OG003","value":"47"}],"units":"Participants"}],"title":"Cough, week 24"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-13.21","upperLimit":"-7.46","value":"-10.34"},{"groupId":"OG001","lowerLimit":"-15.44","upperLimit":"-9.41","value":"-12.43"},{"groupId":"OG002","lowerLimit":"-21.46","upperLimit":"-9.45","value":"-15.45"},{"groupId":"OG003","lowerLimit":"-15.75","upperLimit":"-2.94","value":"-9.35"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"195"},{"groupId":"OG001","value":"172"},{"groupId":"OG002","value":"55"},{"groupId":"OG003","value":"49"}],"units":"Participants"}],"title":"Cough, week 30"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-14.48","upperLimit":"-8.49","value":"-11.49"},{"groupId":"OG001","lowerLimit":"-17.85","upperLimit":"-11.39","value":"-14.62"},{"groupId":"OG002","lowerLimit":"-20.65","upperLimit":"-8.58","value":"-14.62"},{"groupId":"OG003","lowerLimit":"-15.14","upperLimit":"-1.96","value":"-8.55"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"184"},{"groupId":"OG001","value":"151"},{"groupId":"OG002","value":"52"},{"groupId":"OG003","value":"43"}],"units":"Participants"}],"title":"Cough, week 36"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-8.24","upperLimit":"-5.01","value":"-6.62"},{"groupId":"OG001","lowerLimit":"-8.04","upperLimit":"-4.78","value":"-6.41"},{"groupId":"OG002","lowerLimit":"-5.84","upperLimit":"0.26","value":"-2.79"},{"groupId":"OG003","lowerLimit":"-8.05","upperLimit":"-1.44","value":"-4.74"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"248"},{"groupId":"OG001","value":"252"},{"groupId":"OG002","value":"67"},{"groupId":"OG003","value":"57"}],"units":"Participants"}],"title":"Pain in Chest, First 9 months"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-4.19","upperLimit":"0.32","value":"-1.93"},{"groupId":"OG001","lowerLimit":"-6.50","upperLimit":"-2.03","value":"-4.26"},{"groupId":"OG002","lowerLimit":"-5.98","upperLimit":"2.40","value":"-1.79"},{"groupId":"OG003","lowerLimit":"-8.71","upperLimit":"0.38","value":"-4.16"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"241"},{"groupId":"OG001","value":"246"},{"groupId":"OG002","value":"67"},{"groupId":"OG003","value":"57"}],"units":"Participants"}],"title":"Pain in Chest, week 1"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-8.13","upperLimit":"-3.74","value":"-5.94"},{"groupId":"OG001","lowerLimit":"-8.51","upperLimit":"-4.13","value":"-6.32"},{"groupId":"OG002","lowerLimit":"-8.63","upperLimit":"-0.89","value":"-4.76"},{"groupId":"OG003","lowerLimit":"-7.18","upperLimit":"1.17","value":"-3.00"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"236"},{"groupId":"OG001","value":"236"},{"groupId":"OG002","value":"66"},{"groupId":"OG003","value":"57"}],"units":"Participants"}],"title":"Pain in Chest, week 2"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-9.31","upperLimit":"-5.04","value":"-7.17"},{"groupId":"OG001","lowerLimit":"-7.49","upperLimit":"-3.23","value":"-5.36"},{"groupId":"OG002","lowerLimit":"-4.90","upperLimit":"3.39","value":"-0.76"},{"groupId":"OG003","lowerLimit":"-9.18","upperLimit":"-0.36","value":"-4.77"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"239"},{"groupId":"OG001","value":"237"},{"groupId":"OG002","value":"63"},{"groupId":"OG003","value":"57"}],"units":"Participants"}],"title":"Pain in Chest, week 3"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-9.60","upperLimit":"-5.29","value":"-7.45"},{"groupId":"OG001","lowerLimit":"-8.54","upperLimit":"-4.26","value":"-6.40"},{"groupId":"OG002","lowerLimit":"-6.32","upperLimit":"2.07","value":"-2.13"},{"groupId":"OG003","lowerLimit":"-8.78","upperLimit":"0.34","value":"-4.22"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"206"},{"groupId":"OG001","value":"211"},{"groupId":"OG002","value":"63"},{"groupId":"OG003","value":"53"}],"units":"Participants"}],"title":"Pain in Chest, week 4"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-9.54","upperLimit":"-5.11","value":"-7.33"},{"groupId":"OG001","lowerLimit":"-9.20","upperLimit":"-4.76","value":"-6.98"},{"groupId":"OG002","lowerLimit":"-4.67","upperLimit":"3.42","value":"-0.62"},{"groupId":"OG003","lowerLimit":"-11.05","upperLimit":"-2.60","value":"-6.82"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"199"},{"groupId":"OG001","value":"196"},{"groupId":"OG002","value":"57"},{"groupId":"OG003","value":"55"}],"units":"Participants"}],"title":"Pain in Chest, week 5"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-7.30","upperLimit":"-2.68","value":"-4.99"},{"groupId":"OG001","lowerLimit":"-9.41","upperLimit":"-4.75","value":"-7.08"},{"groupId":"OG002","lowerLimit":"-3.40","upperLimit":"5.29","value":"0.94"},{"groupId":"OG003","lowerLimit":"-11.00","upperLimit":"-1.52","value":"-6.26"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"222"},{"groupId":"OG001","value":"214"},{"groupId":"OG002","value":"64"},{"groupId":"OG003","value":"53"}],"units":"Participants"}],"title":"Pain in Chest, week 6"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-9.56","upperLimit":"-5.01","value":"-7.28"},{"groupId":"OG001","lowerLimit":"-9.05","upperLimit":"-4.35","value":"-6.70"},{"groupId":"OG002","lowerLimit":"-8.77","upperLimit":"1.35","value":"-3.71"},{"groupId":"OG003","lowerLimit":"-10.62","upperLimit":"0.36","value":"-5.13"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"225"},{"groupId":"OG001","value":"203"},{"groupId":"OG002","value":"61"},{"groupId":"OG003","value":"52"}],"units":"Participants"}],"title":"Pain in Chest, week 12"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-9.22","upperLimit":"-4.36","value":"-6.79"},{"groupId":"OG001","lowerLimit":"-10.40","upperLimit":"-5.41","value":"-7.90"},{"groupId":"OG002","lowerLimit":"-9.05","upperLimit":"0.26","value":"-4.40"},{"groupId":"OG003","lowerLimit":"-12.23","upperLimit":"-2.25","value":"-7.24"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"214"},{"groupId":"OG001","value":"199"},{"groupId":"OG002","value":"59"},{"groupId":"OG003","value":"52"}],"units":"Participants"}],"title":"Pain in Chest, week 18"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-10.26","upperLimit":"-5.18","value":"-7.72"},{"groupId":"OG001","lowerLimit":"-9.95","upperLimit":"-4.72","value":"-7.34"},{"groupId":"OG002","lowerLimit":"-10.48","upperLimit":"-0.84","value":"-5.66"},{"groupId":"OG003","lowerLimit":"-8.36","upperLimit":"2.07","value":"-3.15"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"202"},{"groupId":"OG001","value":"185"},{"groupId":"OG002","value":"55"},{"groupId":"OG003","value":"47"}],"units":"Participants"}],"title":"Pain in Chest, week 24"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-10.80","upperLimit":"-5.87","value":"-8.33"},{"groupId":"OG001","lowerLimit":"-9.18","upperLimit":"-4.02","value":"-6.60"},{"groupId":"OG002","lowerLimit":"-9.62","upperLimit":"1.12","value":"-4.25"},{"groupId":"OG003","lowerLimit":"-9.76","upperLimit":"1.72","value":"-4.02"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"195"},{"groupId":"OG001","value":"172"},{"groupId":"OG002","value":"55"},{"groupId":"OG003","value":"49"}],"units":"Participants"}],"title":"Pain in Chest, week 30"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-10.59","upperLimit":"-5.30","value":"-7.94"},{"groupId":"OG001","lowerLimit":"-8.43","upperLimit":"-2.73","value":"-5.58"},{"groupId":"OG002","lowerLimit":"-9.42","upperLimit":"2.30","value":"-3.56"},{"groupId":"OG003","lowerLimit":"-9.80","upperLimit":"3.00","value":"-3.40"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"184"},{"groupId":"OG001","value":"151"},{"groupId":"OG002","value":"52"},{"groupId":"OG003","value":"43"}],"units":"Participants"}],"title":"Pain in Chest, week 36"}],"denoms":[{"counts":[{"groupId":"OG000","value":"279"},{"groupId":"OG001","value":"277"},{"groupId":"OG002","value":"71"},{"groupId":"OG003","value":"65"}],"units":"Participants"}],"description":"The EORTC QLQ-LC13 was a lung-cancer-specific module comprising 13 questions to assess lung cancer symptoms (cough, haemoptysis, dyspnoea, and site-specific pain); treatment related side-effects (sore mouth, dysphagia, peripheral neuropathy, and alopecia); and pain medication. An outcome variable consisting of a score from 0 to 100 was derived for each of the symptom scales/symptom items. Higher scores on the global health status/QoL and functioning scales indicated better health status/QoL and function. Higher scores on the symptoms scales indicated greater symptom burden. The analysis was performed using a Mixed-effects model for repeated measures analysis on the change from baseline in PRO symptom score at each visit up to 9 months (281 days), including participants, treatment, visit and treatment by visit interaction as explanatory variables, the baseline PRO score as a covariate along with the baseline PRO score by visit interaction, using an unstructured covariance structure.","dispersionType":"95% Confidence Interval","groups":[{"description":"Randomized participants received Osimertinib 80 mg orally once daily (QD)","id":"OG000","title":"Osimertinib 80 mg (Global Cohort)"},{"description":"Randomized participant received Standard of care (SoC) Epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI). Participants received gefitinib 250 mg orally QD or erlotinib 150 mg orally QD.","id":"OG001","title":"SoC EGFR-TKI (Global Cohort)"},{"description":"Randomized participants received Osimertinib 80 mg orally once daily (QD)","id":"OG002","title":"Osimertinib 80 mg (China Cohort)"},{"description":"Randomized participant received Standard of care (SoC) Epidermal growth factor receptor-tyrosine kinase inhibitor (EGFRTKI). Participants received gefitinib 250 mg orally QD or erlotinib 150 mg orally QD.","id":"OG003","title":"SoC EGFR-TKI (China Cohort)"}],"paramType":"LEAST_SQUARES_MEAN","populationDescription":"The full analysis set (FAS) and China-only FAS. FAS included all randomized participants prior to the end of global recruitment. The China-only FAS included all China participants randomized in mainland-China as part of the global study and all additional China participants recruited in mainland China after global recruitment was completed.","reportingStatus":"POSTED","timeFrame":"Questionnaires completed at baseline, first 9 months, and at week 1, 2, 3, 4, 5, 6, 12, 18, 24, 30 and 36","title":"Change From Baseline in European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life (QLQ) Questionnaires Lung Cancer 13 (QLQ-LC13)","type":"SECONDARY","unitOfMeasure":"Unit on scale"}