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Eligible participants who received enzalutamide during double blind and who provided consent to take part in open-label period continued to receive 160 mg of enzalutamide in open-label period orally once a day until PSA progression and radiographic disease progression were centrally confirmed and 1 of the following 2 events became applicable to the participants: (1) initiation of cytotoxic chemotherapy or (2) initiation of an investigational agent for treatment of prostate cancer (up to 54.3 months).","id":"OG000","title":"Enzalutamide"},{"description":"Inactive metabolite.","id":"OG001","title":"M1- Carboxylic Acid Metabolite"},{"description":"N-desmethyl enzalutamide (active metabolite).","id":"OG002","title":"M2- N-Desmethyl Enzalutamide"},{"description":"Active metabolite.","id":"OG003","title":"Enzalutamide Plus M2"}],"paramType":"MEAN","populationDescription":"The Pharmacokinetic Analysis Set (PKAS) population consisted of all participants who received at least 1 dose of study drug and who provided blood samples for drug concentrations at least 1 time point.","reportingStatus":"POSTED","timeFrame":"From the date of randomization up to Days 2, 3, 8, 22, 29, 43, 57, 85, 86, 113, 141 and 169","title":"Observed Plasma Concentration in Predose Samples Obtained During Multiple-dose Administration of Minimum Concentration (Plasma Concentration at Pre Dose) (Cmin) Enzalutamide, M1,M2 and Enzalutamide Plus M2","type":"SECONDARY","unitOfMeasure":"μg/mL"}