{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"230","value":"692"},{"groupId":"OG001","spread":"211","value":"703"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"18"},{"groupId":"OG001","value":"19"}],"units":"Participants"}],"title":"acMMAE: Cycle 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"165","value":"845"},{"groupId":"OG001","spread":"70.6","value":"713"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"17"},{"groupId":"OG001","value":"12"}],"units":"Participants"}],"title":"acMMAE: Cycle 4"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"8.04","value":"33.3"},{"groupId":"OG001","spread":"7.63","value":"39.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"18"},{"groupId":"OG001","value":"19"}],"units":"Participants"}],"title":"Total Ab: Cycle 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"11.2","value":"56.1"},{"groupId":"OG001","spread":"4.51","value":"37.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"17"},{"groupId":"OG001","value":"12"}],"units":"Participants"}],"title":"Total Ab: Cycle 4"},{"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"}],"units":"Participants"}],"title":"Unconjugated MMAE: Cycle 1"},{"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"}],"units":"Participants"}],"title":"Unconjugated MMAE: Cycle 4"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"1.58","value":"3.30"},{"groupId":"OG001","spread":"4.30","value":"5.47"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"16"},{"groupId":"OG001","value":"19"}],"units":"Participants"}],"title":"Bendamustine: Cycle 1"},{"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"}],"units":"Participants"}],"title":"Bendamustine: Cycle 4"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"72.8","value":"349"},{"groupId":"OG001","spread":"118","value":"274"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"14"},{"groupId":"OG001","value":"13"}],"units":"Participants"}],"title":"Obinutuzumab: Cycle 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"217","value":"727"},{"groupId":"OG001","spread":"190","value":"666"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"16"},{"groupId":"OG001","value":"12"}],"units":"Participants"}],"title":"Obinutuzumab: Cycle 4"}],"denoms":[{"counts":[{"groupId":"OG000","value":"18"},{"groupId":"OG001","value":"19"}],"units":"Participants"}],"description":"PK of three pola-related analytes: acMMAE, unconjugated MMAE and total antibody were measured.","dispersionType":"Standard Deviation","groups":[{"description":"Participants with FL received pola, 1.8 mg/kg, as IV infusion on Day 2 of Cycle 1 (each cycle is 28 days), and thereafter on Day 1 of Cycles 2 to 6. Participants also received bendamustine 90 mg/m\\^2, as IV infusion on Days 2 and 3 of Cycle 1, and thereafter on Days 1 and 2 of Cycles 2 to 6 and obinutuzumab 1000 mg, as IV infusion on Days 1, 8, and 15 of Cycle 1 and on Day 1 of Cycles 2 to 6 in combination with pola.","id":"OG000","title":"Arm E (Phase II Expansion): Pola+BG in FL"},{"description":"Participants with DLBCL received pola, 1.8 mg/kg, as IV infusion on Day 2 of Cycle 1 (each cycle is 21 days), and thereafter on Day 1 of Cycles 2 to 6. Participants also received bendamustine 90 mg/m\\^2, as IV infusion on Days 2 and 3 of Cycle 1, and thereafter on Days 1 and 2 of Cycles 2 to 6 and obinutuzumab 1000 mg, as IV infusion on Days 1, 8, and 15 of Cycle 1 and on Day 1 of Cycles 2 to 6 in combination with pola.","id":"OG001","title":"Arm F (Phase II Expansion): Pola+BG in DLBCL"}],"paramType":"MEAN","populationDescription":"PK evaluable population included all the ITT participants in Arms E and F who received at least one study treatment and who provided suitable PK samples. 'Overall Number Analyzed' are the number of participants with data available for analysis. 'Number Analyzed' is the number of participants with data available for analysis at a specified timepoints.","reportingStatus":"POSTED","timeFrame":"Cycle 1; Cycle 4 (cycle length is 21 days for DLBCL cohorts and 28 days for FL cohorts)","title":"Phase II: Cmax of Polatuzumab Vedotin, Obinutuzumab and Bendamustine in Arms E and F","type":"SECONDARY","unitOfMeasure":"ug/mL"}