{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"75"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"19"}],"units":"Participants"}],"description":"Rolling-6 design was used to estimate MTD. The MTD was empirically defined as the highest dose level at which six patients were treated with at most one patient experiencing a dose-limiting toxicity (DLT) and the next higher dose level had been determined to be too toxic. Stratum I consisted of less-heavily pre-treated patients.","groups":[{"description":"Of 21 patients enrolled on stratum I, 2 patients were not evaluable for dose finding assessment due to receiving less than required dose of study drug. The remaining 19 patients were used to determine the MTD for stratum I.","id":"OG000","title":"Stratum I"}],"paramType":"NUMBER","populationDescription":"Patients who were enrolled on stratum I and were evaluable for dose finding assessment were used to determine the MTD for stratum I.","reportingStatus":"POSTED","timeFrame":"4 weeks","title":"Maximum Tolerated Dose (MTD) of Palbociclib in Stratum I","type":"PRIMARY","unitOfMeasure":"mg/m2/day"}